Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Oct 14, 2026, 1:44 PM EDT

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Showing 121–144 of 865 matching trials from the live ClinicalTrials.gov search.
Conditions
Osteoarthritis
Interventions
Physical Therapy, Standing
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
394 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Knee Osteoarthritis
Interventions
Implementation Strategy: Foundational REP, Implementation Strategy: Enhanced REP (enREP)
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Conditions
Osteoarthritis, Knee
Interventions
QUC398, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
40 Years to 80 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
3
States / cities
Tampa, Florida • Boston, Massachusetts • Morehead City, North Carolina
Completed Not applicable Interventional Results available

Calypso Knee System Clinical Study

NCT03671213
Conditions
Osteoarthritis, Knee
Interventions
Calypso Knee System (Implantable Shock Absorber)
Device
Lead sponsor
Moximed
Industry
Eligibility
25 Years to 65 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
5
States / cities
Columbia, Missouri • New York, New York • Columbus, Ohio + 2 more
Conditions
Knee Arthroplasty
Interventions
Total Knee Arthroplasty, MAKO® Robot Assisted Medial Knee Arthroplasty, RESTORIS Multicompartmental Knee System, Depuy Knee Replacement System, Stryker® Knee Replacement System
Procedure · Device
Lead sponsor
Northwest Surgical Specialists, Vancouver
Other
Eligibility
21 Years to 80 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
1
States / cities
Vancouver, Washington
Conditions
Osteoarthritis of the Knee, Type 2 Diabetes Mellitus
Interventions
FX006 32 mg, TCA IR 40 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
40 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
8
States / cities
Anaheim, California • El Cajon, California • North Hollywood, California + 5 more
Conditions
Low Back Pain, Knee Osteoarthritis
Interventions
Ischemic Preconditioning, Sham Intervention
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
50 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Osteoarthritis (OA) of the Knee
Interventions
TPX-100 200mg, Once weekly for 4 weeks, PBS
Drug · Other
Lead sponsor
OrthoTrophix, Inc
Industry
Eligibility
50 Years to 80 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
33
States / cities
Scottsdale, Arizona • Tucson, Arizona • Carrolton, California + 26 more
Conditions
Knee Osteoarthritis
Interventions
SOLUGEL, Placebo
Dietary Supplement
Lead sponsor
University of Arkansas
Other
Eligibility
50 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Little Rock, Arkansas
Completed Not applicable Interventional Accepts healthy volunteers

Long-Duration Ultrasound for Knee Osteoarthritis

NCT03800927
Conditions
Osteo Arthritis Knee
Interventions
Long duration ultrasound
Device
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Stamford, Connecticut • Dryden, New York
Conditions
Osteoarthritis, Knee, Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
Interventions
4 mL injection of Ampion, 4 mL Injection of Placebo
Biological · Drug
Lead sponsor
Ampio Pharmaceuticals. Inc.
Industry
Eligibility
40 Years to 85 Years
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
13
States / cities
Birmingham, Alabama • Encinitas, California • Fullerton, California + 10 more
Conditions
Knee Osteoarthritis
Interventions
Whole body vibration, Local muscle vibration
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Conditions
Osteoarthritis, Pain
Interventions
Placebo Gel, OLT1177 Gel
Drug
Lead sponsor
Olatec Therapeutics, Inc.
Industry
Eligibility
45 Years to 80 Years
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
13
States / cities
Birmingham, Alabama • Milford, Connecticut • DeLand, Florida + 10 more
Conditions
Osteoarthritis, Knee
Interventions
BMA cell therapy injection
Procedure
Lead sponsor
Advanced Orthopaedic Specialists
Other
Eligibility
18 Years to 79 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Fayetteville, Arkansas
Completed Phase 2Phase 3 Interventional Results available

AMZ001 for the Treatment of Knee Osteoarthritis Symptoms

NCT03691844
Conditions
Osteoarthritis, Knee
Interventions
AMZ001, Placebo, Comparator
Drug
Lead sponsor
Amzell
Industry
Eligibility
40 Years to 85 Years
Enrollment
444 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Milford, Connecticut • The Villages, Florida • Williamsville, New York
Completed Phase 1 Interventional Accepts healthy volunteers

Impact of Mesenchymal Stem Cells in Knee Osteoarthritis

NCT03477942
Conditions
Musculoskeletal Pain, Knee Osteoarthritis, Cartilage Injury, Cartilage Degeneration
Interventions
Autologous Mesenchymal Stem Cells
Biological
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Conditions
Osteoarthritis, Knee, Knee Osteoarthritis
Interventions
ConforMIS iUni, iDuo, or iTotal (CR)
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
950 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boynton Beach, Florida
Conditions
Osteoarthritis of the Knee
Interventions
Bone morphogenetic protein 7, Placebo
Drug
Lead sponsor
Stryker Biotech
Industry
Eligibility
40 Years and older
Enrollment
355 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
25
States / cities
Glendale, Arizona • Tucson, Arizona • Palo Alto, California + 20 more
Conditions
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Interventions
LNA043, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
50 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Phoenix, Arizona
Conditions
Joint Disease
Interventions
Not listed
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2023
U.S. locations
1
States / cities
Rochester Hills, Michigan
Conditions
Osteoarthritis
Interventions
Myalgesin™ (celery seed extract, Boswellia serrata extract, Phellodendron extract)
Dietary Supplement
Lead sponsor
ProThera, Inc.
Industry
Eligibility
50 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Albany, New York
Conditions
Osteoarthritis of the Knee
Interventions
Diclofenac Sodium Gel, Placebo
Drug
Lead sponsor
Novartis
Industry
Eligibility
35 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
64
States / cities
Mobile, Alabama • Tallassee, Alabama • Chandler, Arizona + 59 more
Conditions
Knee Osteoarthritis
Interventions
Lorecivivint, Placebo
Drug
Lead sponsor
Biosplice Therapeutics, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
501 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
99
States / cities
Birmingham, Alabama • Peoria, Arizona • Phoenix, Arizona + 85 more
Conditions
Knee Osteoarthritis
Interventions
Mindfulness-Based Stress Reduction, Health Enhancement Program
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
50 Years to 80 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Davis, California