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Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cardiac Resynchronization Therapy (CRT) implantation Clear all
Recruiting Not applicable Interventional

Left vs Left Randomized Clinical Trial

NCT05650658
View directory record Official record
Conditions
Heart Failure, Heart Failure With Reduced Ejection Fraction, AV Block, LBBB, RBBB, Intraventricular Conduction Delay, Pacing-Induced Cardiomyopathy
Interventions
His/LBBP, BiVP
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
2,136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
57
States / cities
Gilbert, Arizona • Tucson, Arizona • Little Rock, Arkansas + 46 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 1, 2026, 10:26 PM EDT
Completed No phase listed Observational Results available

Strategic MAnagement to Optimize Response To Cardiac Resynchronization Therapy Registry

NCT03075215
View directory record Official record
Conditions
Heart Failure
Interventions
Device Programming of the Boston Scientific Cardiac Resynchronization Therapy Defibrillator (CRT-D)
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
2,044 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
29
States / cities
Anchorage, Alaska • Mesa, Arizona • Jonesboro, Arkansas + 26 more
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Sep 1, 2026, 10:26 PM EDT
Recruiting Not applicable Interventional

His-Bundle Corrective Pacing in Heart Failure

NCT05265520
View directory record Official record
Conditions
Right Bundle-Branch Block, Heart Failure, His-bundle Pacing, Cardiac Resynchronization Therapy
Interventions
His-CRT implantation, BIV-CRT implantation
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
14
States / cities
Phoenix, Arizona • Los Angeles, California • Tampa, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 1, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

Evaluation of ACUITY™ X4 Quadripolar Coronary Venous Leads and RELIANCE™ 4-FRONT Defibrillation Leads

NCT02071173
View directory record Official record
Conditions
Cardiac Resynchronization Therapy
Interventions
ACUITY X4 quadripolar coronary venous lead and RELIANCE 4-FRONT defibrillation lead
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
2,244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
96
States / cities
Birmingham, Alabama • Huntsville, Alabama • Anchorage, Alaska + 85 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Sep 1, 2026, 10:26 PM EDT
Completed No phase listed Observational Results available

SJ4 Post Approval Study in Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Defibrillator Patients

NCT00940888
View directory record Official record
Conditions
Tachyarrhythmias, Sudden Cardiac Death, Heart Failure
Interventions
SJ4 connector and RV high voltage SJ4 lead
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
1,701 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 3, 2019 · Synced Sep 1, 2026, 10:26 PM EDT
Active, not recruiting No phase listed Observational

Factors Associated With Response to Cardiac Resynchronization Therapy in Heart Failure Patients With Non-LBBB ECG Pattern

NCT06977217
View directory record Official record
Conditions
Cardiomyopathies, Heart Failure, Non-left Bundle Branch Block, Cardiac Resynchronization Therapy
Interventions
CRT-D implantation
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 1, 2026, 10:26 PM EDT
Completed Phase 4 Interventional Results available

'Effect of CRT on Defibrillation Threshold Estimates' Study

NCT00626093
View directory record Official record
Conditions
Sudden Cardiac Death
Interventions
Cardiac Resynchronization Therapy - Defibrillator (CRT-D)
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
2
States / cities
Santa Monica, California • Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 4, 2019 · Synced Sep 1, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

Real Time 3-Dimensional Echocardiography for Left Ventricular Lead Site Selection to Reduce Cardiac Resynchronization Therapy Non-Responder Rates

NCT01278030
View directory record Official record
Conditions
Heart Failure
Interventions
3D echo-guided LV lead placement
Procedure
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 18, 2019 · Synced Sep 1, 2026, 10:26 PM EDT
Recruiting Not applicable Interventional

Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment

NCT05327062
View directory record Official record
Conditions
Cardiac Resynchronization Therapy, Chronic Heart Failure, Left Bundle-Branch Block
Interventions
CRT implantation guided by XSpline, a non-invasive electrical and venous anatomy assessment
Device
Lead sponsor
XSpline S.p.A.
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
4
States / cities
Chicago, Illinois • Boston, Massachusetts • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Sep 1, 2026, 10:26 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Prospective Evaluation of Elastic Restraint to LESSen the Effects of Heart Failure (PEERLESS-HF) Trial

NCT00382863
View directory record Official record
Conditions
Heart Failure
Interventions
HeartNet Ventricular Support System, Optimal Medical/Device Therapy
Device · Drug
Lead sponsor
Paracor Medical, Inc
Industry
Eligibility
18 Years to 74 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
29
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 26 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2012 · Synced Sep 1, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

Multicenter Automatic Defibrillator Implantation Trial - Chemotherapy-Induced Cardiomyopathy

NCT02164721
View directory record Official record
Conditions
Cardiomyopathy
Interventions
Three-lead CRT-D (Defibrillator)
Device
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
9
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Tampa, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Sep 1, 2026, 10:26 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biomarkers to Predict CRT Response in Patients With HF (BIOCRT)

NCT01949246
View directory record Official record
Conditions
Heart Failure
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 2, 2022 · Synced Sep 1, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

His Bundle Pacing Versus Coronary Sinus Pacing for Cardiac Resynchronization Therapy

NCT02700425
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
CRT Pacemaker
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
8
States / cities
Los Angeles, California • Chicago, Illinois • Naperville, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced Sep 1, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

MADIT-CRT: Multicenter Automatic Defibrillator Implantation With Cardiac Resynchronization Therapy

NCT00180271
View directory record Official record
Conditions
Tachycardia, Congestive Heart Failure
Interventions
Cardiac resynchronization therapy with defibrillation, Implantable Cardioverter Defibrillator (ICD)
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
21 Years and older
Enrollment
1,820 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 18, 2018 · Synced Sep 1, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

Model 4396 Left Ventricular (LV) Lead Study

NCT00853593
View directory record Official record
Conditions
Heart Failure
Interventions
Pacing Lead
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
197 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
19
States / cities
Pasadena, California • Sacramento, California • Atlantis, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Feb 17, 2019 · Synced Sep 1, 2026, 10:26 PM EDT
Completed No phase listed Observational Results available

Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy Post Approval Registry

NCT01294449
View directory record Official record
Conditions
Heart Failure
Interventions
MADIT-CRT ICD, MADIT-CRT CRT-D
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
21 Years and older
Enrollment
394 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 3, 2014 · Synced Sep 1, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

Attain Performa(TM) Quadripolar Lead Study

NCT01751022
View directory record Official record
Conditions
Heart Failure
Interventions
Device: Attain Performa Pacing Lead (along with a standard CRT-D system)
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
1,202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
67
States / cities
Glendale, California • Riverside, California • San Diego, California + 64 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2016 · Synced Sep 1, 2026, 10:26 PM EDT
Completed No phase listed Observational

Quadripolar Pacing Post Approval Study

NCT01555619
View directory record Official record
Conditions
Heart Failure
Interventions
CRT-D System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
1,971 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
71
States / cities
Birmingham, Alabama • Huntsville, Alabama • Montgomery, Alabama + 68 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Sep 1, 2026, 10:26 PM EDT
Completed Not applicable Interventional

Optimal Coronary Sinus Lead Implantation Using Intracardiac Impedography and Magnetic Resonance Imaging

NCT01129635
View directory record Official record
Conditions
Heart Failure, Systolic, Left Bundle Branch Block
Interventions
Cardiac Resynchronization Therapy (CRT) implantation
Procedure
Lead sponsor
Emory University
Other
Eligibility
Not listed
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 20, 2015 · Synced Sep 1, 2026, 10:26 PM EDT
Completed Not applicable Interventional

Radial Strain ECHO-Guided Implantation of Cardiac Resynchronization Therapy

NCT01603706
View directory record Official record
Conditions
Ischemic Cardiomyopathy
Interventions
Echo guided implantation group
Procedure
Lead sponsor
Sheba Medical Center
Government
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 18, 2017 · Synced Sep 1, 2026, 10:26 PM EDT
Completed No phase listed Observational

RISK Stratification Using a Combination of Cardiac Troponin T and Brain Natriuretic Peptide in Patients Receiving CRT-D

NCT00453622
View directory record Official record
Conditions
Heart Failure
Interventions
Cardiac Resynchronization Therapy-Defibrillator
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 90 Years
Enrollment
222 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 3, 2019 · Synced Sep 1, 2026, 10:26 PM EDT
Terminated Not applicable Interventional

Vascular Endothelial Function and Cardiac Resynchronization Response in Patients With Heart Failure

NCT02783716
View directory record Official record
Conditions
Heart Failure
Interventions
Subcutaneous adipose tissue collection, Peripheral arterial tonometry (PAT)
Procedure · Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 17, 2023 · Synced Sep 1, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

CRT Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients

NCT01983293
View directory record Official record
Conditions
Non-left Bundle Branch Block, Ischemic or Non-ischemic Cardiomyopathy
Interventions
QLV based implant strategy, Standard of care implant strategy
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
32
States / cities
Glendale, California • Los Angeles, California • Mission Viejo, California + 25 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2019 · Synced Sep 1, 2026, 10:26 PM EDT
Withdrawn Not applicable Interventional

Patent Foramen Ovale (PFO) Closure at the Time of Endovascular Cardiac Electronic Device Implantation

NCT03232450
View directory record Official record
Conditions
Foramen Ovale, Patent
Interventions
Aspirin, Cardiovascular Implantable Device (CIED), Gore Cardioform Septal Occluder
Drug · Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 12, 2020 · Synced Sep 1, 2026, 10:26 PM EDT