Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 5, 2026, 6:05 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 33 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Higher PEEP Clear all

Conditions: Critical Illness, Hypoxia, Respiratory Failure
Interventions: End-tidal oxygen monitor; Device
Lead sponsor: Sydney Local Health District; Government
Eligibility: 18 Years and older
Enrollment: 1,400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 3
States / cities: Minneapolis, Minnesota • Albuquerque, New Mexico • The Bronx, New York

Conditions: Acute Respiratory Distress Syndrome, Acute Lung Injury
Interventions: Recruitment maneuver; Procedure
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 1 Month to 18 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Anesthesia, Congenital Heart Disease
Interventions: Low Vt protocol, High Vt protocol; Procedure
Lead sponsor: University of Pittsburgh; Other
Eligibility: Not listed
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
Interventions: ECMO support, PROSpect protocolized therapies; Device · Other
Lead sponsor: University of Michigan; Other
Eligibility: 14 Days to 20 Years
Enrollment: 550 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 72
States / cities: Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 62 more

Conditions: Spinal Cord Injuries
Interventions: High tidal volume, Low tidal volume; Device
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 2
States / cities: Englewood, Colorado • Houston, Texas

Conditions: Acute Lung Injury, Adult Respiratory Distress Syndrome
Interventions: Low-tidal-volume ventilation, Airway Pressure Release Ventilation (APRV); Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Acute Lung Injury, Adult Respiratory Distress Syndrome, Kidney Injury
Interventions: Volume-Cycled Assist-Control (AC) mode, Airway Pressure Release Ventilation (APRV) mode; Device
Lead sponsor: University of Tennessee, Chattanooga; Other
Eligibility: 18 Years to 85 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 1
States / cities: Chattanooga, Tennessee

Conditions: Infant, Newborn, Diseases, Other Preterm Infants, Infant, Small for Gestational Age, Premature Birth, Bronchopulmonary Dysplasia, Retinopathy of Prematurity
Interventions: Surfactant, Continuous Positive Airway Pressure (CPAP), Supplemental oxygen with target saturation of 85 to 89%, Supplemental oxygen with target saturation of 91 to 95%; Drug · Device
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: 24 Weeks to 27 Weeks
Enrollment: 1,316 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2016
U.S. locations: 22
States / cities: Birmingham, Alabama • Palo Alto, California • San Diego, California + 18 more

Conditions: Brain Death, Organ Donation, Organ Transplant Failure or Rejection
Interventions: Open lung protective ventilation, Conventional ventilation; Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 13 Years and older
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 4
States / cities: Los Angeles, California • Palo Alto, California • San Francisco, California + 1 more

Conditions: Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
Interventions: Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL), Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS), Early Cohort corticosteroid dose, Extended Cohort corticosteroid dose, Usual care without routine corticosteroids, Usual care without extending corticosteroids, Usual care with fludrocortisone, Usual care without fludrocortisone, Drug 4 mL:, Drug 40 mg:, PEEP-20, PEEP-AOP, PEEP-10, VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation, Electrical impedance tomography (EIT), no treatment / intervention arm is involved., Usual care, Early Routine IMT; Other · Drug
Lead sponsor: University Health Network, Toronto; Other
Eligibility: 18 Years and older
Enrollment: 6,250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 27
States / cities: Tucson, Arizona • Los Angeles, California • San Diego, California + 20 more

Conditions: Infant, Newborn, Disease, Hypoxia, Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Interventions: Continuous positive airway pressure, Nasal Cannula; Procedure
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: Not listed
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Transient Tachypnea of the Newborn
Interventions: High Flow Nasal Cannula, Bubble Nasal CPAP; Other
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: Up to 24 Hours
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: New York, New York

Conditions: Morbid Obesity, Surgery, General Anesthesia
Interventions: Higher PEEP, Lower PEEP; Procedure
Lead sponsor: Technische Universität Dresden; Other
Eligibility: 18 Years and older
Enrollment: 2,013 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 2
States / cities: Boston, Massachusetts • Rochester, Minnesota

Conditions: Acute Respiratory Distress Syndrome in Children
Interventions: Either supine or prone positioning and either CMV or HFOV; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 2 Weeks to 20 Years
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2027
U.S. locations: 28
States / cities: Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 24 more

