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ClinicalTrials.gov public records Last synced Oct 12, 2026, 4:05 PM EDT

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Showing 97–120 of 154 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Cardiopulmonary bypass and cardiac surgery Clear all
Terminated Phase 1Phase 2 Interventional Results available

Nesiritide Use Following Cardiac Surgery in Infants

NCT00281671
View directory record Official record
Conditions
Heart Defects, Congenital, Cardiopulmonary Bypass
Interventions
nesiritide, Placebo
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 1 Year
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 27, 2020 · Synced Oct 12, 2026, 4:05 PM EDT
Recruiting Not applicable Interventional

Study of the Clinical Impact of Surgical Correction of Tricuspid Insufficiency in Implantable LVAD Patients

NCT02537769
View directory record Official record
Conditions
Tricuspid Regurgitation, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Interventions
Left ventricular assist device (LVAD), Tricuspid Valve Repair (TVR)
Device · Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Oct 12, 2026, 4:05 PM EDT
Terminated Not applicable Interventional Results available

HPI (Hypotension Prediction Index) Care Trial

NCT05083403
View directory record Official record
Conditions
Cardiopulmonary Bypass Surgery
Interventions
AcumenTM HPI Software Feature, Non-protocolized Standard of Care
Device · Other
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 12, 2026, 4:05 PM EDT
Completed No phase listed Observational Results available

Hemosonics- VCU Cardiac Surgery Clinical Study

NCT02392247
View directory record Official record
Conditions
Cardiopulmonary Bypass
Interventions
Coagulation function
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 89 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 12, 2016 · Synced Oct 12, 2026, 4:05 PM EDT
Completed Phase 1Phase 2 Interventional

BNP (Nesiritide) vs. Placebo to Protect Kidney Function in Patients Undergoing Heart Bypass Surgery.

NCT00252200
View directory record Official record
Conditions
Acute Kidney Failure
Interventions
Neseritide
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 23, 2009 · Synced Oct 12, 2026, 4:05 PM EDT
No Longer Available No phase listed Expanded access

Aprotinin US Special Access Protocol

NCT00611845
View directory record Official record
Conditions
Postoperative Hemorrhage
Interventions
Aprotinin (Trasylol, BAYA0128)
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
17
States / cities
Decatur, Alabama • Glendale, California • Pismo Beach, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2014 · Synced Oct 12, 2026, 4:05 PM EDT
Completed Not applicable Interventional

SMART Trial Longitudinal Follow-Up:Off-Pump Versus On-Pump Coronary Artery Bypass Surgery

NCT00209053
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Coronary Artery Bypass
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 16, 2013 · Synced Oct 12, 2026, 4:05 PM EDT
Completed No phase listed Observational

Coagulation Test Changes Associated With Acute Normovolemic Hemodilution in Cardiac Surgery

NCT03647644
View directory record Official record
Conditions
Coagulation Disorder, Bleeding
Interventions
Coagulation Laboratory Testing
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 7, 2019 · Synced Oct 12, 2026, 4:05 PM EDT
Terminated Phase 3 Interventional Results available

Suppression Of Atrial Fibrillation With Ranolazine After Cardiac Surgery

NCT01352416
View directory record Official record
Conditions
Heart; Dysfunction Postoperative, Cardiac Surgery
Interventions
Ranolazine, Placebo
Drug
Lead sponsor
Corewell Health East
Other
Eligibility
22 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
2
States / cities
Royal Oak, Michigan • Troy, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 6, 2017 · Synced Oct 12, 2026, 4:05 PM EDT
Recruiting No phase listed Observational

A Comparison of Renal vs Limb NIRS for Predicting Cardiac Surgery Associated Acute Kidney Injury

NCT06705855
View directory record Official record
Conditions
NIRS, Cardiac Surgery Associated - Acute Kidney Injury, Cardiac Surgery Requiring Cardiopulmonary Bypass, AKI - Acute Kidney Injury
Interventions
NIRS sensor placement
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 17, 2025 · Synced Oct 12, 2026, 4:05 PM EDT
Active, not recruiting Phase 4 Interventional

Ketamine and Kidney Injury in Cardiac Surgery

NCT05268562
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Ketamine, Propofol
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
70 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 12, 2026, 4:05 PM EDT
Terminated No phase listed Observational

The Epidemiology of Bleeding and Clotting in Patients Undergoing Heart Transplantation, Coronary Artery Bypass Graft Surgery,or Implantation of Left Ventricular Assist Devices

NCT01481012
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
Not listed
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
13
States / cities
Birmingham, Alabama • San Diego, California • Oak Lawn, Illinois + 10 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2011 · Synced Oct 12, 2026, 4:05 PM EDT
Completed Phase 1 Interventional

Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery

NCT01839812
View directory record Official record
Conditions
Adrenal Cortex Diseases, Infant Morbidity
Interventions
Cosyntropin
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
Up to 365 Days
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 16, 2014 · Synced Oct 12, 2026, 4:05 PM EDT
Terminated Phase 2 Interventional

The Use of HEMOBAG to Salvage Blood After Cardiac Surgery

NCT00176657
View directory record Official record
Conditions
Cardiopulmonary Bypass, Cardiac Diseases
Interventions
HEMOBAG Assessment
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated May 1, 2007 · Synced Oct 12, 2026, 4:05 PM EDT
Completed Phase 2 Interventional Results available

Tocilizumab in Cardiac Transplantation

NCT03644667
View directory record Official record
Conditions
Heart Transplant
Interventions
tocilizumab, Placebo, Standard of Care Triple IS
Biological · Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 75 Years
Enrollment
385 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
20
States / cities
Beverly Hills, California • La Jolla, California • Stanford, California + 15 more
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 12, 2026, 4:05 PM EDT
Completed Phase 3 Interventional Results available

In Vivo Effects of Fibrinogen Concentrate (FC) Versus Cryoprecipitate on the Neonatal Fibrin Network Structure After Cardiopulmonary Bypass (CPB)

NCT03932240
View directory record Official record
Conditions
Hemostasis
Interventions
Fibrinogen Concentrate (FC), Cryoprecipitate
Drug
Lead sponsor
Emory University
Other
Eligibility
1 Day to 30 Days
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Oct 12, 2026, 4:05 PM EDT
Terminated Not applicable Interventional Results available

Biventricular Pacing After Cardiopulmonary Bypass

NCT00498940
View directory record Official record
Conditions
Heart Failure
Interventions
Optimization Testing, Temporary Biventricular Pacing
Device
Lead sponsor
Henry M. Spotnitz
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Oct 12, 2026, 4:05 PM EDT
Withdrawn No phase listed Observational

Hematologic Ratios in Postoperative Acute Kidney Injury

NCT03658148
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
Cardiac Surgery with Cardiopulmonary Bypass
Procedure
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
0 Days to 31 Days
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 6, 2024 · Synced Oct 12, 2026, 4:05 PM EDT
Completed Not applicable Interventional Results available

Real World Expanded Multicenter Study of the MitraClip® System (REALISM)

NCT01931956
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation, Mitral Insufficiency
Interventions
MitraClip® implant
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
965 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2018
U.S. locations
38
States / cities
Los Angeles, California • Mountain View, California • Sacramento, California + 31 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Oct 12, 2026, 4:05 PM EDT
Completed No phase listed Observational

Cerebral Blood Flow During CPB During Cardiac Surgery and the Presence of Post op Delirium

NCT02084394
View directory record Official record
Conditions
Delirium
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 9, 2016 · Synced Oct 12, 2026, 4:05 PM EDT
Completed Phase 2 Interventional

MEND-CABG (MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery)

NCT00157716
View directory record Official record
Conditions
Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury, Myocardial Revascularization
Interventions
(MC-1) Pyridoxal-5'-phosphate
Drug
Lead sponsor
Medicure
Industry
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 31, 2006 · Synced Oct 12, 2026, 4:05 PM EDT
Completed Phase 3 Interventional

Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardio-Pulmonary Bypass

NCT00048308
View directory record Official record
Conditions
Cardio-pulmonary Bypass, Coronary Artery Bypass Graft
Interventions
pexelizumab
Drug
Lead sponsor
Alexion Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2002
U.S. locations
168
States / cities
Birmingham, Alabama • Mobile, Alabama • Mesa, Arizona + 120 more
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Oct 12, 2026, 4:05 PM EDT
Completed No phase listed Observational

Evaluation of Neutrophil Gelatinase-associated Lipocalin (NGAL) in Early and Evolving Acute Kidney Injury

NCT00445809
View directory record Official record
Conditions
Kidney Failure, Acute
Interventions
Not listed
Lead sponsor
Abbott RDx Cardiometabolic
Other
Eligibility
18 Years and older
Enrollment
355 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
10
States / cities
Denver, Colorado • Washington D.C., District of Columbia • Portland, Maine + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2009 · Synced Oct 12, 2026, 4:05 PM EDT
Recruiting Phase 3 Interventional

Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

NCT06096116
View directory record Official record
Conditions
Acquired Antithrombin Deficiency
Interventions
Human plasma derived antithrombin, Placebo
Drug
Lead sponsor
Octapharma
Industry
Eligibility
18 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
9
States / cities
Stanford, California • Miami, Florida • Boston, Massachusetts + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 12, 2026, 4:05 PM EDT