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Conditions: Iron Deficiency Anemia, Pregnancy
Interventions: Ferric derisomaltose, Ferrous sulfate; Drug
Lead sponsor: Women and Infants Hospital of Rhode Island; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 8
States / cities: Birmingham, Alabama • Miami, Florida • Ann Arbor, Michigan + 4 more

Conditions: Post Operative Pain
Interventions: 0.25% bupivicaine will be injected at the study port site prior to incision, Saline will be injected at the study port site prior to incision, Saline will be in injected into the port site prior to closure, 0.25% bupivicaine will be injected into the port site prior to closure; Drug
Lead sponsor: Stony Brook University; Other
Eligibility: 21 Years and older · Female only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Total Shoulder Arthroplasty
Interventions: bupivacaine., Saline; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 85 Years
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Pregnancy
Interventions: Normal Saline Infusion, Capped Epidural; Drug · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older · Female only
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Hysterectomy, Cystoscopy
Interventions: water as bladder distending media, intravenous dye, No intervention; Diagnostic Test
Lead sponsor: WellSpan Health; Other
Eligibility: 18 Years to 90 Years · Female only
Enrollment: 276 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: York, Pennsylvania

Conditions: Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
Interventions: Minimal mechanical ventilation management, Routine mechanical ventilation management, Dexamethasone, Placebo; Procedure · Drug
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: 5 Minutes to 10 Days
Enrollment: 220 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1998 – 2002
U.S. locations: 13
States / cities: Birmingham, Alabama • Palo Alto, California • New Haven, Connecticut + 10 more

Conditions: Nausea, Postoperative
Interventions: QUEASEEase aromatherapy quick tab, Placebo product; Other
Lead sponsor: Inova Health Care Services; Other
Eligibility: 18 Years to 99 Years
Enrollment: 113 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Thyroid Eye Disease, Graves' Orbitopathy
Interventions: Teprotumumab, Placebo; Biological · Other
Lead sponsor: Amgen; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 9
States / cities: Beverly Hills, California • Los Angeles, California • Coral Gables, Florida + 6 more

Conditions: Asthma
Interventions: Nebulized magnesium sulfate; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 7 Years to 18 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Sedation, Conscious
Interventions: Midazolam, xylocaine, saline placebo; Drug
Lead sponsor: Bassett Healthcare; Other
Eligibility: 18 Months to 7 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Cooperstown, New York

Conditions: Ulcerative Colitis, Inflammatory Bowel Diseases
Interventions: Fecal Microbiota Transplantation, Psyllium Husk Powder; Drug · Dietary Supplement
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 89 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Status Epilepticus
Interventions: Intramuscular route of active treatment, Intravenous route of active treatment; Drug
Lead sponsor: Robert Silbergleit; Other
Eligibility: Not listed
Enrollment: 1,023 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 17
States / cities: Tucson, Arizona • Palo Alto, California • San Francisco, California + 12 more

Conditions: Infant, Premature, Erythropoietin, Brain Injury, Intraventricular Hemorrhage, Periventricular Leukomalacia, Neurodevelopmental Outcomes, Randomized Clinical Trial
Interventions: Erythropoietin, Saline placebo; Drug
Lead sponsor: Atlantic Health System; Other
Eligibility: Up to 24 Hours
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Morristown, New Jersey

Conditions: Tinnitus, Noise Induced
Interventions: Etanercept, Saline; Biological · Other
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years and older
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 4
States / cities: Celebration, Florida • Coral Gables, Florida • Detroit, Michigan + 1 more

Conditions: Moderate-to-severely Painful Ankle Surgery
Interventions: Popliteal nerve block including liposomal bupivacaine, Adductor canal nerve block including liposomal bupivacaine, Continuous popliteal nerve block with normal saline, Popliteal nerve block with exclusively unencapsulated bupivacaine, Adductor canal nerve block with exclusively unencapsulated bupivacaine, Continuous popliteal nerve block with unencapsulated bupivacaine; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Pneumococcal Disease, COVID-19, SARS-CoV-2 Infection
Interventions: 20-valent pneumococcal conjugate vaccine (20vPnC), BNT162b2, Saline; Biological · Other
Lead sponsor: Pfizer; Industry
Eligibility: 65 Years and older
Enrollment: 570 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 27
States / cities: Anaheim, California • Walnut Creek, California • Coral Gables, Florida + 21 more

