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Showing 1–24 of 255 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Surgical Site Infections Clear all
Completed Not applicable Interventional

Supplemental Perioperative Oxygen to Reduce Surgical Site Infection After High Energy Fracture Surgery

NCT01798810
View directory record Official record
Conditions
Post Operative Surgical Site Infection
Interventions
Supplemental Perioperative Oxygen
Procedure
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 80 Years
Enrollment
1,171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2022
U.S. locations
2
States / cities
Phoenix, Arizona • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 21, 2026, 9:53 AM EDT
Active, not recruiting Phase 1 Interventional

Precision Antibiotic Dosing for Appendectomy

NCT06860802
View directory record Official record
Conditions
Appendicitis (Diagnosis)
Interventions
Cefoxitin
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 21, 2026, 9:53 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Floraseal Versus Iodine Impregnated Adhesive Drapes

NCT03466489
View directory record Official record
Conditions
Surgical Site Infection, Surgical Wound Infection
Interventions
Floraseal
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 21, 2019 · Synced Sep 21, 2026, 9:53 AM EDT
Completed Not applicable Interventional Results available

Negative Pressure Wound Therapy to Reduce Surgical Site Infection

NCT01905397
View directory record Official record
Conditions
Patients Undergoing Hepatopancreatobiliary Surgery
Interventions
Conventional wound therapy, Negative pressure wound therapy
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
2
States / cities
Indianapolis, Indiana • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 1, 2022 · Synced Sep 21, 2026, 9:53 AM EDT
Completed Phase 4 Interventional Results available

Skeletal Muscle and Adipose Tissue Study

NCT03190668
View directory record Official record
Conditions
Idiopathic Scoliosis
Interventions
Bolus dose of Cefazolin, Continuous Cefazolin drip, Paraspinal muscle microdialysis catheters, Subcutaneous microdialysis catheters
Drug · Device
Lead sponsor
University of Florida
Other
Eligibility
12 Years to 20 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Sep 21, 2026, 9:53 AM EDT
Completed Not applicable Interventional Results available

The Effect of Tight Glycemic Control on Surgical Site Infection Rates in Patients Undergoing Open Heart Surgery

NCT01831154
View directory record Official record
Conditions
Diabetes, Hyperglycemia, Surgical Site Infection
Interventions
Tight Glycemic, Conventional Glycemic, Standard Glycemic
Drug
Lead sponsor
James A. Haley Veterans Administration Hospital
Federal
Eligibility
21 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 23, 2017 · Synced Sep 21, 2026, 9:53 AM EDT
Terminated Not applicable Interventional Results available

"Answers in Hours" A Randomized Controlled Trial Using Microbiome Metagenomics for Bile Duct Cultures

NCT05523154
View directory record Official record
Conditions
Benign Pancreatic Neoplasm, Malignant Pancreatic Neoplasm
Interventions
Biospecimen Collection, Laboratory Procedure, Nanopore Sequencing
Procedure · Other · Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 17, 2025 · Synced Sep 21, 2026, 9:53 AM EDT
Completed Not applicable Interventional Results available

Use of 2% Chlorhexidine Cloths Reduce Surgical Site Infections

NCT02385708
View directory record Official record
Conditions
Surgical Site Infection
Interventions
2% Chlorohexidine Gluconate Standard of Care, 2% Chlorohexidine Gluconate Chin to Toe
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 29, 2019 · Synced Sep 21, 2026, 9:53 AM EDT
Completed Not applicable Interventional Results available

Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit

NCT01640925
View directory record Official record
Conditions
Cross Infection, Pneumonia, Ventilator-associated, Catheter-related Infections, Infection Due to Indwelling Urinary Catheter, Surgical Wound Infection
Interventions
Chlorhexidine gluconate, Standard bathing
Drug · Other
Lead sponsor
Joshua Swan
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 26, 2018 · Synced Sep 21, 2026, 9:53 AM EDT
Not listed Phase 4 Interventional

The Use of Ceftaroline as Surgical Prophylaxis in Surgery With Risk of MRSA Infection

NCT02307006
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Ceftaroline, Cefazolin / Vancomycin
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
Cincinnati, Ohio • West Chester, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 1, 2015 · Synced Sep 21, 2026, 9:53 AM EDT
Terminated Phase 3 Interventional Results available

D-PLEX 302: Efficacy and Safety of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery

NCT03558984
View directory record Official record
Conditions
Surgical Site Infection, Sternal Infection, Cardiac Surgery
Interventions
D-PLEX, Standard of Care
Drug · Other
Lead sponsor
PolyPid Ltd.
Industry
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Rochester, Minnesota • Huston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 21, 2026, 9:53 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Antimicrobial Dressing Versus Standard Dressing in Obese Women Undergoing Cesarean Delivery

NCT03887299
View directory record Official record
Conditions
Cesarean Section Complications, Wound Breakdown, Wound Infection, Satisfaction, Surgical Wound Infection
Interventions
ReliaTect™ Post-Op Dressing (contains chlorohexidine gluconate or CHG), Standard Wound Care
Combination Product · Other
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
154 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Sep 21, 2026, 9:53 AM EDT
Completed Not applicable Interventional

