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Showing 1–24 of 190 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Tooth Demineralization Clear all
Completed Phase 3 Interventional

The Children's Amalgam Trial

NCT00065988
View directory record Official record
Conditions
Dental Caries
Interventions
Dispersed phase amalgam restoration /composite restoration
Device
Lead sponsor
Carelon Research
Other
Eligibility
6 Years to 10 Years
Enrollment
534 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2005
U.S. locations
1
States / cities
Watertown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 27, 2010 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Phase 2 Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Varnish and Strip in Adolescent and Adult Subjects

NCT03196219
View directory record Official record
Conditions
Dental Caries
Interventions
C16G2, Placebo
Drug
Lead sponsor
Armata Pharmaceuticals, Inc.
Industry
Eligibility
12 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Kalispell, Montana
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Jun 10, 2026, 7:51 PM EDT
Terminated Not applicable Interventional

Efficacy of Solventum™ Vitrebond™ Pulp Protect Liner/Base Used as a Liner/Base Under Dental Restorations

NCT07261137
View directory record Official record
Conditions
Caries, Dental, Tooth Decay, Dental Decay, Tooth Sensitivity
Interventions
Vitrebond™ Pulp Protect Liner/Base, Vitrebond™ Plus (comparator)
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
7 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children

NCT03294590
View directory record Official record
Conditions
Caries, Dental, Health Behavior
Interventions
OHT Parent targeted text messages, CWT Parent targeted text messages
Other
Lead sponsor
Boston University
Other
Eligibility
0 Months to 7 Years
Enrollment
754 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 23, 2023 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Not applicable Interventional

Delivering Geospatial Intelligence to Health Care Providers

NCT01567228
View directory record Official record
Conditions
Overweight
Interventions
CHICA GIS (enhanced electronic medical record)
Other
Lead sponsor
Indiana University
Other
Eligibility
1 Year to 21 Years
Enrollment
1,076 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 15, 2015 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Fluoride in Saliva After Use of Fluoride Toothpastes Followed by Fluoride Mouthrinses

NCT05601154
View directory record Official record
Conditions
Dental Caries
Interventions
Crest Cavity Protection toothpaste, Crest Cavity Protection toothpaste followed by Act Mint Fluoride Rinse, Colgate PreviDent 5000+ toothpaste, Colgate PreviDent 5000+ toothpaste followed by Act Mint Fluoride Rinse
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Prevention Management Model for Early Childhood Caries (MAYA Project)

NCT00066950
View directory record Official record
Conditions
Dental Caries
Interventions
Chlorhexidine gluconate, Fluoride Varnish
Drug · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 33 Years
Enrollment
361 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2005
U.S. locations
1
States / cities
San Ysidro, California
Source: ClinicalTrials.gov public record
Updated Mar 20, 2022 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Decision Aids for the Management of Suspicious Occlusal Caries Lesions

NCT02340767
View directory record Official record
Conditions
Dental Caries
Interventions
Spectra Device, DIAGNOdent
Device
Lead sponsor
The National Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
3,085 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2019 · Synced Jun 10, 2026, 7:51 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Great Beginnings for Healthy Native Smiles: An Early Childhood Caries Prevention Project

NCT04556175
View directory record Official record
Conditions
Early Childhood Caries, Dental Caries
Interventions
Oral Health, Healthy Lifestyle
Behavioral
Lead sponsor
Northern Arizona University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Kykotsmovi, Arizona • Crow Agency, Montana
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Jun 10, 2026, 7:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pandemic-adapted Caries Care Multicentre Single-group Interventional Study

NCT04666597
View directory record Official record
Conditions
Dental Caries in Children
Interventions
Modified CariesCare International management
Procedure
Lead sponsor
Universidad El Bosque, Bogotá
Other
Eligibility
3 Years to 8 Years
Enrollment
409 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Indianapolis, Indiana • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 3, 2023 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Orthodontic Varnish Microbiology Study

