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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: fNIRS Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Tracking Early Emergence of Sound Perception Impairments in FXS With Multimodal fNIRS/EEG-Preschool Age

NCT05957549
View directory record Official record
Conditions
Fragile X Syndrome
Interventions
Speech discrimination
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
24 Months to 4 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Jun 25, 2026, 9:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Neural Mechanisms of Split-belt Treadmill Adaptation in People With Multiple Sclerosis

NCT05878873
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Split-belt Treadmill, Transcutaneous Electrical Nerve Stimulation (TENS)
Behavioral · Device
Lead sponsor
Colorado State University
Other
Eligibility
18 Years to 86 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Jun 25, 2026, 9:42 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

fNIRS for Disorders of Consciousness

NCT07485361
View directory record Official record
Conditions
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Brain Injury, TBI Traumatic Brain Injury
Interventions
Functional Near-Infrared Spectroscopy Monitoring
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jun 25, 2026, 9:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Improving Locomotor Learning With Brain Stimulation

NCT06414213
View directory record Official record
Conditions
Motor Learning
Interventions
Motor Imagery (MI), Active tDCS, Sham tDCS
Behavioral · Device
Lead sponsor
Appalachian State University
Other
Eligibility
18 Years to 99 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Boone, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 2, 2025 · Synced Jun 25, 2026, 9:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Using Imaging to Assess Effects of THC on Brain Activity

NCT03655717
View directory record Official record
Conditions
Intoxication Alcohol, Intoxication THC, Intoxication Combined Alcohol THC
Interventions
Dronabinol, Ethanol, Placebo dronabinol, Placebo ethanol
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
316 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 27, 2022 · Synced Jun 25, 2026, 9:42 PM EDT
Completed Early Phase 1 Interventional

Feasibility of Near-infrared Spectroscopy to Measure Cortical Pain Pathway (Brain) Activation During Dry Needling

NCT04170803
View directory record Official record
Conditions
Shoulder Pain, Chronic Pain, Musculoskeletal Injury
Interventions
Dry Needling, Sham Dry Needling
Device · Other
Lead sponsor
Army-Baylor University Doctoral Program in Physical Therapy
Other
Eligibility
18 Years to 50 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 27, 2020 · Synced Jun 25, 2026, 9:42 PM EDT
Recruiting Not applicable Interventional

Speech and Arm Combined Exergame

NCT06817941
View directory record Official record
Conditions
Cerebral Palsy (CP), Dysarthria
Interventions
Speech only, Hand/Arm only, Speech and arm combined
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
8 Years to 17 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Jun 25, 2026, 9:42 PM EDT
Recruiting Not applicable Interventional

Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0

NCT06725550
View directory record Official record
Conditions
Sickle Cell Disease, Pain, Acupuncture, Quantitative Sensory Testing, Magnetic Resonance Imaging, Circulating Biomarkers, Electroencephalography, Functional Near-infrared Spectroscopy
Interventions
needling acupuncture, laser acupuncture
Device
Lead sponsor
Indiana University
Other
Eligibility
14 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Jun 25, 2026, 9:42 PM EDT
Terminated Not applicable Interventional

Detection of Area of Ischemia in Patients With Subacute Stroke Via a Hybrid EEG-fNIRS Brain-computer Interface

NCT03034902
View directory record Official record
Conditions
Stroke
Interventions
Combined EEG and fNIRS
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 26, 2022 · Synced Jun 25, 2026, 9:42 PM EDT
Enrolling by invitation No phase listed Observational

Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements

NCT06002100
View directory record Official record
Conditions
Depression, Major Depressive Disorder
Interventions
fNIRS measurement
Other
Lead sponsor
Kernel
Industry
Eligibility
18 Years to 75 Years
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
10
States / cities
Costa Mesa, California • La Jolla, California • Los Angeles, California + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Jun 25, 2026, 9:42 PM EDT
Terminated Phase 1 Interventional

Cerebrovascular Reactivity in American Football Players

NCT03417492
View directory record Official record
Conditions
Traumatic Brain Injury, Mild Traumatic Brain Injury, Post-Concussion Syndrome
Interventions
Sildenafil Citrate
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
40 Years to 65 Years · Male only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 20, 2022 · Synced Jun 25, 2026, 9:42 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Neural Mechanisms of the Contextual Interference Effect: A fNIRs and EEG Study

NCT01134978
View directory record Official record
Conditions
Healthy Individuals, Learning
Interventions
Practice Order
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 6, 2011 · Synced Jun 25, 2026, 9:42 PM EDT
Not yet recruiting Not applicable Interventional