Conditions: Familial Hypoalphalipoproteinemia
Interventions: CER-001, Placebo; Drug
Lead sponsor: Cerenis Therapeutics, SA; Industry
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Opioid-induced Constipation
Interventions: Methylnaltrexone Bromide, Placebo-Normal Saline; Drug
Lead sponsor: St. John Health System, Michigan; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Southfield, Michigan

Conditions: Postoperative Pain
Interventions: TAP-C, TAP-S; Device · Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Osteoporosis, Spinal Cord Injury
Interventions: Denosumab, Placebo (identical Denosumab volume of normal saline); Drug
Lead sponsor: James J. Peters Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: West Orange, New Jersey • The Bronx, New York

Conditions: Cystic Fibrosis
Interventions: 7% Hypertonic Saline (HS), 0.9% Isotonic Saline (IS); Drug
Lead sponsor: CF Therapeutics Development Network Coordinating Center; Network
Eligibility: 4 Months to 59 Months
Enrollment: 321 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 28
States / cities: Birmingham, Alabama • Phoenix, Arizona • Palo Alto, California + 24 more

Conditions: Hip Fractures, Anesthesia, Spinal, Anesthesia, General, Neuromuscular Blockade
Interventions: Rocuronium, Sugammadex, Normal saline; Drug
Lead sponsor: Loyola University; Other
Eligibility: 55 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Maywood, Illinois

Conditions: Candidemia, Mycoses, Fungal Infection, Fungemia, Invasive Candidiasis, Pneumocystis, Mold Infection, Invasive Fungal Disease, Prophylaxis of Invasive Fungal Infections, Aspergillus
Interventions: Rezafungin for Injection, Posaconazole, Fluconazole, Trimethoprim-sulfamethoxazole (TMP/SMX), Intravenous Placebo, Oral Placebo; Drug
Lead sponsor: Mundipharma Research Limited; Industry
Eligibility: 18 Years and older
Enrollment: 602 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 18
States / cities: Birmingham, Alabama • Los Angeles, California • Stanford, California + 13 more

Conditions: Pregnancy Termination in Second Trimester
Interventions: Nitrous Oxide, IV Saline; Drug
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years and older · Female only
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 2
States / cities: Denver, Colorado • Albuquerque, New Mexico

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Intravenous Versus Oral Iron for Treating Iron-Deficiency Anemia in Pregnancy

Study to Compare Reduction in Pain After Surgery With and Without Local Anesthesia During Laparoscopy

Addition of a Pectoserratus Block to Interscalene Block in Patients Undergoing Total Shoulder Replacement

Efficacy of Labor Epidurals for Postpartum Tubal Ligation

The Use of Dye-less Cystoscopy in Assessing Urinary Tract Integrity During Hysterectomy

Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)

Effects of Aromatherapy on Nausea Levels

Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study

Nebulized Magnesium Sulfate in Children With Moderate to Severe Asthma Exacerbation

Intranasal Midazolam in Children as a Pre-Operative Sedative

Examining the Efficacy of Fecal Microbiota Transplantation (FMT) and Dietary Fiber in Patients With Ulcerative Colitis

Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications

High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study

TNF-α Treatment of Blast-Induced Tinnitus

Liposomal Bupivacaine Versus Continuous Peripheral Nerve Blocks for Analgesia Following Ankle Surgery

Safety and Immunogenicity Study of 20vPnC When Coadministered With a Booster Dose of BNT162b2

CER-001 Therapy as a Novel Approach to Treat Genetic Orphan Diseases

Methylnaltrexone for Treatment of Opiate-Induced Constipation in the Intensive Care Unit

Single-shot TAP Block vs Continuous TAP Block

Denosumab Administration After Spinal Cord Injury

Infant Study of Inhaled Saline in Cystic Fibrosis

GA/Spinal vs. GA/Spinal/NMB for Operative Repair of Hip Fracture

Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation

Nitrous Oxide Versus Intravenous Sedation for Anesthesia