NCT04528134
View directory record Official record
Conditions
Dental Caries, Dental Plaque, Dental White Spot
Interventions
Extended Contact RMGI (Resin-modified Glass Ionomer) Varnish, 5% Sodium Fluoride Varnish
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years to 27 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 10, 2025 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Not applicable Interventional

Using Video Modeled Social Stories to Improve Oral Hygiene in Children With Autism Spectrum Disorder

NCT02003820
View directory record Official record
Conditions
Autism Spectrum Disorder, Dental Caries
Interventions
video modeled social story
Behavioral
Lead sponsor
Yale University
Other
Eligibility
5 Years to 14 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 7, 2016 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Phase 2, Open-Label Study for Safety, Microbiology and PK of Single or Multiple Oral C16G2 Gel Doses

NCT02254993
View directory record Official record
Conditions
Dental Caries
Interventions
C16G2
Drug
Lead sponsor
Armata Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
2
States / cities
Kalispell, Montana • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Evaluation of Anti-biofilm Effects of Ferumoxytol (Feraheme) Using an in Situ Biofilm Demineralization Model

NCT03678012
View directory record Official record
Conditions
Dental Caries
Interventions
Ferumoxytol/Hydrogen peroxide, Hydrogen Peroxide, Water
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
2
States / cities
Indianapolis, Indiana • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 18, 2018 · Synced Jun 10, 2026, 7:51 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Herbal Lollipops on Oral Bacterial Levels and DMFT/Dmft Scores of Children With Asthma Using Inhalers

NCT01147835
View directory record Official record
Conditions
Asthma, Dental Caries
Interventions
Chinese Licorice Root
Dietary Supplement
Lead sponsor
University of Nebraska
Other
Eligibility
4 Years to 16 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 22, 2023 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Not applicable Interventional

Wheelchair Maintenance Training Program

NCT03909061
View directory record Official record
Conditions
Remote Maintenance Training Program
Interventions
Wheelchair Maintenance Training
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
Not listed
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 11, 2024 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Oral Health Training Program for Pediatric Residents

NCT00846066
View directory record Official record
Conditions
Preventive Oral Health
Interventions
Hands on training, Web based training
Other
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
22 Years to 50 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 13, 2015 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

A Clinical Study to Evaluate Experimental Children's Toothpastes in an In-Situ Caries Model

NCT01607411
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
11 Years to 14 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 10, 2014 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations

NCT02889835
View directory record Official record
Conditions
Dental Caries
Interventions
Supreme Universal Restorative, Supreme Flowable Restorative, Bulk Fill Flowable Restorative
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
19 Years to 90 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Jun 10, 2026, 7:51 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers

Caries Transmission Prevention in Alaska Native Infants

NCT00067340
View directory record Official record
Conditions
Dental Caries
Interventions
Chlorhexidine mouth rinse, Xylitol chewing gum
Drug · Other
Lead sponsor
University of Washington
Other
Eligibility
Female only
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 1, 2015 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Evaluation of Implants Placed Immediately or Delayed Into Extraction Sites

NCT01244997
View directory record Official record
Conditions
Dental Caries
Interventions
Dental Implant
Procedure
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
21 Months to 65 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 21, 2010 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Not applicable Interventional Results available

High-strength Glass-ionomer Dental Restorations

NCT01523613
View directory record Official record
Conditions
Dental Caries
Interventions
Chemfil ROCK Glassionomer restoration, Fuji IX GP Extra Glassionomer restoration
Device
Lead sponsor
Mathilde Peters, DMD, PhD
Other
Eligibility
7 Years to 16 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 2, 2017 · Synced Jun 10, 2026, 7:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Shifts in the Oral Biofilm of Patients With Known Oral Health Risk Factors

NCT02885064
View directory record Official record
Conditions
Dental Caries, Gingivitis
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
8 Years to 99 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Jun 10, 2026, 7:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study on Use of Xylitol-wipes to Prevent Dental Caries

NCT01468727
View directory record Official record
Conditions
Dental Caries
Interventions
xylitol wipe, placebo wipe
Dietary Supplement
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Months to 35 Months
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 15, 2011 · Synced Jun 10, 2026, 7:51 PM EDT