VR-PAT and fNIRS to Identify CNS Biomarkers of Pain

NCT06303687
View directory record Official record
Conditions
Acute Pain, Pediatric ALL, Procedural Pain, Burns
Interventions
VR-PAT
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
6 Years to 17 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Jun 25, 2026, 9:42 PM EDT
Recruiting No phase listed Observational

Brain Connectivity Changes With Spinal Cord Stimulation and Treatment of Chronic Pain: A Resting State NIRS/EEG Study

NCT05811312
View directory record Official record
Conditions
Neuropathic Pain
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Jun 25, 2026, 9:42 PM EDT
Completed Not applicable Interventional Results available

Pain Control Using Neuromodulation in Patients Undergoing Definitive Chemoradiotherapy for Head and Neck Cancer

NCT02366611
View directory record Official record
Conditions
Cancer of Head and Neck
Interventions
Transcranial Direct Current Stimulation (tDCS)
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 75 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 21, 2021 · Synced Jun 25, 2026, 9:42 PM EDT
Not listed Early Phase 1 Interventional

Post-stroke Motor Rehabilitation Using Functional Near-infrared Spectroscopy-based Brain-computer-interface

NCT05258591
View directory record Official record
Conditions
Hemiparesis
Interventions
Axem Home
Device
Lead sponsor
Axem Neurotechnology Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 25, 2022 · Synced Jun 25, 2026, 9:42 PM EDT
Completed Not applicable Interventional

Functional Near-Infrared Spectroscopy (fNIRS) Assessing Neural Activity During Virtual Reality Walking Intervention

NCT06276894
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Motek C-Mill™ treadmill, training session with and without VR wearing the fNIRS cap
Device · Other
Lead sponsor
Craig Hospital
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Englewood, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jun 25, 2026, 9:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Testing and Calibration of Non-Invasive Optical Imaging Technology for Functional Brain Imaging

NCT01212029
View directory record Official record
Conditions
Cognition
Interventions
Behavioral measures, fNIRS Devices & Application, Physiological measures
Behavioral · Device · Other
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 99 Years
Enrollment
159 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Jun 25, 2026, 9:42 PM EDT
Completed Not applicable Interventional Results available

A Novel fNIRS Neurofeedback Intervention for Enhancement of Working Memory in Attention Deficit Hyperactivity Disorder (ADHD)

NCT04002167
View directory record Official record
Conditions
ADHD
Interventions
Neurofeedback, Cognitive training
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
7 Years to 11 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 12, 2023 · Synced Jun 25, 2026, 9:42 PM EDT
Terminated Not applicable Interventional

Neural Mechanisms of Motor Recovery With Technology Assisted Training

NCT05560867
View directory record Official record
Conditions
Hemiparesis, Stroke Sequelae
Interventions
robot-assisted training
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 25, 2024 · Synced Jun 25, 2026, 9:42 PM EDT
Not yet recruiting Not applicable Interventional

Understanding and Targeting Self-Regulatory Control in Bulimia Nervosa

NCT07581158
View directory record Official record
Conditions
Bulimia Nervosa, Feeding and Eating Disorders, Mental Disorders
Interventions
Real fNIRS Neurofeedback, Sham-Control fNIRS Neurofeedback, SmartPhone Intervention
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Jun 25, 2026, 9:42 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Multimodal Investigation of Neural Plasticity

NCT06453980
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
sham tDCS, active tDCS
Device
Lead sponsor
University of Michigan
Other
Eligibility
60 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Jun 25, 2026, 9:42 PM EDT
Completed Not applicable Interventional Results available

Child Characteristics, Neuromarkers, and Intervention Components Impacting Treatment Outcome: CCT, TF-CBT, TAU

NCT02926677
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Cue-Centered Treatment (CCT), Trauma-Focused CBT (TF-CBT), Treatment as Usual, NIRScout
Behavioral · Device
Lead sponsor
Stanford University
Other
Eligibility
7 Years to 18 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
Sacramento, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 7, 2021 · Synced Jun 25, 2026, 9:42 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Investigating Mild Cognitive Impairment in Patients And Controls With TD-fNIRS

NCT05996575
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
fNIRS measurement
Other
Lead sponsor
Kernel
Industry
Eligibility
55 Years to 85 Years
Enrollment
133 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
6
States / cities
Carlsbad, California • Costa Mesa, California • Escondido, California + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Jun 25, 2026, 9:42 PM EDT