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ClinicalTrials.gov public records Last synced Sep 4, 2026, 1:04 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Presbyopia
Interventions
Raindrop Near Vision Inlay
Device
Lead sponsor
Eye Center of North Florida
Other
Eligibility
41 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Panama City, Florida
Conditions
Presbyopia
Interventions
BRIMOCHOL™ PF, Carbachol PF, Brimonidine tartrate
Drug
Lead sponsor
Visus Therapeutics
Other
Eligibility
45 Years to 80 Years
Enrollment
182 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
15
States / cities
Glendale, California • Rancho Cordova, California • Jacksonville, Florida + 10 more
Completed No phase listed Observational Accepts healthy volunteers

Post-approval Follow-up Study of the IC-8 Apthera Intraocular Lens (IOL)

NCT05758883
Conditions
Cataract, Presbyopia
Interventions
Not listed
Lead sponsor
AcuFocus, Inc.
Industry
Eligibility
22 Years and older
Enrollment
196 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
20
States / cities
Tucson, Arizona • Bakersfield, California • Laguna Hills, California + 17 more
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Soft Multifocal Lenses in Presbyopic Previous Contact Lens Wearers

NCT06053463
Conditions
Presbyopia
Interventions
Daily disposable multifocal soft contact lens
Device
Lead sponsor
Jennifer Fogt
Other
Eligibility
38 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
2
States / cities
Columbus, Ohio • Granville, Ohio
Conditions
Presbyopia
Interventions
AGN-199201, AGN-190584, AGN-199201 Vehicle
Drug
Lead sponsor
Allergan
Industry
Eligibility
40 Years to 55 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Newport Beach, California
Completed Not applicable Interventional Accepts healthy volunteers Results available

Extended Depth of Focus Contact Lenses for Presbyopia

NCT05495971
Conditions
Presbyopia
Interventions
NaturalVue Multifocal
Device
Lead sponsor
Visioneering Technologies, Inc
Industry
Eligibility
45 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Alpharetta, Georgia
Conditions
Presbyopia
Interventions
There is not an intervention
Diagnostic Test
Lead sponsor
Vance Thompson Vision
Other
Eligibility
37 Years to 48 Years
Enrollment
45 participants
Timeline
2019 – 2020
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Conditions
Contact Lens Comfort and Successful Refitting, Presbyopia
Interventions
DAILIES TOTAL1 Multifocal (delefilcon A)
Device
Lead sponsor
Gordon Schanzlin New Vision
Other
Eligibility
40 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
La Jolla, California
Conditions
Presbyopia
Interventions
AcuFocus Corneal Inlay ACI 7000PDT
Device
Lead sponsor
AcuFocus, Inc.
Industry
Eligibility
45 Years to 60 Years
Enrollment
359 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
15
States / cities
Fayetteville, Arkansas • Los Angeles, California • Newport Beach, California + 12 more
Conditions
Presbyopia, Refractive Errors, Eye Diseases
Interventions
Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle Proprietary Ophthalmic Solution
Drug
Lead sponsor
LENZ Therapeutics, Inc
Other
Eligibility
45 Years to 75 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
5
States / cities
Glendale, California • Indianapolis, Indiana • Andover, Massachusetts + 2 more
Conditions
Glaucoma, Cataract, Presbyopia
Interventions
Cataract Surgery with Implantation of Vivity Extended Range of Vision IOL
Procedure
Lead sponsor
Vance Thompson Vision
Other
Eligibility
45 Years and older
Enrollment
27 participants
Timeline
2021 – 2022
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Phase 3 Efficacy Study of LNZ100 & LNZ101 for the Treatment of Presbyopia

