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ClinicalTrials.gov public records Last synced Nov 12, 2026, 7:45 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 98 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Pressure support ventilation Clear all

Conditions: Respiratory Failure
Interventions: Neurally-Adusted Ventilatory Assist (NAVA), Biphasic Positive Airway Pressure Support (BiPAP); Device
Lead sponsor: Children's Hospitals and Clinics of Minnesota; Other
Eligibility: Up to 12 Months
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Brain Death, Respiration, Artificial
Interventions: Hope inVent; Device
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 1 Year to 100 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Inadequate; Pulmonary Ventilation, Newborn, Infant, Very Low Birth Weight
Interventions: Nasal NIV-NAVA; Device
Lead sponsor: Tarah T Colaizy; Other
Eligibility: 7 Days to 1 Year
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 2
States / cities: Iowa City, Iowa

Conditions: COVID-19
Interventions: Respiratory supports; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 2,300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Spinal Cord Injury
Interventions: Non-invasive ventilation(NIV), Sham Non-invasive ventilation(NIV), Functional Electrical Stimulation Row Training (FESRT); Device · Other
Lead sponsor: Spaulding Rehabilitation Hospital; Other
Eligibility: 18 Years to 70 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
Interventions: Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL), Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS), Early Cohort corticosteroid dose, Extended Cohort corticosteroid dose, Usual care without routine corticosteroids, Usual care without extending corticosteroids, Usual care with fludrocortisone, Usual care without fludrocortisone, Drug 4 mL:, Drug 40 mg:, PEEP-20, PEEP-AOP, PEEP-10, VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation, Electrical impedance tomography (EIT), no treatment / intervention arm is involved., Usual care, Early Routine IMT; Other · Drug
Lead sponsor: University Health Network, Toronto; Other
Eligibility: 18 Years and older
Enrollment: 6,250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 27
States / cities: Tucson, Arizona • Los Angeles, California • San Diego, California + 20 more

Conditions: Acute Hypoxemic Respiratory Failure
Interventions: Mechanical ventilation; Device
Lead sponsor: Hospital Universitario de Gran Canaria Doctor Negrín; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: X-linked Myotubular Myopathy
Interventions: History and physical, Tidal breathing, Maximal respiratory pressures, Peak cough flow, Pediatric Evaluation of Disability Inventory, PedsQL Multidimensional Fatigue Scale, Review of ventilation requirements; Other
Lead sponsor: University of Florida; Other
Eligibility: Up to 14 Years · Male only
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Ventilation
Interventions: Spontaneous ventilation, Pressure support ventilation, Pressure control ventilation; Other · Device
Lead sponsor: Wake Forest University; Other
Eligibility: 1 Month to 11 Months
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Obstructive Sleep Apnea, Hypertonia, Muscle, Nasal Airway Obstruction, Tolerance, Trisomy 21, Down Syndrome
Interventions: Self-Supporting Nasopharyngeal Airway (ssNPA); Device
Lead sponsor: University of Michigan; Other
Eligibility: 3 Years to 21 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Sepsis
Interventions: Bilateral phrenic nerve stimulation and measurement of transdiaphragmatic pressure, Midazolam, Volitional Measurement of Maximal Inspiratory Pressure (MIP), Inspiratory Muscle Strength Training (IMST), SHAM Inspiratory Muscle Strength Training (IMST), Diaphragm thickness measurement, Blood and Urine samples; Procedure · Drug · Device + 1 more
Lead sponsor: University of Florida; Other
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage, Stroke, Cerebrovascular Disease
Interventions: Reversal of Oral anticoagulation within 30 minutes, Early intensive blood pressure lowering, Treatment of pyrexia, Hyperglycemia treatment, Do-not-resuscitate (DNR) or withdrawal of care, Referral to Intensive Care, Referral to Neurosurgery, Repeat brain imaging, Standard care; Other · Diagnostic Test
Lead sponsor: Region Skane; Other
Eligibility: 18 Years and older
Enrollment: 3,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Insomnia, Sleep-Disordered Breathing
Interventions: AirCurve 10 ASV; Device
Lead sponsor: ResMed; Industry
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Respiratory Failure
Interventions: Neurally Adjusted Ventilatory Assist (NAVA); Device
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 1 Month to 18 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: COPD, Dyspnea
Interventions: Vitabreath Device, Pursed Lip Breathing; Device · Other
Lead sponsor: Philips Respironics; Industry
Eligibility: 40 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 2
States / cities: Youngstown, Ohio • Jefferson Hills, Pennsylvania

