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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Sympathetic Nervous System Clear all
Terminated Not applicable Interventional Accepts healthy volunteers

Loneliness and Social Connection in Cardiovascular Disease

NCT04195620
View directory record Official record
Conditions
Cardiovascular Diseases
Interventions
High self-disclosure, Low self-disclosure
Other
Lead sponsor
Morehead State University
Other
Eligibility
18 Years to 25 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Morehead, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 28, 2022 · Synced Jul 22, 2026, 4:56 PM EDT
Suspended Not applicable Interventional

The Effect of Sympathetic Modulation on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage

NCT06443177
View directory record Official record
Conditions
Vasospasm, Cerebral, Aneurysmal Subarachnoid Hemorrhage
Interventions
Vectris trial leads and stimulation, Sham
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 22, 2026, 4:56 PM EDT
Completed Not applicable Interventional

Autonomic Recalibration

NCT06603168
View directory record Official record
Conditions
Chronic Pain (Back / Neck), Autonomic Dysregulation
Interventions
Autonomic Recalibration Treatment
Other
Lead sponsor
Edward Via Virginia College of Osteopathic Medicine
Other
Eligibility
21 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 22, 2026, 4:56 PM EDT
Recruiting No phase listed Observational

Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series

NCT07473505
View directory record Official record
Conditions
PTSD, Trauma-related Mental Health Symptoms, Moral Injury, Anxiety, Traumatic Brain Injury
Interventions
stellate ganglion block with 0.5% ropivacaine
Procedure
Lead sponsor
Reset Medical and Wellness Center
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Strongsville, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Jul 22, 2026, 4:56 PM EDT
Not yet recruiting Not applicable Interventional

Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage

NCT07577739
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm, Autonomic Nervous System Diseases
Interventions
Right-Sided Cervical Sympathetic Block at C6, Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
Procedure · Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jul 22, 2026, 4:56 PM EDT
Not listed Phase 3 Interventional

CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1

NCT02504008
View directory record Official record
Conditions
Complex Regional Pain Syndrome, Reflex Sympathetic Dystrophy
Interventions
AXS-02 (oral zoledronate), Placebo
Drug
Lead sponsor
Axsome Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
29
States / cities
Tucson, Arizona • Hot Springs, Arkansas • Encinitas, California + 26 more
Source: ClinicalTrials.gov public record
Updated Mar 22, 2018 · Synced Jul 22, 2026, 4:56 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Effects of Vaporized Marijuana on Neuropathic Pain

NCT01037088
View directory record Official record
Conditions
Neuropathic Pain, Reflex Sympathetic Dystrophy, Peripheral Neuropathy, Post-herpetic Neuralgia, Spinal Cord Injury, Multiple Sclerosis
Interventions
Mild dose cannabis, Low dose cannabis, Cannabis
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 70 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2018 · Synced Jul 22, 2026, 4:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study of Norepinephrine Levels and Sympathetic Nervous System Activity

NCT00001329
View directory record Official record
Conditions
Autonomic Nervous System Disease, Healthy, Hypertension
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1992 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 4:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans

NCT00001722
View directory record Official record
Conditions
Healthy, Obesity
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
Not listed
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2003
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 4:56 PM EDT
Suspended Early Phase 1 Interventional Accepts healthy volunteers

Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation

NCT05153395
View directory record Official record
Conditions
Healthy, Vasodilation, Insulin Resistance, Autonomic Dysfunction, Obesity
Interventions
Carbon dioxide breathing, Neurovascular Coupling, Human insulin
Other · Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 45 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jul 22, 2026, 4:56 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia

NCT02987855
View directory record Official record
Conditions
RSD (Reflex Sympathetic Dystrophy), CRPS - Complex Regional Pain Syndrome Type I, Fibromyalgia
Interventions
Lipoaspiration, ADcSVF isolation, Normal Saline IV
Procedure
Lead sponsor
Healeon Medical Inc
Industry
Eligibility
16 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Stevensville, Montana
Source: ClinicalTrials.gov public record
Updated Feb 15, 2021 · Synced Jul 22, 2026, 4:56 PM EDT
Completed No phase listed Observational

Infrared Imaging in Complex Regional Pain Syndrome

NCT05693337
View directory record Official record
Conditions
Complex Regional Pain Syndromes
Interventions
Forward Looking Infrared Radar (FLIR) thermal imaging
Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 26, 2024 · Synced Jul 22, 2026, 4:56 PM EDT
Terminated Phase 2 Interventional Results available

Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1

NCT00109772
View directory record Official record
Conditions
Complex Regional Pain Syndrome, Type I
Interventions
lenalidomide, Placebo
Drug
Lead sponsor
Celgene Corporation
Industry
Eligibility
18 Years and older
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
27
States / cities
Peoria, Arizona • La Jolla, California • Loma Linda, California + 23 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2013 · Synced Jul 22, 2026, 4:56 PM EDT
Enrolling by invitation Not applicable Interventional

Cervical Sympathetic Block in Patients With Cerebral Vasospasm

NCT05230134
View directory record Official record
Conditions
Anesthesia, Local, Cerebral Vasospasm, Subarachnoid Hemorrhage, Aneurysmal
Interventions
Cervical sympathetic block
Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Jul 22, 2026, 4:56 PM EDT
Completed No phase listed Observational

Plasma Exchange for Autoimmune Autonomic Failure

NCT00359346
View directory record Official record
Conditions
Plasma Exchange, Autonomic Failure
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 99 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jul 22, 2026, 4:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Positron Emission Tomography to Measure Pain and Pain Control

NCT00001307
View directory record Official record
Conditions
Healthy, Hyperalgesia, Pain, Peripheral Nervous System Disease
Interventions
Oxygen-15 Water, Capsaicin
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
273 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1992 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 4:56 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study

NCT01114373
View directory record Official record
Conditions
Hypertension
Interventions
Melatonin, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 64 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 25, 2016 · Synced Jul 22, 2026, 4:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Prevalence of Chapman Reflex Points in Medical Students and Their Association With Visceral Symptoms

NCT07691112
View directory record Official record
Conditions
Healthy, Autonomic Nervous System Diseases, Lymphatic Diseases, Somatic Dysfunction, Chapman Reflex Points
Interventions
Chapman Reflex Point Examination
Procedure
Lead sponsor
The Touro College and University System
Other
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Jul 22, 2026, 4:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Longitudinal Examination of Aging With a Spinal Cord Injury: Cardiovascular, Cerebrovascular and Cognitive Consequences

NCT03023163
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Longitudinal
Other
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
28 Years to 75 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 25, 2023 · Synced Jul 22, 2026, 4:56 PM EDT
Completed Not applicable Interventional

A Pilot Clinical Trial of Sympathetic Blockade With Botulinum Toxin Type A to Treat Complex Regional Pain Syndrome (CRPS): a Randomized, Double-Blind, Controlled, Crossover Trial.

NCT00637533
View directory record Official record
Conditions
Pain
Interventions
Lumbar sympathetic block with Botulinum Toxin type A
Procedure
Lead sponsor
Stanford University
Other
Eligibility
21 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jan 18, 2011 · Synced Jul 22, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Hypoglycemia and Autonomic Nervous System Function

NCT01816893
View directory record Official record
Conditions
Hypoglycemia
Interventions
Hypoglycemic hyperinsulinemic clamp, Euglycemic hyperinsulinemic clamp
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 1, 2018 · Synced Jul 22, 2026, 4:56 PM EDT
Completed Phase 2Phase 3 Interventional

Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I

NCT02402530
View directory record Official record
Conditions
Complex Regional Pain Syndrome, Type I
Interventions
Placebo, Neridronic acid 62.5 mg
Drug
Lead sponsor
Grünenthal GmbH
Industry
Eligibility
18 Years to 80 Years
Enrollment
459 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
49
States / cities
Foley, Alabama • Scottsdale, Arizona • Tucson, Arizona + 42 more
Source: ClinicalTrials.gov public record
Updated May 8, 2018 · Synced Jul 22, 2026, 4:56 PM EDT
Terminated Phase 3 Interventional Results available

Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS)

NCT03560986
View directory record Official record
Conditions
Complex Regional Pain Syndrome (CRPS)
Interventions
Neridronic acid 100 mg, Placebo
Drug
Lead sponsor
Grünenthal GmbH
Industry
Eligibility
18 Years and older
Enrollment
267 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
41
States / cities
Cottonwood, Arizona • Tempe, Arizona • Tucson, Arizona + 34 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2020 · Synced Jul 22, 2026, 4:56 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Controlling Hyperadrenergic Activity in Neurologic Injury

NCT01343329
View directory record Official record
Conditions
Traumatic Brain Injury, Dysautonomia
Interventions
Esmolol, Propranolol
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 19, 2017 · Synced Jul 22, 2026, 4:56 PM EDT