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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Positive-Pressure Respiration, Intrinsic Clear all
Completed Not applicable Interventional Results available

Titration Pressures in Sleep Apnea Patients Using ThermoSmart® Versus Conventional Humidification

NCT00681083
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Heated breathing tube (CPAP with ThermoSmart), Non heated breathing tube (CPAP with conventional humidification)
Device
Lead sponsor
Fisher and Paykel Healthcare
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
2
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 11, 2019 · Synced Jul 24, 2026, 7:57 AM EDT
Not listed Not applicable Interventional

Peer-Driven Intervention for Sleep Apnea

NCT02056002
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Usual Care, Peer-Buddy System
Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 85 Years
Enrollment
362 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 4, 2017 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional Results available

Positive Airway Pressure Program

NCT02331992
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Adherence program
Behavioral
Lead sponsor
Fisher and Paykel Healthcare
Industry
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
3
States / cities
Huntsville, Alabama • Belleville, Illinois • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 28, 2018 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional

Postoperative Nasal High Flow Versus Oxygen for Positive Airway Pressure Non-Compliance Sleep Apnea Patients

NCT02485236
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Low flow oxygen via nasal cannula, Humidified Nasal High Flow Therapy
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional Results available

Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea

NCT01196117
View directory record Official record
Conditions
Sleep Apnea, Sleep Disordered Breathing
Interventions
14 days of placebo therapy, 14 days of CPAP therapy
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 90 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 31, 2020 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

User Preference/Validation Evaluation of the New Philips Respironics Positive Airway Pressure Application

NCT03748264
View directory record Official record
Conditions
Sleep Disordered Breathing
Interventions
Standard of Care, DreamMapper Application, DreamMapper Application with Therapist Assist
Other · Device
Lead sponsor
Philips Respironics
Industry
Eligibility
21 Years to 75 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
5
States / cities
Little Rock, Arkansas • Atlanta, Georgia • Indianapolis, Indiana + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2021 · Synced Jul 24, 2026, 7:57 AM EDT
Completed No phase listed Observational

Correlation Between CPAP Compliance and Food Intake Timing

NCT01851811
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Not listed
Lead sponsor
Hackensack Meridian Health
Other
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Hackensack, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 3, 2014 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Targeted CPAP Therapy for Obstructive Sleep Apnea in Pregnancy

NCT02755831
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
CPAP, Pre-natal care
Device · Other
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years and older · Female only
Enrollment
193 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 26, 2019 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional

Use of a 3D Printer to Make Custom Sleep Masks for Positive Airway Pressure Treatment

NCT02896751
View directory record Official record
Conditions
Sleep Apnea, Pediatric Sleep Apnea
Interventions
3D printed NIV mask
Device
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
5 Years to 25 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Jul 24, 2026, 7:57 AM EDT
Recruiting Not applicable Interventional

NPA-OSA Device Tolerability, Usability and Acclimation Clinical Study in Adult Obstructive Sleep Apnea (OSA) Patients

NCT06677151
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
nasopharyngeal airway obstructive sleep apnea (NPA-OSA) device
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional

Impact of Automated Education and Follow-up Mechanisms on Patient Engagement

NCT02279901
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Telemedicine Education, IVR
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
1,873 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Fontana, California
Source: ClinicalTrials.gov public record
Updated Mar 5, 2017 · Synced Jul 24, 2026, 7:57 AM EDT
Recruiting Phase 3 Interventional

AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

NCT07571109
View directory record Official record
Conditions
Obesity, Overweight, Obstructive Sleep Apnoea
Interventions
NNC0487-0111, Placebo (matched to NNC0487-0111)
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
20
States / cities
Gilbert, Arizona • Bradenton, Florida • Naples, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional Results available

Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment

NCT00252629
View directory record Official record
Conditions
Apnea, Sleep, Chronic Fatigue Syndrome
Interventions
Nasal CPAP treatment during sleep
Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
32 Years to 52 Years · Male only
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Northport, New York
Source: ClinicalTrials.gov public record
Updated Dec 10, 2014 · Synced Jul 24, 2026, 7:57 AM EDT
Terminated Not applicable Interventional

Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure

NCT02680704
View directory record Official record
Conditions
Intracranial Hypertension, Critical Illness, Brain Injuries, Lung Injury, Respiratory Failure, Positive-Pressure Respiration, Intrinsic
Interventions
PEEP titrated mechanical ventilation
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 21, 2019 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional

Study of Provent Treatment of Obstructive Sleep Apnea in Patients Who Are Non-compliant With CPAP

NCT00901771
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Provent
Device
Lead sponsor
St. Luke's Hospital, Chesterfield, Missouri
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 14, 2010 · Synced Jul 24, 2026, 7:57 AM EDT
Recruiting Phase 1 Interventional

Benefits of Oxytocin in Obstructive Sleep Apnea (OSA) Patients Using Continuous Positive Airway Pressure (CPAP) Machine

NCT03860233
View directory record Official record
Conditions
Sleep Apnea, Sleep Apnea, Obstructive
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
Vivek Jain
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Phase 2 Interventional

Weekly Phone Calls Versus Brief Patient Education to Improve Continuous Positive Airway Pressure (CPAP) Compliance

NCT00945776
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
Weekly phone calls, Frequently asked questions, Usual care
Behavioral
Lead sponsor
CAMC Health System
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 23, 2009 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional Results available

Study of Positive Airway Pressure in Preeclampsia to Reduce Blood Pressure

NCT01029691
View directory record Official record
Conditions
Preeclampsia, Hypertension
Interventions
Positive Airway Pressure
Device
Lead sponsor
University of Michigan
Other
Eligibility
14 Years and older · Female only
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 15, 2017 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional Results available

Self-Management of Continuous Positive Airway Pressure Settings

NCT03536572
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Sleep Apnea Self-Management Program
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional Results available

Feasibility of Improving Sleep Apnea Treatment Adherence After Brain Injury

NCT04221009
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Brain Injuries, Traumatic
Interventions
MI and CBT 4-session manualized intervention
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 7, 2024 · Synced Jul 24, 2026, 7:57 AM EDT
Terminated Not applicable Interventional Results available

Assessment of Continuous Positive Airway Pressure Therapy in OSA and ILD

NCT03901534
View directory record Official record
Conditions
Interstitial Lung Disease, Obstructive Sleep Apnea
Interventions
Continuous positive airway pressure (CPAP) therapy, Nox A1 Recorder
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
2,021 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
2
States / cities
Boston, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 19, 2024 · Synced Jul 24, 2026, 7:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pilot Study of the Comparison of the Upper Airway Dynamics of Oronasal vs Nasal Masks With PAP Treatment

NCT01939938
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
Nasal and Oronasal PAP Mask
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 16, 2018 · Synced Jul 24, 2026, 7:57 AM EDT
Not yet recruiting Not applicable Interventional

Enhancing PAP Adherence Among Spanish-speaking Hispanic Adults With OSA

NCT05618444
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Automated Management (AM)
Behavioral
Lead sponsor
Geisinger Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
4
States / cities
Fontana, California • Kansas City, Kansas • Danville, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Jul 24, 2026, 7:57 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Mechanisms for Individual Differences in Hypertension in Obstructive Sleep

NCT03176732
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Hypertension
Interventions
Positive Airway Pressure
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 75 Years
Enrollment
155 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Jul 24, 2026, 7:57 AM EDT