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ClinicalTrials.gov public records Last synced Sep 17, 2026, 1:04 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Primary closure Clear all
Active, not recruiting Not applicable Interventional Results available

Fetoscopic NEOX Cord 1K® Spina Bifida Repair

NCT04243889
View directory record Official record
Conditions
Spina Bifida, Myelomeningocele, Myeloschisis
Interventions
NEOX Cord 1K
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 17, 2026, 1:04 PM EDT
Not listed Not applicable Interventional

Use of Hypertonic Saline After Damage Control Laparotomy to Improve Early Primary Fascial Closure

NCT02297659
View directory record Official record
Conditions
Open Abdomen After Damage Control Laparotomy
Interventions
Primary Fascial Closure, wound vac dressing application
Procedure · Device
Lead sponsor
San Antonio Military Medical Center
Federal
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Dec 14, 2015 · Synced Sep 17, 2026, 1:04 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Phase 1b/2 Study of BKM120 Plus Trastuzumab in Patients With HER2-positive Breast Cancer

NCT01132664
View directory record Official record
Conditions
Metastatic Breast Cancer, HER2+ Breast Cancer
Interventions
BKM120, Trastuzumab, Capecitabine
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
7
States / cities
Birmingham, Alabama • Fayetteville, Arkansas • Tampa, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 16, 2016 · Synced Sep 17, 2026, 1:04 PM EDT
Terminated Phase 2 Interventional

Utility of Restrata With Split-thickness Skin Graft to Reconstruct the Forearm Donor Site

NCT04880603
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
Restrata Graft, Standard of Care Skin Graft
Device · Procedure
Lead sponsor
Nebraska Methodist Health System
Other
Eligibility
19 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated May 12, 2022 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Not applicable Interventional

A Randomized Trial of Ostomy Closure Techniques

NCT01713452
View directory record Official record
Conditions
Wound Infection
Interventions
Purse string closure, Primary closure
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 31, 2019 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Not applicable Interventional Results available

Evaluating Advantages of Prevena After Hip and Knee Arthroplasty

NCT01854138
View directory record Official record
Conditions
Infection of Total Hip Joint Prosthesis
Interventions
Prevena Incision Management System
Device
Lead sponsor
ProMedica Health System
Other
Eligibility
18 Years to 85 Years
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 11, 2018 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Phase 2 Interventional

Phase IIA Double-Masked Randomized Sham-Controlled Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Subjects With Acute Primary Angle-Closure Glaucoma (APACG)

NCT01965106
View directory record Official record
Conditions
Glaucoma, Angle-closure, Primary, Acute
Interventions
QPI-1007 Injection, (including placebo)
Drug
Lead sponsor
Quark Pharmaceuticals
Industry
Eligibility
40 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
4
States / cities
Orange, California • Pasadena, California • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 6, 2017 · Synced Sep 17, 2026, 1:04 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Role of Topical Tranexamic Acid in Total Hip Arthroplasty

NCT01866943
View directory record Official record
Conditions
Post Operative Blood Loss
Interventions
Tranexamic Acid, Normal Saline Solution
Drug
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 80 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 12, 2018 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Not applicable Interventional Results available

DuraSeal Sealant Post Market Study

NCT00704340
View directory record Official record
Conditions
Elective Cranial Procedures With Dural Incision
Interventions
DuraSeal Dural Sealant System, Standard of Care
Device · Other
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
237 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 6, 2017 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Not applicable Interventional Results available

An Evaluation of Rigid Sternal Fixation in Supporting Bone Healing and Improving Postoperative Recovery

NCT01783483
View directory record Official record
Conditions
Coronary Artery Disease, Angina Pectoris, Cardiac Valve Disease
Interventions
SternaLock Blue closure system, Suture Wire
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
12
States / cities
Jacksonville, Florida • Orlando, Florida • Atlanta, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 7, 2017 · Synced Sep 17, 2026, 1:04 PM EDT
Completed No phase listed Observational

Microsurgical Breast Reconstruction & VTE

NCT03031457
View directory record Official record
Conditions
Breast Reconstruction, Venous Thromboembolism
Interventions
Duplex ultrasound
Diagnostic Test
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Not applicable Interventional Results available

A Trial of AI-Powered Text Message Outreach on Well-Child Visit Completion

NCT06698640
View directory record Official record
Conditions
Well Child Visit, Gaps in Care
Interventions
Automated SMS, Automated SMS + Conversational AI Scheduling Assistance, Traditional Passive Outreach
Behavioral · Other
Lead sponsor
Waymark
Industry
Eligibility
0 Years to 21 Years
Enrollment
2,821 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 17, 2026, 1:04 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Vacuum Assisted Closure for Cesarean Section

NCT02390401
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
Vacuum-assisted closure, Standard sterile dressing
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
166 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
4
States / cities
Lebanon, New Hampshire • Nashua, New Hampshire
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty

NCT02876055
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Single shot interscalene nerve block, Continuous interscalene nerve block, Local Infiltration Analgesia (LIA)
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Phase 4 Interventional Results available

Efficacy of Short Term Dabigatran Etexilate Followed by Aspirin Monotherapy After LAA (Left Atrial Appendage) Device Closure (the DEA-LAA Study).

NCT03539055
View directory record Official record
Conditions
Atrial Fibrillation, Device Related Thrombus, Left Atrial Appendage Thrombosis, Watchman LAA Closure Device
Interventions
Dabigatran Etexilate Oral Capsule
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 9, 2025 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Phase 3 Interventional Results available

Antimicrobial Barrier Dressing Versus Closed-incision Negative Pressure Therapy in the Obese Primary Total Joint Arthroplasty

NCT03345771
View directory record Official record
Conditions
Osteoarthritis
Interventions
Antimicrobial Barrier Dressing, Negative Pressure Wound Therapy (NPWT)
Combination Product · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 100 Years
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 21, 2022 · Synced Sep 17, 2026, 1:04 PM EDT
Recruiting Phase 4 Interventional

Knotless Implants As an Alternative for Capsular Closure in Primary Hip Arthroscopy: a Prospective, Multi-Center Study

NCT06500364
View directory record Official record
Conditions
Femoro Acetabular Impingement
Interventions
LoopLoc Arm, Control Arm
Device
Lead sponsor
American Hip Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Des Plaines, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 31, 2024 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Not applicable Interventional Results available

Investigational Device Evaluation of the WATCHMAN FLX™ LAA Closure Technology

NCT02702271
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
WATCHMAN FLX
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
458 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
29
States / cities
Birmingham, Alabama • Phoenix, Arizona • Jonesboro, Arkansas + 24 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2022 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Phase 2 Interventional Results available

Preventing Complications in Cleft Palate Repair With Antibiotics

NCT00760006
View directory record Official record
Conditions
Cleft Palates
Interventions
Unasyn, saline solution
Drug · Other
Lead sponsor
Joseph Losee
Other
Eligibility
3 Months to 18 Years
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 31, 2018 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Phase 2 Interventional

Efficacy Study of a Bioelectric Dressing Used With Negative Pressure Wound Therapy to Treat Diabetic and Pressure Ulcers

NCT01022216
View directory record Official record
Conditions
Wound Healing
Interventions
Procellera™ Wound Dressing with V.A.C.® Therapy, V.A.C.® Therapy
Device
Lead sponsor
Vomaris Innovations
Industry
Eligibility
18 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Feb 21, 2012 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Phase 2 Interventional

Comparison of Suturing and Packing of Drained Abscesses

NCT00465049
View directory record Official record
Conditions
Cutanoeus Abscesses
Interventions
PRIMARY CLOSRE, SECONDARY CLOSURE, SPONTANEOUS HALING
Other
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Oct 21, 2012 · Synced Sep 17, 2026, 1:04 PM EDT
Withdrawn Phase 4 Interventional

Adductor Canal Catheter vs Local Infiltration of Analgesia for Total Knee Arthroplasty

NCT02603900
View directory record Official record
Conditions
Acute Pain, Regional Anesthesia Morbidity
Interventions
ropivacaine, bupivacaine, Sham Adductor Canal Catheter, Adductor Canal Catheter
Drug · Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
40 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 14, 2021 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ridge Augmentation Without Primary Closure

NCT01901783
View directory record Official record
Conditions
Alveolar Ridge Augmentation
Interventions
With primary closure, Without primary closure
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 7, 2016 · Synced Sep 17, 2026, 1:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Perfusion Assessment of Wound Closure Techniques in Primary Total Knee Arthroplasty

NCT01924403
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Staple Closure, Vertical Mattress Closure, Running Subcuticular Closure
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 15, 2015 · Synced Sep 17, 2026, 1:04 PM EDT