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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Sepsis and Septic Shock Clear all
Not yet recruiting No phase listed Observational

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

NCT01315782
View directory record Official record
Conditions
Sepsis, Severe Sepsis, Septic Shock, Multi-organ Failure
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 10, 2025 · Synced Jun 26, 2026, 7:22 AM EDT
Completed No phase listed Observational

Reference Range for abioSCOPE® Device With the PSP Assay in a Generally Healthy Adult Population

NCT04409561
View directory record Official record
Conditions
Sepsis, Septic Shock, Healthy
Interventions
Blood collection
Device
Lead sponsor
Abionic SA
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Timeline
2021 – 2022
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 1, 2022 · Synced Jun 26, 2026, 7:22 AM EDT
Recruiting Phase 4 Interventional

Early Versus Late Adjunctive Vasopressin in Septic Shock

NCT06709573
View directory record Official record
Conditions
Sepsis, Septic Shock
Interventions
vasopressin - early initiation, vasopressin - standard initiation
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Not applicable Interventional

Restrictive Intravenous Fluids Trial in Sepsis

NCT03137446
View directory record Official record
Conditions
Septic Shock, Severe Sepsis
Interventions
Intravenous Fluid Cap
Other
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years and older
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Jun 26, 2026, 7:22 AM EDT
Terminated Phase 4 Interventional Results available

Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock

NCT02668432
View directory record Official record
Conditions
New Onset Atrial Fibrillation, Severe Sepsis, Septic Shock
Interventions
Amiodarone
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 1, 2019 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Phase 3 Interventional Results available

Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis

NCT00608322
View directory record Official record
Conditions
Sepsis
Interventions
Inhaled nitric oxide, Sham inhaled nitric oxide
Drug · Other
Lead sponsor
National Institute of General Medical Sciences (NIGMS)
NIH
Eligibility
14 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 10, 2013 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Not applicable Interventional

Thiamine, Vitamin C and Hydrocortisone in the Treatment of Septic Shock

NCT03540628
View directory record Official record
Conditions
Septic Shock
Interventions
Thiamine and Vitamin C
Dietary Supplement
Lead sponsor
Corewell Health South
Other
Eligibility
18 Years to 90 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Saint Joseph, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Not applicable Interventional

An Algorithm Driven Sepsis Prediction Biomarker

NCT03015454
View directory record Official record
Conditions
Sepsis, Septic Shock, Severe Sepsis
Interventions
Severe Sepsis Prediction, Severe Sepsis Detection
Other
Lead sponsor
Dascena
Industry
Eligibility
18 Years and older
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 22, 2021 · Synced Jun 26, 2026, 7:22 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of CPD MNV as an Aid in the Diagnosis and Risk Assessment of Sepsis (Protocol # Sepsis 1-14)

NCT02232750
View directory record Official record
Conditions
Sepsis, Severe Sepsis and Septic Shock
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 90 Years
Enrollment
1,320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 2, 2021 · Synced Jun 26, 2026, 7:22 AM EDT
Terminated Phase 2 Interventional Results available

Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148

NCT02317549
View directory record Official record
Conditions
Septic Shock
Interventions
LB1148, Placebo
Drug
Lead sponsor
Leading BioSciences, Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
26
States / cities
Mobile, Alabama • Fresno, California • Long Beach, California + 23 more
Source: ClinicalTrials.gov public record
Updated May 31, 2020 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Pharmacokinetic and Biomarker Study of Pioglitazone in Adolescents With Severe Sepsis and Septic Shock

NCT01352182
View directory record Official record
Conditions
Severe Sepsis, Septic Shock
Interventions
Pioglitazone hydrochloride
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Not listed
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Jun 26, 2026, 7:22 AM EDT
Enrolling by invitation No phase listed Observational

Delphi Septic Shock: Sub-phenotypes Using Point-of-Care Ultrasound in Patients With Septic Shock

