Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 13, 2026, 7:05 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 714 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Post-operation Pain Clear all

Conditions: Postoperative Pain, Hysterectomy
Interventions: IV Acetaminophen, IV Placebo 100 mL solution; Drug
Lead sponsor: Mallinckrodt; Industry
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 331 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 27
States / cities: Birmingham, Alabama • Sheffield, Alabama • Phoenix, Arizona + 21 more

Conditions: Arthritis - Post Surgical, Other Activity-limiting Pain
Interventions: Cognitive-Behavioral Pain Self-management Program; Behavioral
Lead sponsor: Visiting Nurse Service of New York; Other
Eligibility: 55 Years and older
Enrollment: 658 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: New York, New York

Conditions: Oral Surgery
Interventions: Vicodin, Dexamethasone; Drug
Lead sponsor: Boston University; Other
Eligibility: 21 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Postoperative Pain, Opioid Use, Prolapse; Female, Incontinence
Interventions: Standard opioid prescribing, Restrictive opioid prescribing; Other
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older · Female only
Enrollment: 129 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: ACL Surgery, Pain Management
Interventions: Meloxicam 15 mg, Medrol 4 MG Oral Tablet Includes Medrol Dosepak, Gabapentin 300 mg, Hydrocodone 5Mg/Acetaminophen 325Mg Tab, Ketorolac 10 Mg Oral Tablet; Drug
Lead sponsor: St. Louis University; Other
Eligibility: 13 Years to 50 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2031
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Pulmonary Dysfunction, Median Sternotomy Recovery, Postoperative Pain
Interventions: Intercostal Nerve Cryoablation; Device
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 40 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Cesarean Section Complications, Pain, Opioid Use
Interventions: Liposomal bupivacaine, Bupivacaine Hydrochloride, saline; Drug · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older · Female only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Cataract
Interventions: Nepafenac Ophthalmic Suspension, 0.3%, Nepafenac Ophthalmic Suspension, 0.1%, Nepafenac Ophthalmic Suspension 0.3% Vehicle, NEVANAC Vehicle; Drug · Other
Lead sponsor: Alcon Research; Industry
Eligibility: 18 Years and older
Enrollment: 2,120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2010
U.S. locations: 1
States / cities: Fort Worth, Texas

Conditions: Acute Pain
Interventions: Oxymorphone immediate release; Drug
Lead sponsor: Endo USA Inc., a Keenova Therapeutics Company; Industry
Eligibility: 18 Years and older
Enrollment: 320 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2005
U.S. locations: 21
States / cities: Birmingham, Alabama • Montgomery, Alabama • Phoenix, Arizona + 10 more

Conditions: Post-operation Pain
Interventions: MDT-10013; Drug
Lead sponsor: Medtronic Spinal and Biologics; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016
U.S. locations: 3
States / cities: Birmingham, Alabama • DeLand, Florida • Altoona, Pennsylvania

Conditions: Postoperative Pain
Interventions: Acetaminophen Oral Tablet, placebo oral tablet, Acetaminophen infusion, Placebo infusion; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Stanford, California

Conditions: Pain
Interventions: Skin conductance monitor for measuring skin conductance; Device
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: Up to 5 Years
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Post Operative Pain
Interventions: SABER-Bupivacaine (Part 1), SABER-Bupivacaine (Part 2), Saline Placebo, Bupivacaine HCl; Drug
Lead sponsor: Durect; Industry
Eligibility: 18 Years and older
Enrollment: 399 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 21
States / cities: Florence, Alabama • Sheffield, Alabama • Arcadia, California + 13 more

Conditions: Pain, Postoperative Depression
Interventions: Ketamine, Placebo Comparator; Drug · Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Interventions: Cold and Compression, SOC (Standard of care); Device · Other
Lead sponsor: Ochsner Health System; Other
Eligibility: 50 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Postoperative Pain, Total Knee Replacement, Total Knee Arthroplasty, Partial Knee Replacement
Interventions: SPRINT Peripheral Nerve Stimulation (PNS) System; Device
Lead sponsor: SPR Therapeutics, Inc.; Industry
Eligibility: 21 Years and older
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 10
States / cities: Little Rock, Arkansas • San Diego, California • Gainesville, Florida + 7 more

