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ClinicalTrials.gov public records Last synced Nov 15, 2026, 8:25 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1081–1104 of 2,615 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Sleep-Wake Disorders Clear all

Conditions: Restless Legs Syndrome
Interventions: Botulinum Toxin A; Drug
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: 18 Years to 80 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Sleep Deprivation, Performance
Interventions: Military Energy Gum, Placebo Gum; Dietary Supplement
Lead sponsor: Walter Reed Army Institute of Research (WRAIR); Federal
Eligibility: 18 Years to 50 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2024
U.S. locations: 1
States / cities: Silver Spring, Maryland

Conditions: Obstructive Sleep Apnea
Interventions: Belun Ring, PSG; Device · Diagnostic Test
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 113 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 2
States / cities: Beachwood, Ohio • Cleveland, Ohio

Conditions: Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Hemophilia, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome
Interventions: The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:; Drug
Lead sponsor: Duke University; Other
Eligibility: 0 Years to 20 Years
Enrollment: 5,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2026
U.S. locations: 49
States / cities: Phoenix, Arizona • Little Rock, Arkansas • Los Angeles, California + 40 more

Conditions: Chronic Pain, Insomnia, HIV
Interventions: Brief Behavioral Treatment for Insomnia (BBTI), Brief Mindfulness Training (BMT); Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 25 Years to 65 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Hypertension, Insomnia
Interventions: Cognitive Behavioral Therapy for Insomnia (CBT-I); Behavioral
Lead sponsor: Duke University; Other
Eligibility: 30 Years to 60 Years
Enrollment: 149 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Sleep Apnea
Interventions: NightOwl; Device
Lead sponsor: Ectosense NV; Industry
Eligibility: 13 Years and older
Enrollment: 106 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 3
States / cities: Miami Lakes, Florida • Plantation, Florida

Conditions: Suicide, Depression, Anxiety, Insomnia, Agitation
Interventions: Alpha-Stim®., Montgomery-Åsberg Depression Rating Scale, Hamilton Anxiety Rating Scale, The Pittsburgh Sleep Quality Index and agitated behavior Scale; Device · Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Insomnia, Depression
Interventions: Digital CBT-I, Digital SHE; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older · Female only
Enrollment: 456 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Diabetes, Prediabetic, Prediabetes, Glucose Intolerance
Interventions: eszopiclone; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 64 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Chronobiology Disorders, Circadian Rhythm Disorders, Sleep Disorders, Circadian Rhythm
Interventions: light exposure; Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 21 Years to 30 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Sleep Disturbance, Sleep, Depression, Suicide
Interventions: Sleep Feedback + Psychoeducation, Transdiagnostic Sleep and Circadian Intervention + Bright Light (TSC+), Triple Chronotherapy (TCT+); Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 25 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Obstructive Sleep Apnea, Heart Failure; With Decompensation
Interventions: Not listed
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 80 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: San Diego, California

Conditions: Alzheimer's Disease, Insomnia
Interventions: quetiapine; Drug
Lead sponsor: University of Vermont; Other
Eligibility: 55 Years to 90 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Obstructive Sleep Apnea
Interventions: Inspire® UAS System; Device
Lead sponsor: Inspire Medical Systems, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 127 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2025
U.S. locations: 14
States / cities: Birmingham, Alabama • Los Angeles, California • Miami, Florida + 9 more

Conditions: Insomnia
Interventions: supported digital CBTI, digital CBTI; Behavioral · Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Stanford, California

Conditions: Insomnia Disorder
Interventions: education and coaching on developing healthy nighttime sleep and daytime activity behaviors; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 65 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Obesity, Overweight, Osteoarthritis, Knee, Obstructive Sleep Apnea
Interventions: Retatrutide, Placebo; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 18 Years and older
Enrollment: 2,335 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 39
States / cities: Phoenix, Arizona • Little Rock, Arkansas • Fresno, California + 33 more

Conditions: Breast Cancer, Fatigue, Sleep Disorders
Interventions: Tamoxifen, triptorelin, Exemestane; Drug
Lead sponsor: ETOP IBCSG Partners Foundation; Network
Eligibility: Up to 120 Years · Female only
Enrollment: 86 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2016
U.S. locations: 13
States / cities: Sacramento, California • Fort Collins, Colorado • Norwalk, Connecticut + 7 more

Conditions: Insomnia
Interventions: Ramelteon, Placebo; Drug
Lead sponsor: Takeda; Industry
Eligibility: 18 Years to 45 Years
Enrollment: 122 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2004
U.S. locations: 29
States / cities: Birmingham, Alabama • Jasper, Alabama • Mesa, Arizona + 26 more

Conditions: Insomnia, Sleeplessness, Transient Insomnia
Interventions: Electric stimulation of the Vestibular Nerve - "VirtuSom", Electric stim of the Vestibular Nerve - "VirtuSom" - SHAM; Device
Lead sponsor: Philips Respironics; Industry
Eligibility: 21 Years to 50 Years
Enrollment: 349 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 6
States / cities: Atlanta, Georgia • New York, New York • Rochester, New York + 2 more

Conditions: Chronic Insomnia, Primary Insomnia
Interventions: Mindfulness-Based Stress Reduction, eszopiclone; Behavioral · Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 2
States / cities: Minneapolis, Minnesota

Conditions: Sleep Disturbance
Interventions: Relaxation CD; Other
Lead sponsor: Brooke Army Medical Center; Federal
Eligibility: 18 Years to 50 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 3
States / cities: Fort Carson, Colorado • Fort Hood, Texas • Fort Sam Houston, Texas

Conditions: Tobacco Use, Tobacco Cessation, Insomnia
Interventions: Experimental health intervention, Varenicline; Behavioral · Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 2
States / cities: New Haven, Connecticut

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Botulinum Toxin to Treat Restless Legs Syndrome

Impact of Sleep Deprivation and Caffeine in Medical Professionals

Belun Ring Validation Study for Assessment of Obstructive Sleep Apnea

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain

Sleep Quality and Mechanisms of Cardiovascular Risks in Adults With Hypertension

A Validation Study of the NightOwl PAT-based Home Sleep Apnea Test

Cranial Electric Stimulation to Modify Suicide Risk Factors in Psychiatric Inpatients.

Perinatal Research on Improving Sleep and Mental Health

Sleep Effectiveness and Insulin and Glucose Homeostasis

Light Sensitization Study

Sleep and Circadian Interventions for College Students at High Risk of Suicide

Sleep Disordered Breathing in Acute Congestive Heart Failure

Quetiapine for the Treatment of Insomnia in Alzheimer's Disease

Inspire® Post-Approval Study / Protocol Number 2014-001

Clinician Training Program to Integrate Digital CBTI Into Routine Psychotherapy

Sleep Well 24 (SWELL24) Healthy Sleep-Wake Behaviors in Older Adults

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight

Brain Function in Premenopausal Women Receiving Tamoxifen With or Without Ovarian Function Suppression for Early-Stage Breast Cancer on Clinical Trial IBCSG 24-02

Long-Term Efficacy of Ramelteon on Endocrine Function in Adult Subjects With Chronic Insomnia

Evaluation of Vestibular Stimulation to Help Occasional Sleeplessness

Mindfulness Versus Pharmacotherapy for Chronic Insomnia: A Pilot Study

Sleep Disturbance in Deployed Soldiers

Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse