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ClinicalTrials.gov public records Last synced Oct 23, 2026, 2:44 AM EDT

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Showing 25–48 of 138 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Presbyopia Condition Clear all
Withdrawn Not applicable Interventional

Evaluation of AcrySof IQ Vivity Extended Vision Intraocular Lenses

NCT06541795
View directory record Official record
Conditions
Aphakia, Presbyopia, Residual Refractive Cylinder
Interventions
AcrySof IQ Vivity Extended Vision IOL
Device
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of a Manufacturing Process for a Frequent Replacement Silicone Hydrogel Multifocal Contact Lens

NCT05765227
View directory record Official record
Conditions
Refractive Ametropia
Interventions
Lehfilcon A multifocal contact lenses, Lotrafilcon B multifocal contact lenses, Hydrogen peroxide-based cleaning and disinfection system
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2024 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Safety and Efficacy Study of BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia

NCT05135286
View directory record Official record
Conditions
Presbyopia
Interventions
BRIMOCHOL™ PF, Carbachol PF, Vehicle
Drug
Lead sponsor
Visus Therapeutics
Other
Eligibility
45 Years to 80 Years
Enrollment
629 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
42
States / cities
Chandler, Arizona • Phoenix, Arizona • Sun City, Arizona + 39 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Continuation Study To Monitor The Long Term Safety Of Patients Completing Protocols ACU-P08-020/020A

NCT01895088
View directory record Official record
Conditions
Presbyopia
Interventions
AcuFocus Corneal Inlay ACI 7000 PDT
Device
Lead sponsor
AcuFocus, Inc.
Industry
Eligibility
45 Years to 60 Years
Enrollment
271 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
13
States / cities
Fayetteville, Arkansas • Los Angeles, California • Newport Beach, California + 10 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2017 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Safety and Efficacy Study of BRIMOCHOL™, BRIMOCHOL™ F, and Carbachol in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia

NCT04774237
View directory record Official record
Conditions
Presbyopia
Interventions
BRIMOCHOL™, BRIMOCHOL™ F, Carbachol
Drug
Lead sponsor
Visus Therapeutics
Other
Eligibility
45 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
3
States / cities
Glendale, California • Newport Beach, California • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 23, 2026, 2:44 AM EDT
Recruiting Not applicable Interventional

Performance of Two Daily Disposable Multifocal Contact Lenses

NCT07444658
View directory record Official record
Conditions
Presbyopia
Interventions
Lens A (kalfilcon A), Lens B (stenfilcon A)
Device
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Trial of the PresVIEW Implant for the Improvement of Near Vision in Patients With Presbyopia

NCT01166568
View directory record Official record
Conditions
Presbyopia
Interventions
PresVIEW Scleral Implants
Device
Lead sponsor
VisDura, Inc.
Industry
Eligibility
50 Years to 60 Years
Enrollment
337 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2015
U.S. locations
14
States / cities
Beverly Hills, California • San Diego, California • Des Plaines, Illinois + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2018 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Effectiveness Study of the AcuFocus Corneal Inlay ACI 7000PDT in Presbyopes

NCT00819299
View directory record Official record
Conditions
Presbyopia
Interventions
AcuFocus Corneal Inlay ACI 7000PDT
Device
Lead sponsor
AcuFocus, Inc.
Industry
Eligibility
45 Years to 60 Years
Enrollment
359 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
15
States / cities
Fayetteville, Arkansas • Los Angeles, California • Newport Beach, California + 12 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2018 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Dispensing Clinical Trial of Comfilcon A Extended Range Multifocal Lenses

NCT02719353
View directory record Official record
Conditions
Presbyopia
Interventions
comfilcon A Extended Range test lens, comfilcon A control lens
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
50 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 30, 2020 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of a Small Aperture Extended Depth of Focus Intraocular Lens

NCT03633695
View directory record Official record
Conditions
Cataract, Presbyopia
Interventions
IC-8 IOL Group, Control Group
Device
Lead sponsor
AcuFocus, Inc.
Industry
Eligibility
22 Years and older
Enrollment
453 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
21
States / cities
Tucson, Arizona • Bakersfield, California • Laguna Hills, California + 18 more
Source: ClinicalTrials.gov public record
Updated Oct 24, 2022 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Not applicable Interventional Results available

Clareon PanOptix Pro vs. Clareon PanOptix - Study B

NCT06401551
View directory record Official record
Conditions
Aphakia, Presbyopia
Interventions
CPO Pro IOL, CPO IOL, Cataract Surgery
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
8
States / cities
Torrance, California • Bloomfield Hills, Michigan • Kansas City, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Not applicable Interventional Results available

Assessing the Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Contact Lenses

NCT05702541
View directory record Official record
Conditions
Presbyopia
Interventions
Lehfilcon A multifocal contact lenses, Lotrafilcon B multifocal contact lenses, Hydrogen peroxide-based cleaning and disinfection system
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Phase 4 Interventional Results available

A Comparison of Visual Function After Bilateral Implantation of Presbyopia-correcting Intraocular Lenses (IOLs)

NCT01166971
View directory record Official record
Conditions
Cataract
Interventions
ReSTOR +3, Tecnis MF
Device
Lead sponsor
Alcon Research
Industry
Eligibility
21 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
3
States / cities
Panama City, Florida • Charleston, South Carolina • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 24, 2011 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Not applicable Interventional Results available

A Study to Evaluate the Feasibility of a High Add Multi Focal Contact Lens

NCT01518868
View directory record Official record
Conditions
Presbyopia
Interventions
Investigational contact lens, PureVision contact lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Oct 23, 2026, 2:44 AM EDT
Not yet recruiting Not applicable Interventional

Contact Lens Trial Fitting Experience

NCT07600645
View directory record Official record
Conditions
Presbyopia
Interventions
Lens A ( stenfilcon A )
Device
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
40 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
2
States / cities
Bellaire, Texas • Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 23, 2026, 2:44 AM EDT
Completed No phase listed Observational

Comfort and Vision With TOTAL30 Multifocal Lenses

NCT07284966
View directory record Official record
Conditions
Myopia, Presbyopia, Astigmatism
Interventions
TOTAL30 Multifocal
Device
Lead sponsor
Scripps Poway Eyecare and Optometry
Other
Eligibility
40 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 23, 2026, 2:44 AM EDT
Terminated Not applicable Interventional Results available

Multifocal Visual Performance Study

NCT03757039
View directory record Official record
Conditions
Presbyopia
Interventions
Multifocal soft contact lenses, Progressive addition lens spectacles
Device · Other
Lead sponsor
Alcon Research
Industry
Eligibility
38 Years to 58 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Early Phase 1 Interventional

Evaluation of NV701 (Pilocarpine 1.25%) Compared With Vuity (Pilocarpine 1.25%) on Pupil Size in Subjects With Presbyopia

NCT06783686
View directory record Official record
Conditions
Pupil Constriction
Interventions
NV701, Pilocarpine 1.25% Eye drop
Drug
Lead sponsor
Novus Vision LLC
Industry
Eligibility
40 Years to 55 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
2
States / cities
Chandler, Arizona • Glendale, California
Source: ClinicalTrials.gov public record
Updated Sep 5, 2025 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Phase 3 Interventional Results available

A Phase 3 Efficacy Study of Pilocarpine HCl Ophthalmic Solution (AGN-190584) in Participants With Presbyopia

NCT03857542
View directory record Official record
Conditions
Presbyopia
Interventions
Pilocarpine HCl Ophthalmic Solution, Vehicle
Drug · Other
Lead sponsor
Allergan
Industry
Eligibility
40 Years to 55 Years
Enrollment
427 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
35
States / cities
Dothan, Alabama • Prescott, Arizona • Sun City, Arizona + 30 more
Source: ClinicalTrials.gov public record
Updated Dec 29, 2021 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Phase 4 Interventional Results available

Presbyopia-Correcting Intraocular Lenses (IOLs)

NCT00963560
View directory record Official record
Conditions
Cataract
Interventions
ReSTOR +3, Crystalens HD, Crystalens AO
Device
Lead sponsor
Alcon Research
Industry
Eligibility
21 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 9, 2011 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Trial of The VisAbility Micro Insert System for Presbyopic Patients

NCT02374671
View directory record Official record
Conditions
Presbyopia
Interventions
VisAbility Micro Insert
Device
Lead sponsor
VisDura, Inc.
Industry
Eligibility
45 Years to 60 Years
Enrollment
365 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
14
States / cities
Orange, California • San Diego, California • Honolulu, Hawaii + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2020 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Single-Center, Double-Masked Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia

NCT03201562
View directory record Official record
Conditions
Presbyopia
Interventions
Aceclidine+tropicamide combination, Aceclidine, Vehicle
Drug
Lead sponsor
LENZ Therapeutics, Inc
Other
Eligibility
48 Years to 64 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Andover, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 22, 2022 · Synced Oct 23, 2026, 2:44 AM EDT
Completed Not applicable Interventional Results available

Clinical Validation Study of Comfilcon A Multifocal Toric Contact Lenses

NCT03417557
View directory record Official record
Conditions
Presbyopia
Interventions
Comfilcon A lens (test), Omafilcon B lens (control)
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
40 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated May 4, 2020 · Synced Oct 23, 2026, 2:44 AM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Pilocarpine and Brimonidine in Patients With Monofocal Lenses

NCT03825081
View directory record Official record
Conditions
Presbyopia, Pseudophakia
Interventions
Brimonidine, pilocarpine
Drug
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
60 Years and older
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 31, 2019 · Synced Oct 23, 2026, 2:44 AM EDT