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ClinicalTrials.gov public records Last synced Oct 15, 2026, 4:07 PM EDT

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Showing 433–456 of 865 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Knee Osteoarthritis Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis

NCT06105788
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Pain Chronic, Central Pain Syndrome
Interventions
Exercise
Other
Lead sponsor
University of Texas, El Paso
Other
Eligibility
45 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Dec 16, 2024 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Phase 3 Interventional Results available

Study of Meloxicam Capsules to Treat Osteoarthritis Pain

NCT01787188
View directory record Official record
Conditions
Osteoarthritis
Interventions
Meloxicam Test Capsules, Placebo Capsules
Drug
Lead sponsor
Iroko Pharmaceuticals, LLC
Industry
Eligibility
40 Years and older
Enrollment
403 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
40
States / cities
Birmingham, Alabama • Carmichael, California • Pismo Beach, California + 31 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2015 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Not applicable Interventional

Effects of Mindfulness-Based Stress Reduction on Knee Osteoarthritis

NCT03527849
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Mindfulness-Based Stress Reduction, Health Enhancement Program
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
50 Years to 80 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Dec 22, 2020 · Synced Oct 15, 2026, 4:07 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Digital Care Programs for Musculoskeletal Health

NCT05417685
View directory record Official record
Conditions
Musculoskeletal Diseases
Interventions
Acute and post-acute, Chronic, Post-surgical
Device
Lead sponsor
Sword Health, SA
Industry
Eligibility
18 Years and older
Enrollment
300,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2032
U.S. locations
1
States / cities
Draper, Utah
Source: ClinicalTrials.gov public record
Updated Dec 6, 2024 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Effect of Different Injection Regimens of Autologous Conditioned Plasma for Knee Osteoarthritis

NCT03889925
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Hyaluronan, Autologous conditioned plasma
Drug · Biological
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
30 Years to 80 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Oct 15, 2026, 4:07 PM EDT
Terminated Not applicable Interventional Results available

Uniglide™ Mobile Bearing Unicondylar Knee System vs the Uniglide™ Fixed Bearing Unicondylar Knee System

NCT00740376
View directory record Official record
Conditions
Osteoarthritis
Interventions
Uniglide Mobile Bearing Unicondylar Knee System, Uniglide Fixed Bearing Unicondylar Knee System
Device
Lead sponsor
Corin
Industry
Eligibility
40 Years to 80 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
6
States / cities
La Quinta, California • Clearwater, Florida • Lexington, Kentucky + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2019 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Phase 2 Interventional Results available

Fasitibant Intra-articular Injection in Patients With Symptomatic Osteoarthritis of the Knee

NCT02205814
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Fasitibant- low dose, Fasitibant- intermediate dose, Fasitibant- high dose, Placebo comparator
Drug
Lead sponsor
Menarini Group
Industry
Eligibility
40 Years to 80 Years
Enrollment
436 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
9
States / cities
Tucson, Arizona • Englewood, Colorado • DeLand, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 3, 2015 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Not applicable Interventional Results available

Mobility Optimization Through Velocity Exercise

NCT00844558
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Gait Training, Control
Other
Lead sponsor
University of Iowa
Other
Eligibility
60 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 6, 2016 · Synced Oct 15, 2026, 4:07 PM EDT
Not listed Not applicable Interventional

Safety and Effectiveness Study of a Non-Crosslinked HA Alkylamide HYADD(TM) 4 Hydrogel for Osteoarthritis of the Knee

NCT02187549
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
HYMOVIS, Placebo
Device
Lead sponsor
Fidia Farmaceutici s.p.a.
Industry
Eligibility
40 Years and older
Enrollment
332 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
21
States / cities
Birmingham, Alabama • Brimingham, Alabama • Phoenix, Arizona + 17 more
Source: ClinicalTrials.gov public record
Updated Oct 5, 2015 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Phase 4 Interventional Results available

The Effect of Intra-articular Bilateral Knee Injections of Zilretta on Performance Measures in Adults With Knee OA

NCT03895840
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Zilretta
Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
30 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Not applicable Interventional

Intra-articular Autologous Bone Marrow Aspirate Injection for Knee Osteoarthritis

NCT03130335
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
BMA Injection, BMA
Procedure · Biological
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 79 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2020 · Synced Oct 15, 2026, 4:07 PM EDT
Not listed Not applicable Interventional

A Controlled Comparison of Pulsed Radiofrequency Vs Physical Therapy on Treating Chronic Knee Osteoarthritis

