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Showing 1–24 of 50 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Drug therapy for HF Clear all
Completed Phase 2 Interventional

Exploratory Ph 2A, Double-Blind, Placebo-Controlled Dose Escalation Study of Safety, Tolerability, PD, & PK of HU6 for Subjects With Obese HFpEF

NCT05284617
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction
Interventions
HU6, Placebo
Drug
Lead sponsor
Rivus Pharmaceuticals, Inc.
Industry
Eligibility
40 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
15
States / cities
Beverly Hills, California • Torrance, California • Hialeah, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2024 · Synced Sep 21, 2026, 2:59 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

COPILOT-HF: Cooperative Program for ImpLementation of Optimal Therapy in Heart Failure

NCT05734690
View directory record Official record
Conditions
Heart Failure
Interventions
SGLT2i, beta blocker, ARNI, MRA, MTD, Education-First
Drug · Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
503 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 21, 2026, 2:59 PM EDT
Recruiting Not applicable Interventional

UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF

NCT07054489
View directory record Official record
Conditions
Heart Failure, Polygenic Score
Interventions
Beta blocker
Other
Lead sponsor
David Lanfear
Other
Eligibility
18 Years to 89 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 21, 2026, 2:59 PM EDT
Completed Not applicable Interventional

Palliative Care for Heart Failure Patients

NCT01519479
View directory record Official record
Conditions
Heart Failure
Interventions
Palliative Care Consultation, Control
Other
Lead sponsor
Allina Health System
Other
Eligibility
18 Years and older
Enrollment
232 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 17, 2019 · Synced Sep 21, 2026, 2:59 PM EDT
Completed Not applicable Interventional Results available

Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure (BETTER CARE-HF)

NCT05275920
View directory record Official record
Conditions
Heart Failure, Heart Failure With Reduced Ejection Fraction
Interventions
Best Practice Alert (BPA), In-Basket Message
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
2,211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Sep 21, 2026, 2:59 PM EDT
Completed Not applicable Interventional

Mobile Application for Patient Engagement and Physician-Directed Remote Management of Heart Failure

NCT06750549
View directory record Official record
Conditions
Heart Failure
Interventions
ENGAGE-HF Mobile Application
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
3
States / cities
Stanford, California • Baltimore, Maryland • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 21, 2026, 2:59 PM EDT
Terminated Not applicable Interventional Results available

OptiVol for Precision Medical Management of Heart Failure

NCT04206501
View directory record Official record
Conditions
Ischemic and Non-ischemic Cardiomyopathy
Interventions
Medtronic ICD with Opti Vol-Monitor
Device
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 85 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Sep 21, 2026, 2:59 PM EDT
Terminated Phase 3 Interventional Results available

International Study to Determine if AdreView Heart Function Scan Can be Used to Identify Patients With Mild or Moderate Heart Failure (HF) That Benefit From Implanted Medical Device

NCT02656329
View directory record Official record
Conditions
Heart Failure
Interventions
Iobenguane I -123 Injection, Implantable Cardioverter Defibrillator, Thyroid blocking
Drug · Device
Lead sponsor
GE Healthcare
Industry
Eligibility
18 Years and older
Enrollment
395 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
29
States / cities
Birmingham, Alabama • Bakersfield, California • La Mesa, California + 24 more
Source: ClinicalTrials.gov public record
Updated May 21, 2019 · Synced Sep 21, 2026, 2:59 PM EDT
Not listed Not applicable Interventional

Veterans Affairs Pharmacist Heart Failure Medication Titration Project 1

NCT06099808
View directory record Official record
Conditions
Heart Failure
Interventions
Audit and Feedback Emails, Patient Specific Targets, Educational Resources
Other
Lead sponsor
Stanford University
Other
Eligibility
Not listed
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2024 · Synced Sep 21, 2026, 2:59 PM EDT
Terminated Phase 4 Interventional Results available

Evaluating Metabolic Mechanisms of Ertugliflozin in Diabetes & Heart Failure

NCT04071626
View directory record Official record
Conditions
Heart Failure, Diastolic, Diabetes Mellitus, Type 2
Interventions
Ertugliflozin 5 mg, Placebo oral tablet
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 12, 2023 · Synced Sep 21, 2026, 2:59 PM EDT
Completed Not applicable Interventional Results available

REALIsM-HF Pilot Study

NCT03507439
View directory record Official record
Conditions
Heart Failure
Interventions
AVIVO Mobile Patient Management (MPM) System, VitalPatch biosensor, DynaPort Move Monitor
Device
Lead sponsor
Bayer
Industry
Eligibility
45 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 21, 2026, 2:59 PM EDT
Completed Not applicable Interventional

Use of NT-proBNP Testing to Guide Heart Failure Therapy in the Outpatient Setting.