Conditions: Cardiomyopathy, Cardiovascular Disease, Heart Disease
Interventions: Respiratory Depression Monitoring with End Tidal Carbon Dioxide Nasal Cannula (ETCO2- NC), Standard Non-invasive Respiratory Depression Monitoring; Device · Other
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training, Exercise Intolerance, Dietary Supplement, Nitrate Supplementation, Inspiratory Muscle Training
Interventions: Respiratory Muscle Training (RMT), Sham Respiratory Muscle Training, Dietary Supplement: Beetroot Juice Concentrate, placebo beverage; Device · Dietary Supplement
Lead sponsor: Embry-Riddle Aeronautical University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Daytona Beach, Florida

Conditions: COPD
Interventions: Home noninvasive nocturnal ventilation with Breas VIVO 50 home ventilator or newer model as available, Breas Medical., Arterial blood gas (ABG) and serum bicarbonate level, Overnight home oximetry and transcutaneous CO2 monitoring; Device · Diagnostic Test
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Respiration, Artificial
Interventions: Proportional Assist Ventilation, Pressure Support Ventilation; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Premature Infant Disease, Respiratory Insufficiency
Interventions: non-synchronized NIMV, Synchronized NIMV; Other
Lead sponsor: University of Miami; Other
Eligibility: Not listed
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Obesity, Morbid, Ventilator-Induced Lung Injury, Respiratory Failure
Interventions: Esophageal balloon, Intervention Spontaneous Breathing Trial (SBT) and Extubation, Control Spontaneous Breathing Trial and Extubation, Intervention Weaning after Tracheostomy, Control Weaning after Tracheostomy; Device · Procedure
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 2
States / cities: Chapel Hill, North Carolina • Greenville, North Carolina

Conditions: Sleep Apnea, Opioid Use, Sleep Disordered Breathing
Interventions: Hyperoxia, Acetazolamide; Other · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 89 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2027
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: PTSD, Signs and Symptoms, Respiratory
Interventions: Relaxation Response Resiliency Program (3RP), Health Enhancement Program (HEP); Behavioral
Lead sponsor: Stony Brook University; Other
Eligibility: 18 Years and older
Enrollment: 157 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Dyspnea, Hypercapnic Acidosis
Interventions: High Velocity Nasal Insufflation (HVNI), Noninvasive Positive Pressure Ventilation (NIPPV); Device
Lead sponsor: Vapotherm, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 68 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 7
States / cities: Los Angeles, California • Oxnard, California • Washington D.C., District of Columbia + 4 more

Search by objective public record fields.

NAVA Versus BiPAP Non-Invasive Respiratory Support in Infants Following Congenital Heart Surgery

Miniature In-line Respirator

Nasal Noninvasive NAVA in the Very Low Birth Weight Infant

Respiratory Supports and COVID-19 Mortality

Acute Effect of Ventilatory Support During Exercise in Spinal Cord Injury

Platform of Randomized Adaptive Clinical Trials in Critical Illness

Assessment of PaO2/FiO2 Ratio Pre and POst INTubation

Respiratory Muscle Function in Untreated X-Linked Myotubular Myopathy (XLMTM)

A Comparison of Different Ventilation Strategies in Infants Using the PLMA™

Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

Project 4A: Inspiratory Muscle Training and Diaphragm Strength

International Care Bundle Evaluation in Cerebral Hemorrhage Research

CPAP vs ASV for Insomnia

Regional Distribution Differences Between Neurally Adjusted Ventilatory Assist and Pressure Support Ventilation

Vitabreath Pilot in Chronic Obstructive Pulmonary Disease (COPD) Patients

Employing End Tidal Capnography in Continuous Flow Ventricular Assist Device Patients

Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude

Sleep Ventilation for Patients With Advanced Hypercapnic COPD

Proportional Assist Ventilation vs Pressure Support Ventilation

Flow-synchronized Nasal IMV in Preterm Infants

Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon

Sleep Disordered Breathing With Opioid Use

Stress Management Program for World Trade Center (WTC) Responders

Clinical Stabilization of Hypercapnia: NIPPV v HVNI