Conditions: Post Operative Pain
Interventions: AtriCure Cryo Nerve Block (cryoNB) Device Family; Device
Lead sponsor: AtriCure, Inc.; Industry
Eligibility: 12 Years and older
Enrollment: 5,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2040
U.S. locations: 7
States / cities: Jacksonville, Florida • Orlando, Florida • Annapolis, Maryland + 4 more

Conditions: Failed Back Surgery Syndrome, Post-Laminectomy Syndrome, Low Back Pain
Interventions: SCS and PNfS, SCS Alone; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 22 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 28
States / cities: Phoenix, Arizona • Scottsdale, Arizona • Little Rock, Arkansas + 24 more

Conditions: Pain, Postoperative
Interventions: diclofenac potassium (XP21L), Placebo; Drug
Lead sponsor: Xanodyne Pharmaceuticals; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2006
U.S. locations: 4
States / cities: Austin, Texas • Houston, Texas • San Marcos, Texas + 1 more

Conditions: Pain, Postoperative, Ankle Fracture Surgery, Opioid Use Disorder, Opioid Dependence, Opioid Analgesia
Interventions: Buprenorphine Transdermal System, Placebo Patch; Drug
Lead sponsor: Jenna-Leigh Wilson; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Pain, Postoperative, Morbid Obesity
Interventions: Injected bupivacaine post-operatively, Streamed bupivacaine versus streamed normal saline, Aerosolized bupivacaine versus aerosolized saline, Injected lidocaine pre-incision vs saline pre-incision; Drug
Lead sponsor: Pinnacle Health System; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Harrisburg, Pennsylvania

Conditions: Knee Replacement, Arthropathy of Knee
Interventions: Dronabinol 5mg Cap, Non-active comparator; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 21 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Carpal Tunnel Surgery, Trigger Finger Disorder, De Quervain Syndrome, Guyon's Canal, Dupuytren Contracture, Morton Neuroma, Tarsal Tunnel Syndrome, Plantar Fasciopathy, Peroneal Nerve Entrapment
Interventions: NAC, NAC 0mg/day (Placebo); Drug
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 75 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Postoperative Ileus, Colon Cancer, Pain, Postoperative, Postoperative Nausea and Vomiting
Interventions: Acupuncture, Sham Acupuncture; Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: New York, New York

Search by objective public record fields.

Efficacy and Safety of Intravenous Acetaminophen Over 48 Hrs for the Treatment of Post-op Pain After Gynecologic Surgery

Treating Pain to Reduce Disability Among Older Home Health Patients

Pilot Study: Effect of Dexamethasone vs Vicodin in Reducing Post-operative Pain

STandard Versus No Opioid Prescription After Prolapse and Anti-INcontinence Surgery Trial

Efficacy of Methylprednisolone for Pain Control After ACL Repair

FROST-STERN Trial: A Trial of Intraoperative Cryoablation for Post Operative Pain Management After Full Sternotomy

Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control

Confirmatory Study Nepafenac 0.3%

Efficacy and Safety of Oxymorphone Immediate Release in Post-surgical Acute Pain

A Feasibility Dose-escalating Study of MDT-10013 for Acute Postoperative Pain Following Total Knee Arthroplasty

Oral Versus Intravenous Acetaminophen in Lumbar Spine Surgery

Post-surgical Pain Assessment in Children: Roles of Skin Conductance and Genomics

Trial of Extended Release Bupivacaine for Pain Relief After Surgery

Study on the Use of Low Dose Ketamine After Gastric Bypass and Gastrectomy

Cold and Compression Post TKA

Treatment of Post-Operative Pain Following Orthopedic Surgery With SPRINT® Peripheral Nerve Stimulation (PNS) System

A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves

SENSE (Subcutaneous and Epidural Neuromodulation System Evaluation) Study

Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery

Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic

Investigating the Effect of Dronabinol on Post-surgical Pain

NAC-REPAIR for Post-surgical Pain

Trial of Acupuncture for Reduction of Post-Colectomy Ileus