Bathing Bundle Regimen in Reducing Gynecological Surgical Site Infection in Patients Undergoing Surgery

NCT01597804
View directory record Official record
Conditions
Malignant Female Reproductive System Neoplasm
Interventions
Infection Prophylaxis and Management
Procedure
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
19 Years and older · Female only
Enrollment
435 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jul 22, 2020 · Synced Sep 21, 2026, 9:53 AM EDT
Completed Not applicable Interventional

Impact of Early Post-Operative Water Exposure on Complications of Cutaneous Surgeries

NCT01773694
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
Early Water Exposure
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
507 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 31, 2021 · Synced Sep 21, 2026, 9:53 AM EDT
Recruiting Phase 4 Interventional

Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures

NCT07225101
View directory record Official record
Conditions
Wound Closure, Brain Tumor Adult, Spine, Neurovascular, Hemorrhagic Stroke, Intracerebral, Traumatic Brain Injury
Interventions
STRATAFIX PDS and Monocryl suture
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Sep 21, 2026, 9:53 AM EDT
Terminated Not applicable Interventional

Effects of a New Antimicrobial Dressing on Wound Healing and Incidence of Sternal Wound Infections

NCT00203541
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
TELFA™ A.M.D. Island dressing
Device
Lead sponsor
Tyco Healthcare Group
Industry
Eligibility
18 Years and older
Enrollment
1,100 participants
Timeline
2004 – 2006
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 18, 2007 · Synced Sep 21, 2026, 9:53 AM EDT
Completed Not applicable Interventional

The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit

NCT00282594
View directory record Official record
Conditions
Sepsis, Respiratory Failure, Renal Failure, Surgical Site Infection
Interventions
Novolin R (human recombinant Insulin)
Drug
Lead sponsor
Genesys
Other
Eligibility
18 Years and older
Enrollment
317 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Grand Blanc, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 26, 2006 · Synced Sep 21, 2026, 9:53 AM EDT
Terminated Phase 2 Interventional Results available

Preoperative Application of Chlorhexidine to Reduce Infection With Cesarean Section After Labor

NCT03423147
View directory record Official record
Conditions
Cesarean Section, Surgical Site Infection, Nosocomial Infection
Interventions
2% chlorhexidine gluconate cloth, 4% Chlorhexidine gluconate vaginal scrub
Drug
Lead sponsor
Angela Bianco
Other
Eligibility
18 Years and older · Female only
Enrollment
319 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 21, 2026, 9:53 AM EDT
Completed No phase listed Observational

Comparison of Antibiotic Protocols in Spine Patients With Postoperative Drains

NCT01608854
View directory record Official record
Conditions
Surgical Wound Infection, Spinal Deformity, Spinal Degeneration
Interventions
Antibiotic Protocol
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
539 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2016 · Synced Sep 21, 2026, 9:53 AM EDT
Not listed Not applicable Interventional

Use of 48 Hour Course of Antibiotics to Prevent Surgical Site Infection in Obese Patients Undergoing Cesarean Delivery

NCT01194115
View directory record Official record
Conditions
Surgical Site Infection in Obese Women Undergoing C-section
Interventions
cephalexin & metronidazole, placebo
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
13 Years and older · Female only
Enrollment
475 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 10, 2011 · Synced Sep 21, 2026, 9:53 AM EDT
Completed No phase listed Observational

Rapid Identification of Key Pathogens in Wound Infection by Molecular Means

NCT00287599
View directory record Official record
Conditions
Postoperative Wound Infection, Traumatic Wound Infection, Closed Soft Tissue Abscess
Interventions
Not listed
Lead sponsor
Brentwood Biomedical Research Institute
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
2
States / cities
Los Angeles, California • Sylmar, California
Source: ClinicalTrials.gov public record
Updated Feb 7, 2012 · Synced Sep 21, 2026, 9:53 AM EDT
Recruiting Not applicable Interventional

Studying How Outpatient Water affEcts Risks With Drains (SHOWER Study)

NCT04725916
View directory record Official record
Conditions
Postoperative Wound Infection, Postoperative Complications, Surgical Site Infection, Drain Site Complication
Interventions
Showering, Restriction of Showering
Other
Lead sponsor
Sean Devitt
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 21, 2026, 9:53 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Local Anesthetic at Incision Site

NCT02483689
View directory record Official record
Conditions
Post Operative Pain, Appendicitis
Interventions
Pre Incisional Local Anesthetic, Pre-Incisional Saline, Post-Closure Local Anesthetic, Post-Closure Saline
Drug · Other
Lead sponsor
Valley Anesthesiology Consultants
Other
Eligibility
9 Years to 17 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 1, 2018 · Synced Sep 21, 2026, 9:53 AM EDT
Not yet recruiting Phase 3 Interventional

Efficacy of Integrating Next Generation Sequencing for Treatment of Surgical Site Infection After Fracture Fixation:

NCT07458230
View directory record Official record
Conditions
Next Generation Sequencing (NGS), Surgical Site Infection (SSI), Fracture Fixation
Interventions
NGS diagnostic findings
Diagnostic Test
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years to 84 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
18
States / cities
Tuscaloosa, Alabama • Los Angeles, California • San Francisco, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 21, 2026, 9:53 AM EDT