NCT02294864
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Percutaneous Pulsed Radiofrequency, Physical Therapy
Device · Procedure
Lead sponsor
VA Long Beach Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Dec 23, 2015 · Synced Oct 15, 2026, 4:07 PM EDT
Recruiting Phase 3 Interventional

AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

NCT07509307
View directory record Official record
Conditions
Obesity, Overweight, Osteoarthritis, Knee
Interventions
NNC0487-0111, Placebo (matched to NNC0487-0111)
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
19
States / cities
Escondido, California • Lancaster, California • Palm Springs, California + 14 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Phase 3 Interventional Results available

A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip

NCT03161093
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Fasinumab, Naproxen, Fasinumab-matching placebo, Naproxen-matching placebo
Drug
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
3,307 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
58
States / cities
Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 50 more
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Not applicable Interventional

Effects of Transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound on Osteoarthritis Pain of the Knee

NCT01404052
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2020 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Not applicable Interventional

Acupuncture for Pain and Sleep Disturbance in Knee Osteoarthritis

NCT00694447
View directory record Official record
Conditions
Sleep, Pain
Interventions
Acupuncture
Procedure
Lead sponsor
Emory University
Other
Eligibility
55 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 21, 2013 · Synced Oct 15, 2026, 4:07 PM EDT
Active, not recruiting Phase 2Phase 3 Interventional

A Phase 2b/3a Study to Evaluate the Efficacy and Safety of JointStem in Patients Diagnosed as Knee Osteoarthritis

NCT04368806
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
JointStem, Placebo Control
Drug · Other
Lead sponsor
Nature Cell Co. Ltd.
Industry
Eligibility
18 Years and older
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
5
States / cities
El Cajon, California • La Mesa, California • Napa, California + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 15, 2026, 4:07 PM EDT
Completed No phase listed Observational Results available

A Biologic Joint Replacement Strategy to Treat Patients With Severe Knee Trauma and Post-Traumatic Knee Osteoarthritis

NCT03257371
View directory record Official record
Conditions
Post-traumatic Osteoarthritis
Interventions
Not listed
Lead sponsor
James Stannard
Other
Eligibility
18 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Phase 3 Interventional Results available

Tanezumab In Osteoarthritis Of The Knee (2)

NCT00830063
View directory record Official record
Conditions
Arthritis, Osteoarthritis
Interventions
tanezumab 10 mg, tanezumab 5 mg, naproxen, placebo
Biological · Drug · Other
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
832 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
94
States / cities
Anniston, Alabama • Mesa, Arizona • Paradise Valley, Arizona + 72 more
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain

NCT00361504
View directory record Official record
Conditions
Osteoarthritis, Hip, Osteoarthritis, Knee, Lower Back Pain, Pain
Interventions
Oxycodone CR, Tapentadol (CG5503) ER
Drug
Lead sponsor
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Industry
Eligibility
18 Years and older
Enrollment
1,123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
40
States / cities
Mesa, Arizona • Tucson, Arizona • Anaheim, California + 37 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2014 · Synced Oct 15, 2026, 4:07 PM EDT
Completed No phase listed Observational

Outcomes Following Total Knee Arthroplasty

NCT02364011
View directory record Official record
Conditions
Osteoarthritis
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 90 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Phase 3 Interventional Results available

A Study of Duloxetine in Patients With Osteoarthritis Knee Pain

NCT00945945
View directory record Official record
Conditions
Osteoarthritis Knee Pain
Interventions
Duloxetine (DLX), Placebo (PLA)
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
40 Years and older
Enrollment
424 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
10
States / cities
Montgomery, Alabama • Phoenix, Arizona • Spring Valley, California + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 8, 2011 · Synced Oct 15, 2026, 4:07 PM EDT
Completed Phase 2 Interventional Results available

A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain

NCT01619839
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
NKTR-181, Placebo
Drug
Lead sponsor
Nektar Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
296 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
34
States / cities
Mobile, Alabama • Tucson, Arizona • Garden Grove, California + 29 more
Source: ClinicalTrials.gov public record
Updated Aug 2, 2021 · Synced Oct 15, 2026, 4:07 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Evaluating the Efficacy of Lateral Heel Wedges of Osteoarthritis of the Knee

NCT02254473
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Wedge Insert, Flat Insert
Other
Lead sponsor
HealthPartners Institute
Other
Eligibility
30 Years to 100 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 20, 2019 · Synced Oct 15, 2026, 4:07 PM EDT