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Conditions: Implantation, Embryo
Interventions: Leuprolide, Ganirelix; Drug
Lead sponsor: Kelly, Maureen, M.D.; Individual
Eligibility: 18 Years to 52 Years · Female only
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2006
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Breast Cancer
Interventions: Anastrozole, AZD0530 (saracatinib), Placebo; Drug
Lead sponsor: Joyce Marie Slingerland, MD; Other
Eligibility: 18 Years and older · Female only
Enrollment: 71 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2018
U.S. locations: 2
States / cities: Palo Alto, California • Miami, Florida

Conditions: Polycystic Ovarian Syndrome, Infertility
Interventions: Menotropin, Progesterone vaginal insert, Follitropin beta, Progesterone in oil, leuprolide acetate; Drug
Lead sponsor: Ferring Pharmaceuticals; Industry
Eligibility: 18 Years to 42 Years · Female only
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 6
States / cities: Littleton, Colorado • Clearwater, Florida • Chicago, Illinois + 3 more

Conditions: Major Depressive Disorder
Interventions: Pregnenolone 500 mg, Pregnenolone 800 mg, Placebo; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Endometrial Hyperplasia
Interventions: BAY865028, Medroxyprogesterone acetate; Combination Product · Drug
Lead sponsor: Bayer; Industry
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 22
States / cities: Phoenix, Arizona • Little Rock, Arkansas • West Hills, California + 19 more

Conditions: Secondary Amenorrhea
Interventions: Progesterone, Placebo; Drug
Lead sponsor: TherapeuticsMD; Industry
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 22
States / cities: Chandler, Arizona • Phoenix, Arizona • Tucson, Arizona + 19 more

Conditions: Long QT Syndrome
Interventions: Testosterone, Progesterone, Placebo, Ibutilide; Drug
Lead sponsor: Indiana University; Other
Eligibility: 65 Years and older · Male only
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Normal, PCOS
Interventions: oral micronized progesterone suspension, Placebo; Drug · Other
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years to 35 Years · Female only
Enrollment: 85 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2020
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Smoking, Smoking Cessation, Smoking Reduction
Interventions: Progesterone 200 MG Oral Capsule; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 171 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Premature Birth, Obstetric Labor, Premature
Interventions: Micronized progesterone suppository; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Traumatic Brain Injury, TBI
Interventions: Pregnenolone, Placebo; Drug
Lead sponsor: Christine Marx, MD; Other
Eligibility: 21 Years to 65 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Durham, North Carolina

Conditions: Preeclampsia, Hypertensive Disorder of Pregnancy
Interventions: Progesterone supplementation; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older · Female only
Enrollment: 642 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Orthostatic Intolerance
Interventions: Ganirelix acetate, 17β-Oestradiol, Progesterone; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 34 Years · Female only
Enrollment: 109 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Major Depressive Disorder, Anxiety Depression, HIV
Interventions: Placebo, Pregnenolone; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 85 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Ovulatory Dysfunction, Anovulation, Ovulation Induction
Interventions: clomiphene citrate; Drug
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Lower Back Pain
Interventions: Pregnenolone, Placebo; Drug
Lead sponsor: Durham VA Medical Center; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Primary Ovarian Insufficiency
Interventions: Hormone Replacement Therapy, Combined Oral Contraceptives; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 14 Years to 45 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Perimenopause-Related Depression
Interventions: Estradiol, ER Beta Agonist, Placebo, Provera; Drug · Other
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 45 Years to 65 Years · Female only
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Contraception, Pregnancy
Interventions: emergency contraception (estrogen/progesterone); Drug
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 15 Years to 39 Years · Female only
Enrollment: 1,100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2001 – 2004
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania

Conditions: Premature Birth
Interventions: Vaginal Progesterone gel., fetal fibronectin swab., Placebo gel; Drug · Procedure
Lead sponsor: Obstetrix Medical Group; Industry
Eligibility: 18 Years to 60 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: San Jose, California

Conditions: Cocaine Abuse, Cocaine-Related Disorders
Interventions: Progesterone, Placebo; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 46 Years
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2008
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Cocaine-Related Disorders
Interventions: Pregnenolone (PREG), Placebos; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Traumatic Brain Injury
Interventions: Pregnenolone, Placebo; Drug
Lead sponsor: Durham VA Medical Center; Federal
Eligibility: 18 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Turner Syndrome, Hypogonadism, Premature Ovarian Failure
Interventions: 17 B estradiol orally, 17 B estradiol; Drug
Lead sponsor: Nemours Children's Clinic; Other
Eligibility: 13 Years to 20 Years · Female only
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 2
States / cities: Jacksonville, Florida • Philadelphia, Pennsylvania

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A Novel Approach to Endometrial Preparation in Recipients of Donor Eggs

A Pharmacokinetic and Randomized Trial of Neoadjuvant Treatment With Anastrozole Plus AZD0530 in Postmenopausal Patients With Hormone Receptor Positive Breast Cancer

Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS)

Development of Pregnenolone as a Treatment for Depression

Mirena for the Treatment of Nonatypical Endometrial Hyperplasia for 6 Months

A Phase 3, Randomized, Three-Cycle, Double-Blind, Placebo-Controlled Study to Evaluate Induction of Secretory Conversion of Endometrium and Withdrawal Bleeding for Secondary Amenorrhea

Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes

Determining How Quickly Progesterone Slows LH Pulse Frequency

Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children

Vaginal Progesterone for the Prevention of Preterm Birth in Women With Arrested Preterm Labor

Novel Intervention for Chronic Complex TBI in OEF/OIF/OND Veterans

Progesterone Preeclampsia

Sex Hormones and Orthostatic Tolerance

Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

Traditional Clomiphene Citrate Administration vs. Stair-step Approach

Neurosteroids as Novel Therapeutic Agents for Chronic Pain in OEF/OIF Veterans

Hormone Replacement for Premature Ovarian Insufficiency

Estrogen Receptor Beta and Mood

Emergency Contraception (ECP): Reducing Unintended Pregnancies

Vaginal Progesterone in Twins With Short Cervix

Progesterone for the Treatment of Cocaine Dependence - 1

The Role of Neuroactive Steroids in Stress, Drug Craving and Drug Use in Cocaine Use Disorders

Adjunctive Pregnenolone in Veterans With Mild TBI

Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism