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ClinicalTrials.gov public records Last synced Sep 21, 2026, 8:41 PM EDT

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Showing 1–24 of 47 matching trials from the live ClinicalTrials.gov search.
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Recruiting Phase 2 Interventional

Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer

NCT07076485
View directory record Official record
Conditions
Breast Cancer
Interventions
Ultrahypofractionated Radiation, Moderately Hypofractionated Radiation
Radiation
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
768 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
5
States / cities
Loveland, Colorado • Jacksonville, Florida • Voorhees Township, New Jersey + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 21, 2026, 8:41 PM EDT
Not listed No phase listed Observational

Schizophrenia and PTSD Project: Health, Interventions, and Risk/Resilience Evaluation(SAPPHIRE Study)

NCT00560677
View directory record Official record
Conditions
Schizophrenia, PTSD
Interventions
Not listed
Lead sponsor
Durham VA Medical Center
Federal
Eligibility
18 Years to 72 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 16, 2021 · Synced Sep 21, 2026, 8:41 PM EDT
Terminated Phase 2 Interventional Results available

Proof-of-Concept, Calcium Aluminosilicate Anti-Diarrheal (CASAD) for Treatment of Clostridium Difficile Infection

NCT01570634
View directory record Official record
Conditions
Diarrhoea, Clostridium Difficile
Interventions
Calcium Aluminosilicate Anti-Diarrheal (CASAD)
Drug
Lead sponsor
Salient Pharmaceuticals Incorporated
Industry
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Temple, Texas
Source: ClinicalTrials.gov public record
Updated Mar 7, 2013 · Synced Sep 21, 2026, 8:41 PM EDT
Completed Not applicable Interventional Results available

Post-Approval Study Protocol for the Simplify Cervical Artificial Disc

NCT04630626
View directory record Official record
Conditions
Cervical Degenerative Disc Disorder
Interventions
Simplify Disc, ACDF
Device · Other
Lead sponsor
NuVasive
Industry
Eligibility
Not listed
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
15
States / cities
Orange, California • San Diego, California • Santa Monica, California + 12 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 21, 2026, 8:41 PM EDT
Terminated Not applicable Interventional Results available

Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms

NCT04382391
View directory record Official record
Conditions
COVID, Corona Virus Infection, Respiratory Failure, Respiratory Distress Syndrome, Adult, ARDS, Human, SARS (Severe Acute Respiratory Syndrome)
Interventions
gammaCore® Sapphire (non-invasive vagus nerve stimulator), Standard of care therapies
Device · Other
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Sep 21, 2026, 8:41 PM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Aftobetin-HCl and Fluorescence Detection Measured by Sapphire II to Determine the Number and Timing of Administrations

NCT02928211
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Sapphire II, Aftobetin-HCl, Positron Emission Tomography
Device · Drug · Radiation
Lead sponsor
Cognoptix, Inc.
Industry
Eligibility
25 Years to 90 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Aug 21, 2018 · Synced Sep 21, 2026, 8:41 PM EDT
Completed Phase 3 Interventional Results available

Phase 3 Study of Sitravatinib Plus Nivolumab vs Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer

NCT03906071
View directory record Official record
Conditions
Metastatic Non-Squamous Non-Small Cell Lung Cancer
Interventions
Nivolumab, Sitravatinib, Docetaxel
Biological · Drug
Lead sponsor
Mirati Therapeutics Inc.
Industry
Eligibility
18 Years and older
Enrollment
577 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
133
States / cities
Birmingham, Alabama • Huntsville, Alabama • Glendale, Arizona + 109 more
Source: ClinicalTrials.gov public record
Updated Sep 7, 2026 · Synced Sep 21, 2026, 8:41 PM EDT
Completed Phase 3 Interventional

SOLX Titanium Sapphire Laser for Trabeculoplasty

NCT00145535
View directory record Official record
Conditions
Glaucoma, Glaucoma, Open Angle
Interventions
SOLX Titanium Sapphire Laser (TiSaLT), Argon Laser Trabeculoplasty (ALT)
Device
Lead sponsor
SOLX, Inc.
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
5
States / cities
Petaluma, California • Tampa, Florida • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2010 · Synced Sep 21, 2026, 8:41 PM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

A Study to Evaluate Safety and Tolerability of a Recombinant Herpes Zoster Vaccine

NCT05750017
View directory record Official record
Conditions
Herpes Zoster, Vaccine-Preventable Diseases
Interventions
Low Dose Recombinant Herpes Zoster Vaccine (LZ901), High Dose Recombinant Herpes Zoster Vaccine (LZ901), Placebo
Biological · Drug
Lead sponsor
Beijing Luzhu Biotechnology Co., Ltd.
Other
Eligibility
50 Years to 70 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Secaucus, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 26, 2023 · Synced Sep 21, 2026, 8:41 PM EDT
Completed Not applicable Interventional Results available

A Bilateral Dispensing Clinical Trial of Sapphire Lens Against Senofilcon A Lens Over 2 Weeks

NCT02345811
View directory record Official record
Conditions
Myopia, Hyperopia
Interventions
Sapphire, senofilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
17 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2020 · Synced Sep 21, 2026, 8:41 PM EDT
Completed Not applicable Interventional Results available

Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE)

NCT01142947
View directory record Official record
Conditions
Asthma
Interventions
beclomethasone dipropionate
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
12 Years to 56 Years
Enrollment
362 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 1, 2019 · Synced Sep 21, 2026, 8:41 PM EDT
Not listed Phase 1Phase 2 Interventional

The Efficacy of CASAD in Patients With Diarrhea Related to Medullary Thyroid Cancer

NCT01739634
View directory record Official record
Conditions
Diarrhea, Medullary Thyroid Cancer
Interventions
CASAD
Drug
Lead sponsor
Salient Pharmaceuticals Incorporated
Industry
Eligibility
Not listed
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 2, 2012 · Synced Sep 21, 2026, 8:41 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Venus Versa Diamondpolar Applicator Treatment Followed by AC Dual Applicator Treatment for Facial Acne Vulgaris

NCT02924428
View directory record Official record
Conditions
Acne Vulgaris
Interventions
Venus Versa
Device
Lead sponsor
Venus Concept
Industry
Eligibility
18 Years to 55 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 8, 2020 · Synced Sep 21, 2026, 8:41 PM EDT
Completed No phase listed Observational

SAPPHIRE Worldwide: Stenting and Angioplasty With Protection in Patients At High-Risk for Endarterectomy

NCT00403078
View directory record Official record
Conditions
Carotid Artery Disease
Interventions
Not listed
Lead sponsor
Cordis US Corp.
Industry
Eligibility
18 Years and older
Enrollment
21,008 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2014
U.S. locations
5
States / cities
Newark, Delaware • West Des Moines, Iowa • Lincoln, Nebraska + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 9, 2020 · Synced Sep 21, 2026, 8:41 PM EDT
Completed Not applicable Interventional Results available

Sapphire II PRO US Clinical Study

NCT03052530
View directory record Official record
Conditions
Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Heart Diseases, Arteriosclerosis, Cardiovascular Diseases
Interventions
Sapphire II PRO
Device
Lead sponsor
OrbusNeich
Industry
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
4
States / cities
Miami, Florida • Atlanta, Georgia • Salisbury, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated May 10, 2018 · Synced Sep 21, 2026, 8:41 PM EDT
Active, not recruiting No phase listed Observational

Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc

NCT05258435
View directory record Official record
Conditions
Cervical Disc Disease, Degenerative Disc Disease
Interventions
NuVasive Simplify Cervical Artificial Disc
Device
Lead sponsor
NuVasive
Industry
Eligibility
Not listed
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
10
States / cities
Orange, California • Santa Monica, California • Thornton, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Sep 21, 2026, 8:41 PM EDT
Completed Not applicable Interventional

Sapphire 3 CTO Study

NCT06358508
View directory record Official record
Conditions
Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Heart Diseases, Arteriosclerosis, Cardiovascular Diseases, Chronic Total Occlusion, Chronic Total Occlusion of Coronary Artery
Interventions
Sapphire 3 Coronary Dilatation Catheter
Device
Lead sponsor
OrbusNeich
Industry
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
12
States / cities
Stanford, California • Torrance, California • Atlanta, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 21, 2026, 8:41 PM EDT
Completed Not applicable Interventional

Non-invasive Vagus Nerve Stimulation for the Prevention of Migraines

NCT03716505
View directory record Official record
Conditions
Migraine Disorders
Interventions
gammaCore Sapphire active, gammaCore Sapphire Sham
Device
Lead sponsor
ElectroCore INC
Industry
Eligibility
18 Years to 75 Years
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
30
States / cities
Scottsdale, Arizona • Carlsbad, California • Palo Alto, California + 27 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2020 · Synced Sep 21, 2026, 8:41 PM EDT
Recruiting No phase listed Observational

Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty

NCT05701059
View directory record Official record
Conditions
Cervical Spondylosis With Myelopathy, Cervical Radiculopathy, Cervical Disc Herniation, Degenerative Disc Disease
Interventions
Cervical arthroplasty, Semi-Constrained Nuvasive Simplify, Unconstrained Biomet Zimmer Mobi-C
Procedure · Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 21, 2026, 8:41 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Investigational (Frequent Replacement) FRP Lens for Daily Wear

NCT02362724
View directory record Official record
Conditions
Ametropia
Interventions
Sapphire, Pearl
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
6
States / cities
San Diego, California • Torrance, California • Denver, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2020 · Synced Sep 21, 2026, 8:41 PM EDT
Completed Not applicable Interventional Results available

A Contralateral Dispensing Clinical Trial of Study Test Sapphire Lens Against Enfilcon A Silicone Hydrogel Lens

NCT02518490
View directory record Official record
Conditions
Myopia
Interventions
Sapphire Lens, enfilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Sep 21, 2026, 8:41 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

EXD-959 Orthodontic Brackets and EXD-961 Related Instruments Trial

NCT03606551
View directory record Official record
Conditions
Malocclusion
Interventions
EXD-959 Bracket System
Device
Lead sponsor
3M
Industry
Eligibility
11 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
5
States / cities
Culver City, California • Wellington, Florida • Northfield, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Sep 21, 2026, 8:41 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Impact of the M22-IPL Acne Filter on Acne Vulgaris

NCT02180282
View directory record Official record
Conditions
Acne
Interventions
M22-IPL
Device
Lead sponsor
Lumenis Be Ltd.
Industry
Eligibility
15 Years to 45 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jan 25, 2017 · Synced Sep 21, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Laser Tongue Debridement for Oral Malodor

NCT04120948
View directory record Official record
Conditions
Halitosis
Interventions
Waterlase Express Laser System, Tongue scraper
Device
Lead sponsor
New York Head & Neck Institute
Other
Eligibility
18 Years to 70 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Sep 21, 2026, 8:41 PM EDT