NCT00351390
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
Drug therapy for HF, NT-proBNP guided HF therapy
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years and older
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 24, 2019 · Synced Sep 21, 2026, 2:59 PM EDT
Withdrawn Not applicable Interventional

Aliskiren and Renin Inhibition in Diastolic Heart Failure

NCT00773084
View directory record Official record
Conditions
Diastolic Heart Failure
Interventions
Aliskiren plus spironolactone vs. Lisinopril plus spironolactone
Drug
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
21 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated May 11, 2015 · Synced Sep 21, 2026, 2:59 PM EDT
Completed No phase listed Observational

A Study of Accelerated Guideline-Directed Medical Therapy for Heart Failure

NCT07217106
View directory record Official record
Conditions
Heart Failure
Interventions
Not listed
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
342 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Sep 21, 2026, 2:59 PM EDT
Completed Not applicable Interventional Results available

Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure

NCT04452149
View directory record Official record
Conditions
Heart Failure NYHA Class II, Heart Failure NYHA Class III
Interventions
Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware download, Medication intervention, Not Randomized to Device or Medication Intervention
Device · Other
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
826 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
53
States / cities
Mesa, Arizona • Jonesboro, Arkansas • Mission Viejo, California + 47 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 21, 2026, 2:59 PM EDT
Completed Not applicable Interventional Results available

A Pilot Study: Metformin Therapy in Heart Failure Patients With Early Diabetes or at High Risk of Developing Diabetes (Pre-Diabetes)

NCT01573949
View directory record Official record
Conditions
Diabetes, Heart Failure
Interventions
Metformin
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 90 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 3, 2020 · Synced Sep 21, 2026, 2:59 PM EDT
Not yet recruiting Not applicable Interventional

Pharmacist-Assisted Titration of Rx to Implement Optimal Medical Therapy for Heart Failure

NCT07714239
View directory record Official record
Conditions
Heart Failure, Heart Failure, Systolic
Interventions
Pharmacist/Cardiologist Virtual Team Digital Consultation
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
585 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 21, 2026, 2:59 PM EDT
Enrolling by invitation Not applicable Interventional

Veterans Affairs Pharmacist Heart Failure Medication Titration Project 2

NCT07460219
View directory record Official record
Conditions
Quality Improvement, Pharmacotherapy, Heart Failure
Interventions
Education Only, Education and Feedback (E+F), Primary Care Referral Nudges
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 21, 2026, 2:59 PM EDT
Not listed Not applicable Interventional

Community Pharmacy Medication Therapy Management for Heart Failure

NCT03608085
View directory record Official record
Conditions
Heart Failure
Interventions
Pharmacist Heart failure MTM training, Patient Heart failure MTM intervention
Behavioral
Lead sponsor
Providence VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
2
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 10, 2021 · Synced Sep 21, 2026, 2:59 PM EDT
Completed Not applicable Interventional

A Trial to Evaluate Medically Tailored Meals With Patients With Heart Failure

NCT04289181
View directory record Official record
Conditions
Heart Failure
Interventions
Medically Tailored Meals
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Sep 21, 2026, 2:59 PM EDT
Recruiting Phase 2 Interventional

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

NCT06991257
View directory record Official record
Conditions
Heart Failure
Interventions
Placebo, Low Dose PF-07328948, Medium Dose PF-07328948, High Dose PF-07328948
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 79 Years
Enrollment
620 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
28
States / cities
Beverly Hills, California • Lake Forest, California • Santa Maria, California + 17 more
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Sep 21, 2026, 2:59 PM EDT
Completed Not applicable Interventional Results available

Veterans Intensive Personalized Treatment in Heart Failure

NCT01404988
View directory record Official record
Conditions
Heart Failure
Interventions
Telephone-Delivered BI, Telephone-Delivered BEI, Telephone-Delivered API
Behavioral · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
21 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 24, 2015 · Synced Sep 21, 2026, 2:59 PM EDT
Active, not recruiting No phase listed Observational

Left Atrial Pressure-Guided Heart Failure Optimization During Atrial Fibrillation Ablation (LAP AF-HF)

NCT07594886
View directory record Official record
Conditions
Atrial Fibrillation (AF), Heart Failure, Catheter Ablation, Guideline Implementation
Interventions
LAP-Triggered Heart Failure Optimization Pathway
Behavioral
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 21, 2026, 2:59 PM EDT
Completed Phase 3 Interventional Results available

Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI

NCT02924727
View directory record Official record
Conditions
Acute Myocardial Infarction
Interventions
LCZ696 (sacubitril/valsartan), Ramipril, Placebo of LCZ696, Placebo of ramipril, Valsartan, Placebo of valsartan
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
5,669 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
81
States / cities
Birmingham, Alabama • Huntsville, Alabama • Gilbert, Arizona + 74 more
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Sep 21, 2026, 2:59 PM EDT