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ClinicalTrials.gov public records Last synced Oct 22, 2026, 9:41 AM EDT

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Showing 1–24 of 77 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Septal Defect, Heart Clear all
Completed Not applicable Interventional Results available

PREMIUM Migraine Trial

NCT00355056
View directory record Official record
Conditions
Migraine Headaches, Patent Foramen Ovale
Interventions
Sham Procedure, AMPLATZER PFO Occluder
Other · Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 65 Years
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
30
States / cities
Phoenix, Arizona • Los Angeles, California • Colorado Springs, Colorado + 23 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2020 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?

NCT03945643
View directory record Official record
Conditions
Patent Foramen Ovale, Intrapulmonary Arteriovenous Anastamosis
Interventions
Sildenafil, Placebo
Drug · Other
Lead sponsor
University of Oregon
Other
Eligibility
18 Years to 65 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Phase 2 Interventional Results available

Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt

NCT00442364
View directory record Official record
Conditions
Varicose Veins
Interventions
Polidocanol (1%) Microfoam (Varisolve), Endovenous Microfoam Occlusion
Drug · Procedure
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
7
States / cities
Los Angeles, California • Durham, North Carolina • Winston-Salem, North Carolina + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2021 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Phase 4 Interventional

Patent Foramen Ovale in Cryptogenic Stroke Study

NCT00697151
View directory record Official record
Conditions
Ischemic Stroke, Patent Foramen Ovale
Interventions
Warfarin, Aspirin
Drug
Lead sponsor
Columbia University
Other
Eligibility
30 Years to 85 Years
Enrollment
630 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 2000
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2011 · Synced Oct 22, 2026, 9:41 AM EDT
Terminated No phase listed Observational

Optimal Timing for Repair of Left to Right Shunt Lesions

NCT00229827
View directory record Official record
Conditions
Ventricular Septal Defects, Persistent Common Atrioventricular Canal
Interventions
Not listed
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 16, 2012 · Synced Oct 22, 2026, 9:41 AM EDT
Not listed Phase 1Phase 2 Interventional

Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle

NCT03079401
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome, Atrioventricular Canal
Interventions
MPC; rexlemestrocel-L
Biological
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 5 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 21, 2023 · Synced Oct 22, 2026, 9:41 AM EDT
Completed No phase listed Observational Results available

Philips Intracardiac Echocardiography (ICE) Clinical Registry

NCT04950192
View directory record Official record
Conditions
Atrial Fibrillation, Stroke, Valve Disease, Heart, Atrial Septal Defect, Patent Foramen Ovale, Mitral Valve Disease, Tricuspid Valve Disease, Aortic Valve Disease
Interventions
ICE Image guidance
Device
Lead sponsor
Philips Clinical & Medical Affairs Global
Industry
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Aurora, Colorado • Chicago, Illinois • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2025 · Synced Oct 22, 2026, 9:41 AM EDT
Terminated No phase listed Observational

ADVANCE ASO AMPLATZER™ Atrial Septal Occluder Post Market Surveillance Study

NCT02353351
View directory record Official record
Conditions
Atrial Septal Defect Secundum
Interventions
atrial septal occluder
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
602 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
65
States / cities
Birmingham, Alabama • Tucson, Arizona • Little Rock, Arkansas + 50 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2019 · Synced Oct 22, 2026, 9:41 AM EDT
Not listed Not applicable Interventional

Stitch Closure of PFO and Septal Repair

NCT03373929
View directory record Official record
Conditions
Foramen Ovale, Patent, Septal Defect, Atrial, Septal Defect, Heart
Interventions
PFO Closure Rate, Published PFO Device Closure
Device
Lead sponsor
HeartStitch.Com
Industry
Eligibility
18 Years to 65 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 14, 2017 · Synced Oct 22, 2026, 9:41 AM EDT
Not listed Not applicable Interventional

Radiation-Free Heart Catheterization Using MRI

NCT02739087
View directory record Official record
Conditions
Aortic Coarctation, Cardiomyopathy, Atrial Septal Defect, Aortic Stenosis, Post Heart Transplant Catheter Procedure, Patent Ductus Arteriosus
Interventions
MRI guided cardiac catheterization, Magnetic resonance imaging
Procedure · Device
Lead sponsor
Joshua Kanter
Other
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Oct 22, 2026, 9:41 AM EDT
Completed No phase listed Observational

Surgical Planning for Reconstruction of Complex Heart Defects

NCT00972608
View directory record Official record
Conditions
Double Outlet Right Ventricle
Interventions
Anatomic Reconstruction and Surgical Planning
Other
Lead sponsor
Emory University
Other
Eligibility
Up to 22 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 11, 2022 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional Results available

GORE® Septal Occluder Device for Patent Foramen Ovale (PFO) Closure in Stroke Patients

NCT00738894
View directory record Official record
Conditions
Stroke, Transient Ischemic Attack
Interventions
Septal Occluder Device, Antiplatelet Medical Therapy
Device · Drug
Lead sponsor
W.L.Gore & Associates
Industry
Eligibility
18 Years to 60 Years
Enrollment
664 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 20, 2020 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional Results available

