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ClinicalTrials.gov public records Last synced Oct 25, 2026, 12:34 AM EDT

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Showing 1–24 of 42 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Mitral Valve Repair Surgery Clear all
Active, not recruiting No phase listed Observational

Long Term Follow Up for CTSN Mitral Valve Repair Studies

NCT03066050
View directory record Official record
Conditions
Mitral Valve Insufficiency, Coronary Artery Disease
Interventions
MV Repair, MV Replacement, CABG
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
368 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
16
States / cities
Los Angeles, California • Atlanta, Georgia • Baltimore, Maryland + 13 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Oct 25, 2026, 12:34 AM EDT
Not listed No phase listed Observational

MRI as a Predictor of Outcomes in Patients Undergoing Mitral Valve Surgery

NCT03012178
View directory record Official record
Conditions
Mitral Valve Insufficiency
Interventions
Mitral valve surgery
Procedure
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 11, 2018 · Synced Oct 25, 2026, 12:34 AM EDT
Active, not recruiting Not applicable Interventional

Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)

NCT05051033
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
Mitral valve repair, Transcatheter edge-to-edge repair
Procedure · Device
Lead sponsor
Annetine Gelijns
Other
Eligibility
60 Years and older
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2034
U.S. locations
29
States / cities
Los Angeles, California • San Francisco, California • Stanford, California + 19 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 25, 2026, 12:34 AM EDT
Not listed No phase listed Observational

Primary Mitral Regurgitation Repair

NCT04067635
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Prolapse, Chronic Mitral Disease, Mitral Regurgitation, Mitral Valve Disease, Degenerative Mitral Valve Disease, Myxomatous Mitral Valve Degeneration, Ventricular Remodeling
Interventions
Not listed
Lead sponsor
Eric Y. Yang, MD PhD
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 25, 2026, 12:34 AM EDT
Completed Not applicable Interventional Results available

ABLATE Post Approval Study - Synergy Ablation Lesions for Non-Paroxysmal Atrial Fibrillation

NCT01694563
View directory record Official record
Conditions
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Interventions
Synergy Ablation System
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years and older
Enrollment
365 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
49
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Los Angeles, California + 41 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2019 · Synced Oct 25, 2026, 12:34 AM EDT
Completed No phase listed Observational

Quality of Life After Open Heart Surgery in Older Patients

NCT00248898
View directory record Official record
Conditions
Open Heart Surgery Patients
Interventions
Cardiac Surgery
Procedure
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
90 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 20, 2017 · Synced Oct 25, 2026, 12:34 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biomarkers in Aortic Stenosis - B.A.S.S.

NCT01334801
View directory record Official record
Conditions
Aortic Stenosis, Disorder of Prosthetic Cardiac Valve, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Hypertrophic Cardiomyopathy, Tricuspid Valve Insufficiency
Interventions
Blood Draw
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
21 Years and older
Enrollment
378 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Oct 25, 2026, 12:34 AM EDT
Completed Not applicable Interventional

The CorCinch - Functional Mitral Valve Regurgitation (FMR) Study

NCT02806570
View directory record Official record
Conditions
Heart Failure, Mitral Valve Insufficiency, Cardiomyopathies
Interventions
Mitral valve repair
Device
Lead sponsor
Ancora Heart, Inc.
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
16
States / cities
Atlanta, Georgia • Louisville, Kentucky • Minneapolis, Minnesota + 12 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Oct 25, 2026, 12:34 AM EDT
Terminated Phase 3 Interventional Results available

Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure

NCT00608140
View directory record Official record
Conditions
Mitral Valve Insufficiency, Heart Failure
Interventions
Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT)
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
8
States / cities
Atlanta, Georgia • Boston, Massachusetts • Minneapolis, Minnesota + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Oct 25, 2026, 12:34 AM EDT
Completed Not applicable Interventional Results available

Evaluating the Benefit of Concurrent Tricuspid Valve Repair During Mitral Surgery

NCT02675244
View directory record Official record
Conditions
Mild Tricuspid Regurgitation, Moderate Tricuspid Regurgitation, Tricuspid Regurgitation
Interventions
TV Annuloplasty, MVS
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
401 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
24
States / cities
Los Angeles, California • Stanford, California • New Haven, Connecticut + 20 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2024 · Synced Oct 25, 2026, 12:34 AM EDT
Active, not recruiting Not applicable Interventional

PRIMARY Ancillary Substudy

NCT07103733
View directory record Official record
Conditions
Mitral Valve Prolapse, Left Ventricular Fibrosis, Ventricular Arrhythmias
Interventions
Cardiac Magnetic Resonance Imaging, ZioPatch Monitoring, Myocardial Tissue Biopsy
Procedure · Device
Lead sponsor
Annetine Gelijns
Other
Eligibility
60 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
16
States / cities
Los Angeles, California • San Francisco, California • Stanford, California + 11 more
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 25, 2026, 12:34 AM EDT
Not listed Not applicable Interventional Results available

Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) and COAPT CAS

NCT01626079
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Regurgitation, Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects, Heart Failure
Interventions
MitraClip System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
776 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2024
U.S. locations
81
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 65 more
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Oct 25, 2026, 12:34 AM EDT
Recruiting No phase listed Observational

Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation

NCT07605715
View directory record Official record
Conditions
Degenerative Mitral Valve Disease
Interventions
Not listed
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Oct 25, 2026, 12:34 AM EDT
Recruiting No phase listed Observational

CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

NCT04688190
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Disease, Mitral Annular Calcification
Interventions
Not listed
Lead sponsor
Universitätsklinikum Hamburg-Eppendorf
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
9
States / cities
Tucson, Arizona • Los Angeles, California • Tampa, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 25, 2026, 12:34 AM EDT
Completed Not applicable Interventional Results available

Pivotal Study of a Percutaneous Mitral Valve Repair System

NCT00209274
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation, Mitral Insufficiency
Interventions
Percutaneous mitral valve repair using MitraClip implant, Mitral valve repair or replacement surgery
Device · Procedure
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
279 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 7, 2018 · Synced Oct 25, 2026, 12:34 AM EDT
Completed Phase 2 Interventional Results available

Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery

NCT00903370
View directory record Official record
Conditions
Atrial Fibrillation, Mitral Valve Insufficiency, Mitral Valve Stenosis
Interventions
MVS, Ablation
Procedure · Device
Lead sponsor
Annetine Gelijns
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
18
States / cities
New Haven, Connecticut • Newark, Delaware • Atlanta, Georgia + 14 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2017 · Synced Oct 25, 2026, 12:34 AM EDT
Terminated Not applicable Interventional Results available

Cardiovalve Transfemoral Mitral Valve System

NCT03813524
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Cardiovalve Transfemoral Mitral Valve
Device
Lead sponsor
Cardiovalve Ltd.
Industry
Eligibility
18 Years to 84 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Atlanta, Georgia • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 25, 2026, 12:34 AM EDT
Not listed Phase 1Phase 2 Interventional

Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle

NCT03079401
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome, Atrioventricular Canal
Interventions
MPC; rexlemestrocel-L
Biological
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 5 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 21, 2023 · Synced Oct 25, 2026, 12:34 AM EDT
Completed No phase listed Observational

Testing Automated Echocardiography

NCT04943965
View directory record Official record
Conditions
This Study is Being Conducted to Collect Echocardiographic Data to Test the Lumify Ultrasound With Hemodynamic Automation Device
Interventions
Ultrasound imaging
Diagnostic Test
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 19, 2023 · Synced Oct 25, 2026, 12:34 AM EDT
Completed Not applicable Interventional Results available

The CLASP Study Edwards PASCAL TrAnScatheter Mitral Valve RePair System Study

NCT03170349
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
Mitral Valve Repair
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
8
States / cities
Los Angeles, California • Aurora, Colorado • Evanston, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 25, 2026, 12:34 AM EDT
Recruiting Not applicable Interventional

Use of Force Feedback Instruments With the da Vinci Surgical System, Model IS5000 for Mitral Valve Repair

NCT07655505
View directory record Official record
Conditions
Mitral Regurgitation (MR)
Interventions
Mitral Valve Repair including the use of Force Feedback instruments
Device
Lead sponsor
Intuitive Surgical
Industry
Eligibility
22 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Atlanta, Georgia • New York, New York • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 25, 2026, 12:34 AM EDT
Not listed Not applicable Interventional

Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery

NCT04770961
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Insufficiency, Mitral Valve Prolapse
Interventions
Erector spinae plane catheter with 0.5% Ropivacaine, Erector spinae plane catheter with saline
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Oct 25, 2026, 12:34 AM EDT
Recruiting No phase listed Observational

Patient-Centered Approach for Treatment Decisions in Mitral Valve Prolapse

NCT06738537
View directory record Official record
Conditions
Mitral Valve Prolapse
Interventions
Focus Groups/Quantitative Survey for Patients, Focus Group/Quantitative Survey for HCPs, Qualitative Focus Group
Other
Lead sponsor
Northwell Health
Other
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
5
States / cities
Los Angeles, California • Kansas City, Missouri • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Oct 25, 2026, 12:34 AM EDT
Not listed Phase 4 Interventional

Pilot Study of Lovaza (Omega 3 Fatty Acids) to Improve Cardiac Antioxidant/Anti-inflammatory Profile Before Cardiac Surgery

NCT01046604
View directory record Official record
Conditions
Mitral Valve Regurgitation, Left Atrium Dilatation and Hypertrophy, Mitochondrial Dysfunction in the Heart, Cardiomyocyte Apoptosis, Cardiac Inflammation
Interventions
Lovaza group
Drug
Lead sponsor
East Carolina University
Other
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 10, 2013 · Synced Oct 25, 2026, 12:34 AM EDT