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ClinicalTrials.gov public records Last synced Sep 2, 2026, 2:14 AM EDT

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Showing 1–24 of 49 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: LIFU Clear all
Recruiting Not applicable Interventional

Low-Intensity Focused Ultrasound (LIFU) Neuromodulation

NCT05997030
View directory record Official record
Conditions
Alzheimer Disease
Interventions
low intensity focused ultrasound (LIFU)
Device
Lead sponsor
Ali Rezai
Other
Eligibility
45 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 2, 2026, 2:14 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Low-intensity Focused Ultrasound and Autonomic Response

NCT05834829
View directory record Official record
Conditions
Autonomic Dysfunction
Interventions
Low-intensity focused ultrasound neuromodulation, Sham Low-intensity focused ultrasound
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Low-Intensity Focused Ultrasound for Cocaine Use Disorder

NCT05857852
View directory record Official record
Conditions
Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
Interventions
Low-Intensity Focused Ultrasound, Sham LIFU device
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Not yet recruiting Not applicable Interventional

LIFU Effects & Outcomes: Mechanisms Evaluating Striatal Systems Imaging (LEO MESSI)

NCT07710989
View directory record Official record
Conditions
Schizophrenia, Auditory Hallucinations
Interventions
LIFU
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 64 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Completed Not applicable Interventional

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD)

NCT06612788
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Exablate Model 4000 Type 2.0/2.1
Device
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 60 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Sep 2, 2026, 2:14 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans

NCT07508722
View directory record Official record
Conditions
Healthy Volunteers, no Condition, Basic Science
Interventions
Transcranial Focused Ultrasound Stimulation, Electroencephalography, Magnetic Resonance Imaging
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
21 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

tFUS Imaging & LIFU

NCT07222865
View directory record Official record
Conditions
Brain Imaging
Interventions
Feasibility of imaging using tFUS
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Sep 2, 2026, 2:14 AM EDT
Recruiting Not applicable Interventional

Ultrasound Neuromodulation in Essential Tremor

NCT06610877
View directory record Official record
Conditions
Essential Tremor, Neuromodulation
Interventions
Focused Ultrasound Neuromodulation - Sham Control, Focused ultrasound neuromodulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Recruiting Not applicable Interventional

Low Intensity Focused Ultrasound for Chronic Pain: High Resolution Targeting of The Human Insula

NCT06906211
View directory record Official record
Conditions
Chronic Back Pain, Chronic Pain (Back / Neck)
Interventions
low intensity focused ultrasound (LIFU)
Device
Lead sponsor
Washington D.C. Veterans Affairs Medical Center
Federal
Eligibility
21 Years to 75 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Enrolling by invitation Not applicable Interventional

Low-Intensity Focused Ultrasound Neuromodulation for Epilepsy

NCT07353918
View directory record Official record
Conditions
Epilepsy (Treatment Refractory), Epilepsy Comorbidities
Interventions
Low-intensity Focused Ultrasound, Sham
Device
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Recruiting Not applicable Interventional

LIFU Mechanisms for PTSD in Healthcare Workers

NCT07164105
View directory record Official record
Conditions
PTSD and Trauma-related Symptoms
Interventions
Low intensity focused ultrasound, Sham modulation
Device
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Recruiting Not applicable Interventional

Low Intensity Focused Ultrasound for Tobacco Use Disorder: High Resolution Targeting of the Human Insula

NCT06405074
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
low intensity focused ultrasound (LIFU)
Device
Lead sponsor
Washington D.C. Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 19, 2024 · Synced Sep 2, 2026, 2:14 AM EDT
Completed Not applicable Interventional

Low Intensity Focused Ultrasound: a New Paradigm for Depression and Anxiety

NCT05147142
View directory record Official record
Conditions
Depression
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
Ocean State Research Institute, Inc.
Other
Eligibility
22 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Investigation of Low-intensity Focused Ultrasound Pressure

NCT06343883
View directory record Official record
Conditions
Somatic Pain
Interventions
low-intensity focused ultrasound - low pressure, low-intensity focused ultrasound - medium pressure, low-intensity focused ultrasound - high pressure
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Enrolling by invitation Not applicable Interventional

Mapping LIFU Responses Using iEEG Recordings

NCT07518927
View directory record Official record
Conditions
Low Intensity Focussed Ultrasound, Electrodes, Implanted
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals

NCT05303415
View directory record Official record
Conditions
Pain
Interventions
Neuromodulation with low-intensity focused ultrasound
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Not yet recruiting Phase 1 Interventional

Low Intensity Focused Ultrasound in ASD

NCT07225322
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
Active LIFU
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
13 Years to 25 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Recruiting Phase 2 Interventional

SONATA LIFU for OCD

NCT07728994
View directory record Official record
Conditions
Obsessive Compulsive Disorder
Interventions
Low Intensity Focused Ultrasound, Sham (No Treatment)
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
22 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Recruiting Not applicable Interventional

Low-Intensity Focused Ultrasound and the Complex Patient

NCT06297200
View directory record Official record
Conditions
Opioid Use Disorder, Chronic Pain, Anxiety Disorder
Interventions
Low-Intensity Focused Ultrasound, Low-Intensity Focused Ultrasound - sham
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 2, 2025 · Synced Sep 2, 2026, 2:14 AM EDT
Recruiting Not applicable Interventional

OCD LIFU Target Engagement

NCT07558148
View directory record Official record
Conditions
Obsessive Compulsive Disorder (OCD)
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Suspended Not applicable Interventional

Decision Making in Chronic Pain and Alcohol Use Disorder

NCT05901610
View directory record Official record
Conditions
Alcohol Use Disorder, Chronic Pain
Interventions
Episodic Future Thinking, Control Episodic Thinking, Low-intensity Focused Ultrasound, Sham Low-intensity Focused Ultrasound
Behavioral · Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Recruiting Not applicable Interventional

LIFU for Treatment for Refractory Opioid Use Disorder

NCT06218706
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Low Intensity Focussed Ultrasound
Device
Lead sponsor
Ali Rezai
Other
Eligibility
22 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 2, 2026, 2:14 AM EDT
Active, not recruiting Not applicable Interventional

Low Intensity Focused Ultrasound for Binge Eating Disorder

NCT06485687
View directory record Official record
Conditions
Binge-Eating Disorder
Interventions
LIFU Neuromodulation
Device
Lead sponsor
Ali Rezai
Other
Eligibility
22 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Sep 2, 2026, 2:14 AM EDT
Active, not recruiting Not applicable Interventional

Imaging-Guided Low Intensity Focused Ultrasound (LIFU)

NCT05467085
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
BX Pulsar 1002
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
3
States / cities
Boston, Massachusetts • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 17, 2025 · Synced Sep 2, 2026, 2:14 AM EDT