NCT07616817
View directory record Official record
Conditions
Septic Shock, Sepsis, Shock
Interventions
Not listed
Lead sponsor
Albany Medical College
Other
Eligibility
Not listed
Enrollment
50 participants
Timeline
2025 – 2027
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Phase 1 Interventional Results available

Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study

NCT01393782
View directory record Official record
Conditions
Septic Shock
Interventions
Angiotensin II
Drug
Lead sponsor
George Washington University
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 11, 2024 · Synced Jun 26, 2026, 7:22 AM EDT
Completed No phase listed Observational Results available

Evaluating the Effect of Chronic Antihypertensive Therapy on Vasopressor Dosing in Septic Shock

NCT02884011
View directory record Official record
Conditions
Septic Shock
Interventions
Not listed
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 2, 2025 · Synced Jun 26, 2026, 7:22 AM EDT
Terminated Phase 1 Interventional

L-Carnitine Administration in Early Sepsis

NCT01193777
View directory record Official record
Conditions
Septic Shock
Interventions
L-Carnitine, Normal Saline
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
2
States / cities
Jackson, Mississippi • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 21, 2022 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Not applicable Interventional Results available

A Randomized Controlled Trial of a Conservative Fluid Balance Strategy for Patients With Sepsis and Cardiopulmonary Dysfunction (BALANCE Study)

NCT02159079
View directory record Official record
Conditions
Sepsis
Interventions
Conservative Fluid Management Strategy
Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 31, 2019 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Not applicable Interventional

Predictive algoRithm for EValuation and Intervention in SEpsis

NCT03235193
View directory record Official record
Conditions
Sepsis, Septic Shock, Severe Sepsis
Interventions
Severe Sepsis Prediction, Severe Sepsis Detection
Other
Lead sponsor
Dascena
Industry
Eligibility
18 Years and older
Enrollment
2,296 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Huntington, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 20, 2021 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Acetyl-L-Carnitine in the Treatment of Septic Shock

NCT00592488
View directory record Official record
Conditions
Septic Shock
Interventions
Acetyl-L-Carnitine
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 7, 2017 · Synced Jun 26, 2026, 7:22 AM EDT
Recruiting Not applicable Interventional

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis

NCT05975671
View directory record Official record
Conditions
Sepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced Nephropathy, Sepsis, Severe, Septic Shock, Septic Syndrome
Interventions
Multifaceted de-implementation strategy to reduce vancomycin overuse
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Not listed
Enrollment
52,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
4
States / cities
Atlanta, Georgia • Baltimore, Maryland • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Jun 26, 2026, 7:22 AM EDT
Completed No phase listed Observational

Diagnostic and Prognostic Value of Serial Procalcitonin (PCT) Measurements in Critically Ill Patients

NCT01362920
View directory record Official record
Conditions
Sepsis
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
Not listed
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 17, 2013 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Phase 1 Interventional

Alirocumab in Patients with Sepsis

NCT05469347
View directory record Official record
Conditions
Sepsis
Interventions
Alirocumab, Placebo
Drug
Lead sponsor
Jonathan Sevransky
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Micro and Macro Circulation in Sepsis

NCT05694455
View directory record Official record
Conditions
Sepsis, Septic Shock
Interventions
Starling Stroke Volume (Starling SV)- Passive Leg Raise, Microscan Sublingual Microscopy, Venous Excess Ultrasound Scoring (VExUS), Urine Collection
Diagnostic Test · Other
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years to 99 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Jun 26, 2026, 7:22 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Biomarkers in Infection

NCT02545478
View directory record Official record
Conditions
Sepsis, Infection, Inflammation
Interventions
Not listed
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
4,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2031
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial

NCT03389555
View directory record Official record
Conditions
Sepsis, Septic Shock, Metabolic Disturbance
Interventions
vitamin C, vitamin B1, hydrocortisone, Normal saline
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
205 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
13
States / cities
Phoenix, Arizona • Boston, Massachusetts • Cambridge, Massachusetts + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 15, 2021 · Synced Jun 26, 2026, 7:22 AM EDT