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ClinicalTrials.gov public records Last synced Nov 14, 2026, 9:30 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 26 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Active Low-Intensity Focused Ultrasound (LIFU) Clear all

Conditions: Obsessive Compulsive Disorder (OCD)
Interventions: Low Intensity Focused Ultrasound; Device
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Alcohol Use Disorder
Interventions: Low Intensity Focused Ultrasound; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Cocaine Use Disorder (CUD)
Interventions: Low Intensity Focused Ultrasound; Device
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Alcohol Use Disorder, Chronic Pain
Interventions: Episodic Future Thinking, Control Episodic Thinking, Low-intensity Focused Ultrasound, Sham Low-intensity Focused Ultrasound; Behavioral · Device
Lead sponsor: Kirstin M Gatchalian; Other
Eligibility: 21 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Major Depressive Disorder
Interventions: Low-intensity focused ultrasound; Other
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Opioid-use Disorder, Substance Use Disorders
Interventions: Exablate Model 4000 Type 2.0/2.1; Device
Lead sponsor: InSightec; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2027
U.S. locations: 4
States / cities: Tampa, Florida • Baltimore, Maryland • New York, New York + 1 more

Conditions: Obsessive - Compulsive Disorder
Interventions: ATTN201 - Low Intensity Focused Ultrasound; Device
Lead sponsor: University of Pennsylvania; Other
Eligibility: 22 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Drug-Resistant Epilepsy, Epilepsy, Epilepsy (Treatment Refractory), Epilepsy Comorbidities, Epilepsy, Drug Resistant, Epilepsy, Generalized, Epilepsy, Focal
Interventions: Target optimization using LIFU, Serial LIFU stimulation; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Stuttering, Developmental Stuttering
Interventions: High DC LIFU, Sham; Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Opioid Use Disorder
Interventions: Low Intensity Focussed Ultrasound; Device
Lead sponsor: Ali Rezai; Other
Eligibility: 22 Years to 60 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Chronic Back Pain, Chronic Pain (Back / Neck)
Interventions: low intensity focused ultrasound (LIFU); Device
Lead sponsor: Washington D.C. Veterans Affairs Medical Center; Federal
Eligibility: 21 Years to 75 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Autism Spectrum Disorder
Interventions: Active LIFU; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 13 Years to 25 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Opioid Use Disorder
Interventions: Exablate Model 4000 Type 2.0/2.1; Device
Lead sponsor: West Virginia University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Obsessive Compulsive Disorder
Interventions: Low Intensity Focused Ultrasound, Sham (No Treatment); Device
Lead sponsor: University of Pennsylvania; Other
Eligibility: 22 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Chronic Pain
Interventions: LIFU, Sham LIFU; Device
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Pain
Interventions: Neuromodulation with low-intensity focused ultrasound; Other
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Nicotine Addiction
Interventions: Low intensity focused ultrasound with active stimulations, low intensity focused ultrasound with sham stimulations; Device
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 20 Years to 60 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Tobacco Use Disorder
Interventions: low intensity focused ultrasound (LIFU); Device
Lead sponsor: Washington D.C. Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Mild Cognitive Impairment (MCI)
Interventions: Low intensity focused ultrasound, Sham (No Treatment); Device
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 55 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Cognitive Change
Interventions: Neuromodulation with low-intensity focused ultrasound; Other
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Stroke, Visual Field Defect, Visual Field Defect Following Cerebrovascular Accident, Hemianopia, Quadrantanopia, Occipital Lobe Infarct, Visual Fields Hemianopsia
Interventions: Low-intensity focused ultrasound, Immersive virtual reality, Inactive Low-intensity focused ultrasound; Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Opioid Use Disorder, Chronic Back Pain, Anxiety
Interventions: low intensity focused ultrasound (LIFU); Device
Lead sponsor: Washington D.C. Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Schizophrenia, Auditory Hallucinations
Interventions: LIFU; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 64 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Gambling Disorder, Gambling Addiction, Gambling Problem, Gambling
Interventions: Active Low-Intensity Focused Ultrasound (LIFU), Sham Low-Intensity Focused Ultrasound (LIFU); Device
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years to 60 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2029
U.S. locations: 1
States / cities: Charlottesville, Virginia

Search by objective public record fields.

OCD LIFU Target Engagement

Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder

Low Intensity Focused Ultrasound in Cocaine Use Disorder

Decision Making in Chronic Pain and Alcohol Use Disorder

Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

SONATA Dose Duration LIFU for OCD

Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy

Noninvasive Thalamocortical Neuromodulation With Low-Intensity Focused Ultrasound for Persistent Developmental Stuttering

LIFU for Treatment for Refractory Opioid Use Disorder

Low Intensity Focused Ultrasound for Chronic Pain: High Resolution Targeting of The Human Insula

Low Intensity Focused Ultrasound in ASD

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD)

SONATA LIFU for OCD

LIFU for Chronic Pain

Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals

Non-Invasive Deep Brain Neuromodulation for Smoking Cessation

Low Intensity Focused Ultrasound for Tobacco Use Disorder: High Resolution Targeting of the Human Insula

Mild Cognitive Impairment and Neuromodulation

Study of Low-intensity Focused Ultrasound Effects on Cognitive fMRI Signals

Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke

Focused Ultrasound for the Complex Patient

LIFU Effects & Outcomes: Mechanisms Evaluating Striatal Systems Imaging (LEO MESSI)

Low-Intensity Focused Ultrasound for Gambling Disorder