Closure of Muscular Ventricular Septal Defects (VSDs) With the AMPLATZER Muscular VSD (MuVSD) Occluder - Post Approval Study

NCT00647387
View directory record Official record
Conditions
Ventricular Septal Defects
Interventions
Muscular VSD Occluder device implantation (AMPLATZER Muscular VSD Occluder)
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2024
U.S. locations
48
States / cities
Phoenix, Arizona • Los Angeles, California • Madera, California + 40 more
Source: ClinicalTrials.gov public record
Updated Feb 11, 2025 · Synced Oct 22, 2026, 9:41 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Genes Causing Ebstein's Anomaly

NCT00497705
View directory record Official record
Conditions
Heart Septal Defects, Ventricle, Heart Defects, Congenital, Double Outlet Right Ventricle, Truncus Arteriosus, Persistent
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 22, 2026, 9:41 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Clinical Proteomic Research for the Brain

NCT00983723
View directory record Official record
Conditions
Ischemic Brain Injury, Stroke, Healthy Individual, Patent Foramen Ovale (PFO), Neurovascular Injury
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
Not listed
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 23, 2013 · Synced Oct 22, 2026, 9:41 AM EDT
Completed No phase listed Observational

Magnetic Resonance Imaging of Atrial Septal Defects

NCT00498446
View directory record Official record
Conditions
Atrial Septal Defect
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Oct 22, 2026, 9:41 AM EDT
Terminated Phase 3 Interventional

Angiotensin Converting Enzyme Inhibition in Children With Mitral Regurgitation

NCT00113698
View directory record Official record
Conditions
Heart Defects, Congenital, Heart Septal Defects, Ventricular, Heart Failure, Congestive
Interventions
Enalapril, Placebo
Drug · Other
Lead sponsor
University of Utah
Other
Eligibility
Up to 18 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
6
States / cities
Boston, Massachusetts • New York, New York • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2014 · Synced Oct 22, 2026, 9:41 AM EDT
Active, not recruiting Not applicable Interventional

AMPLATZER PFO Occluder Post Approval Study

NCT03309332
View directory record Official record
Conditions
Stroke, Patent Foramen Ovale
Interventions
AMPLATZER™ PFO Occluder
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 60 Years
Enrollment
1,214 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
78
States / cities
Birmingham, Alabama • Huntsville, Alabama • Chandler, Arizona + 63 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Batten Grafting Improve Nasal Outcomes in Septoplasty and Turbinate Reduction?

NCT05287841
View directory record Official record
Conditions
Nasal Obstruction, Septal Defect, Allergic Rhinitis, Nasal Polyps, Nasal Valve Collapse
Interventions
Batten batten graft, Septoplasty, Inferior Turbinate Reduction
Procedure
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
3
States / cities
Poplar Bluff, Missouri • New York, New York • Staten Island, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional Results available

Patent Foramen Ovale Closure or Medical Therapy After Stroke - RESPECT Trial

NCT00465270
View directory record Official record
Conditions
Cryptogenic Stroke
Interventions
AMPLATZER PFO Occluder, Standard of Care - Medical Management
Device · Other
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 60 Years
Enrollment
980 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2016
U.S. locations
61
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Los Angeles, California + 52 more
Source: ClinicalTrials.gov public record
Updated Feb 18, 2019 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional Results available

Focused Cardiac Ultrasound

NCT03887286
View directory record Official record
Conditions
Ventricular Dysfunction, Pericardial Effusion, Valvular Disease, Septal Defect
Interventions
Philips EPIQ 7 ultrasound machine, Philips Lumify Broadband sector array transducer
Device
Lead sponsor
University of Miami
Other
Eligibility
Not listed
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Oct 22, 2026, 9:41 AM EDT
Withdrawn Phase 3 Interventional

Iatrogenic Atrial Septal Defect Study (iASD)

NCT04395027
View directory record Official record
Conditions
Septal Defect, Atrial
Interventions
atrial septal defect closure
Device
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 8, 2022 · Synced Oct 22, 2026, 9:41 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Study of Energy Expenditure in Infants With Ventricular Septal Defects

NCT00006272
View directory record Official record
Conditions
Heart Septal Defects, Ventricular
Interventions
Not listed
Lead sponsor
National Center for Research Resources (NCRR)
NIH
Eligibility
3 Months to 4 Months
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 1994
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 24, 2005 · Synced Oct 22, 2026, 9:41 AM EDT
Completed No phase listed Observational

Does Patent Foramen Ovale Size Matter in Men and Women

NCT03904277
View directory record Official record
Conditions
Patent Foramen Ovale
Interventions
Not listed
Lead sponsor
University of Oregon
Other
Eligibility
18 Years to 40 Years
Enrollment
28 participants
Timeline
2018 – 2023
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 1, 2023 · Synced Oct 22, 2026, 9:41 AM EDT