Conditions: Acute Respiratory Distress Syndrome
Interventions: Ventilator settings; Other
Lead sponsor: University of Medicine and Dentistry of New Jersey; Other
Eligibility: 18 Years to 65 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Newark, New Jersey

Conditions: Respiratory Complication, Obstructive Sleep Apnea
Interventions: Sugammadex 100 MG/ML [Bridion]; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 12,248 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Acute Respiratory Distress Syndrome
Interventions: Esophageal-pressure guided mechanical ventilation, High PEEP mechanical ventilation; Other
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 16 Years and older
Enrollment: 202 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 10
States / cities: La Jolla, California • Stanford, California • Orlando, Florida + 6 more

Conditions: Acute Respiratory Distress Syndrome (ARDS)
Interventions: SensorMedics 3100B High Frequency Oscillatory Ventilator, Lung Protective Ventilation; Device · Procedure
Lead sponsor: Canadian Critical Care Trials Group; Other
Eligibility: 16 Years to 85 Years
Enrollment: 548 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 8
States / cities: Denver, Colorado • Orlando, Florida • Ann Arbor, Michigan + 5 more

Conditions: Bronchiolitis, Viral, Pneumonia, Viral, Pneumonia, Bacterial
Interventions: Helmet CPAP; Device
Lead sponsor: Columbia University; Other
Eligibility: 1 Month to 5 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Orthopedic Surgery, Ventilation
Interventions: Low tidal Volume, High tidal Volume, Low PEEP, High PEEP; Procedure
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 2,860 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: One-Lung Ventilation
Interventions: PEEP level, Use of recruitment maneuvers; Procedure
Lead sponsor: Technische Universität Dresden; Other
Eligibility: 18 Years and older
Enrollment: 2,200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 3
States / cities: Boston, Massachusetts • New York, New York • Cleveland, Ohio

Conditions: ARDS, Human, Lung Injury, Acute, Respiratory Distress Syndrome, Mechanical Ventilation Complication, Alveolar Edema, Right Heart Failure, Right Ventricular Dysfunction
Interventions: PEEP ARDSnet, PEEP LRM; Procedure
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 85 Years
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Acute Respiratory Distress Syndrome, ARDS
Interventions: Usual care, PEEP titration by EIT; Other · Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Acute Respiratory Distress Syndrome (ARDS)
Interventions: Not listed
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 367 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: New Haven, Connecticut

Search by objective public record fields.

End-Tidal Oxygen for Intubation in the Emergency Department

Efficacy and Safety of a Lung Recruitment Protocol in Children With Acute Lung Injury

Fontan Physiology Ventilation Strategy

ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)

Comparison of Low and High Tidal Volumes in Acute Spinal Cord Injury

Acute Lung Injury Ventilator Evaluation (ALIVE)

Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation

Surfactant Positive Airway Pressure and Pulse Oximetry Trial

Goal of Open Lung Ventilation in Donors

Platform of Randomized Adaptive Clinical Trials in Critical Illness

CPAP Or Nasal Cannula Oxygen for Preterm Infants: A Randomized Controlled Trial

High Flow Nasal Cannula Versus Bubble Nasal CPAP for the Treatment of Transient Tachypnea of the Newborn in Infants ≥ 35 Weeks Gestation

Protective Ventilation With Higher Versus Lower PEEP During General Anesthesia for Surgery in Obese Patients

PROSpect: Prone and Oscillation Pediatric Clinical Trial

The Effects of Different Ventilator Strategies on Inflammation and Injury in Normal Lungs

Applying Best Clinical Practices to Patients at High Risk of Respiratory Complications

EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures

The Oscillation for Acute Respiratory Distress Syndrome (ARDS) Treated Early (OSCILLATE) Trial

Pediatric Helmet CPAP Pilot Study

Ventilation Strategy During General Anesthesia for Orthopedic Surgery: A Quality Improvement Project

Protective Ventilation With High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery

Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients

Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distress Syndrome

The Relationship Between Positive End Expiratory Pressure and Cardiac Index in Patients With Acute Respiratory Distress Syndrome (ARDS) Managed on a Fluid Protocol