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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:24 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Smoking Cessation
Interventions: BIDI Stick e-cigarette; Other
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Current Smoker, Never Smoker, Tobacco Use Disorder, Former Smoker, E-cig User
Interventions: Bronchoscopy, Electronic Cigarette, Laboratory Biomarker Analysis, Questionnaire Administration; Procedure · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 45 Years
Enrollment: 142 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Smoking
Interventions: Electronic Cigarette #1, Electronic Cigarette #2; Other
Lead sponsor: R.J. Reynolds Vapor Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 1
States / cities: Lakewood, Colorado

Conditions: Alcohol Use, E-cigarette Use, Cigarette Use
Interventions: Experimental Tobacco Marketplace, Hypothetical Novel Nicotine Product Purchase Tasks; Behavioral
Lead sponsor: Mark J Rzeszutek, PhD; Other
Eligibility: 21 Years and older
Enrollment: 737 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Smoking
Interventions: Vitamin E with and without Vitamin C; Drug
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 18 Years to 35 Years
Enrollment: 99 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2000 – 2005
U.S. locations: 1
States / cities: Corvallis, Oregon

Conditions: Adverse Childhood Experiences, Nicotine Dependence, Cigarettes
Interventions: Nicotine nasal spray 0.5 mg, Placebo; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 21 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Healthy
Interventions: Not listed
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 21 Years to 35 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Biospecimen Collection, Smoking Cessation Intervention, Survey Administration; Procedure · Behavioral · Other
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 776 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Cigarette Smoking
Interventions: E-cigarette Switching, Financial Incentives; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 21 Years to 100 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Tobacco Use, Smoking
Interventions: Nicotine Pouch P1312914, 4 mg nicotine, Nicotine Pouch P1312915, 8 mg nicotine, Nicotine Pouch P1013215, 8 mg nicotine, Nicotine Pouch P1013218, 10 mg nicotine, Nicotine Pouch P1012919, 12 mg nicotine, Smoking Abstinence, Continued UB cigarette smoking; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 5
States / cities: Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more

Conditions: Smoking ( Cigarette)
Interventions: Nicotine 0.05 mg/pulse and 0.1 mg/pulse, Saline Placebo (0.5mL injection), sucralose, Sugar syrup (Placebo); Drug · Dietary Supplement
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 59 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Healthy Lifetime Non-smokers
Interventions: Propylene Glycol, vegetable glycerin, PG+VG; Other
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Cigarette Smoking, Home Access to Internet and Email, Cognitively and Physically Able to Participate, English Speaking and Reading
Interventions: Web-based smoking cessation program; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 19 Years and older
Enrollment: 1,548 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Smoking Behaviors
Interventions: Intervention ads, Control ads; Behavioral
Lead sponsor: UNC Lineberger Comprehensive Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 1,236 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Cigarette packaging, Data capture, Questionnaire administration; Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 21 Years to 69 Years
Enrollment: 115 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: E-Cig Use, Vaping
Interventions: videogame, treatment as usual; Device · Other
Lead sponsor: Yale University; Other
Eligibility: 11 Years to 17 Years
Enrollment: 287 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Milford, Connecticut

Conditions: Schizophrenia
Interventions: SPECT Imaging of Nicotinic Acetylcholine Receptors in Brain; Drug
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: Not listed
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2004
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Cigarette Smoking Behavior
Interventions: Label with constituent disclosure message, Label with litter message; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 21 Years and older
Enrollment: 784 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking, Smoking Cessation, Cigarette Smoking, Tobacco, Smoking
Interventions: QuitTXT Study, Low Contact; Behavioral
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 18 Years to 29 Years
Enrollment: 4,432 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Smoking, Smoking Behaviors, Nicotine Dependence
Interventions: E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 21 Years and older
Enrollment: 256 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Use Disorder, HIV
Interventions: PSFW+, AHA, Nicotine polacrilex; Behavioral · Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 512 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 2
States / cities: Baltimore, Maryland • The Bronx, New York

Conditions: Healthy Volunteers, Moderate to Heavy Smokers, Non-smokers
Interventions: pracinostat; Drug
Lead sponsor: Helsinn Healthcare SA; Industry
Eligibility: 18 Years and older
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Tempe, Arizona

Conditions: Smoking During Pregnancy and Postpartum, Perinatal Cigarette Smoking
Interventions: Best Practices, Financial Incentives; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 137 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: E-cigarette Use
Interventions: C-11 labeled nicotine, PET/CT imaging; Drug · Radiation
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 80 Years
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Columbus, Ohio

Search by objective public record fields.

Exploratory Study of Switching From Combustible Cigarettes to the BIDI E-cigarette

Effects of Electronic Cigarette Use on the Lungs

Comparison of Pharmacokinetic Parameters Between Adopters of Electronic Cigarettes and a Historical Sample of Combustible Cigarette Smokers

Tobacco Product Susceptibility and Substitutability by Rurality and Alcohol Use

Oxidative Stress and Vitamin E Requirements

Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking

Biology of the Oral Epithelium of E-Cigarette Smokers

A Digital Smoking Cessation Intervention for Helping American Indians and Alaska Natives Quit Smoking, IndigeQuit Trial

E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services

CSD231005 Nicotine Pouch Biomarkers of Exposure

Impact of Sweeteners on the Addictive Threshold of Nicotine

Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors

Web-based Smoking Cessation Intervention: Transition From Inpatient to Outpatient

Effective Ads for Quitting Smoking

Effects of Filter Ventilation and Ventilation Information on Product Use Behaviors in Cigarette Smokers

A Virtual Reality Videogame for E-cigarette Prevention in Teens

Imaging of Brain Receptors in Healthy Volunteers and in Patients With Schizophrenia

Impact of Cigarette Pack Constituent Disclosures

Evaluation of National Cancer Institute Young Adult Stop-Smoking Program

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

RCT of an Internet Cessation Program Plus Online Social Network for HIV+ Smokers

Study to Evaluate the Food Effect of Single-dose Bioavailability of Pracinostat in Healthy Adult Subjects

Smartphone-based Incentives Intervention to Increase Smoking Cessation During Pregnancy

Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use