NCT05728944
Conditions
Presbyopia, Near Vision, Refractive Error, Eye Diseases
Interventions
Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle
Drug
Lead sponsor
LENZ Therapeutics, Inc
Other
Eligibility
45 Years to 75 Years
Enrollment
229 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
17
States / cities
Dothan, Alabama • Scottsdale, Arizona • Glendale, California + 14 more
Conditions
Presbyopia
Interventions
Lens A (kalfilcon A), Lens B (stenfilcon A)
Device
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Berkeley, California
Conditions
Aphakia, Presbyopia
Interventions
Clareon PanOptix Pro/Pro Toric Trifocal IOL, Phacoemulsification
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
5
States / cities
Torrance, California • Kansas City, Missouri • Mt. Pleasant, South Carolina + 2 more
Conditions
Presbyopia
Interventions
Aceclidine+tropicamide combination, Aceclidine, Vehicle
Drug
Lead sponsor
LENZ Therapeutics, Inc
Other
Eligibility
48 Years to 64 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Andover, Massachusetts
Completed Not applicable Interventional Accepts healthy volunteers

Apioc Presbyopic Contact Lens

NCT04437732
Conditions
Presbyopia, Refractive Errors
Interventions
Apioc-P and Apioc-PT Contact Lens Design
Device
Lead sponsor
Lentechs, LLC
Industry
Eligibility
40 Years to 70 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Athens, Ohio • Powell, Ohio
Conditions
Presbyopia
Interventions
CSF-1, Vehicle
Drug
Lead sponsor
Orasis Pharmaceuticals Ltd.
Industry
Eligibility
45 Years to 64 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
18
States / cities
Chandler, Arizona • Mesa, Arizona • Phoenix, Arizona + 15 more
Conditions
Presbyopia
Interventions
Phentolamine Opthalmic Solution 0.75%, Placebo, Low dose pilocarpine, Low dose pilocarpine vehicle
Drug · Other
Lead sponsor
Ocuphire Pharma, Inc.
Industry
Eligibility
40 Years to 64 Years
Enrollment
333 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
26
States / cities
Phoenix, Arizona • Azusa, California • Newport Beach, California + 23 more
Completed Phase 4 Interventional Results available

Presbyopia-Correcting Intraocular Lenses (IOLs)

NCT00963560
Conditions
Cataract
Interventions
ReSTOR +3, Crystalens HD, Crystalens AO
Device
Lead sponsor
Alcon Research
Industry
Eligibility
21 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
1
States / cities
Fort Worth, Texas
Conditions
Presbyopia
Interventions
Vehicle, Pilocarpine HCl Ophthalmic Solution
Other · Drug
Lead sponsor
Allergan
Industry
Eligibility
40 Years to 55 Years
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
36
States / cities
Chandler, Arizona • Scottsdale, Arizona • Beverly Hills, California + 32 more
Conditions
Presbyopia
Interventions
Serafilcon A multifocal contact lenses, Senofilcon A multifocal contact lenses, CLEAR CARE® Cleaning & Disinfecting Solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
8
States / cities
Los Angeles, California • Oakland, California • Maitland, Florida + 5 more
Conditions
Presbyopia
Interventions
etafilcon A multifocal contact lens, etafilcon A Contact Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
35 Years to 47 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
8
States / cities
North Little Rock, Arkansas • Blue Springs, Missouri • Lake Ozark, Missouri + 5 more
Conditions
Presbyopia
Interventions
AGN-199201 ophthalmic solution, AGN-190584 ophthalmic solution, AGN-199201 Vehicle, AGN-190584 Vehicle
Drug
Lead sponsor
Allergan
Industry
Eligibility
40 Years to 55 Years
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
25
States / cities
Arcadia, California • Artesia, California • Cypress, California + 19 more
Completed Not applicable Interventional Accepts healthy volunteers Results available

Accommodative Relief for Uncomfortable Non-Presbyopes

NCT03544216
Conditions
Asthenopia
Interventions
Multifocal Contact Lens, Single Vision Contact Lens
Device
Lead sponsor
Ohio State University
Other
Eligibility
30 Years to 40 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Columbus, Ohio