Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 10, 2026, 10:52 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 72 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Sham Low-Level Laser Therapy Clear all

Conditions: Chronic Low Back Pain
Interventions: Active Neurolumen, Inactive Neurolumen; Device
Lead sponsor: Defense and Veterans Center for Integrative Pain Management; Other
Eligibility: 18 Years to 70 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Portsmouth, Virginia

Conditions: Metatarsal Stress Fracture, Stress Fracture of Tibia
Interventions: Photobiomodulation Therapy with Standard Physical Therapy, Sham Photobiomodulation Therapy with Standard Physical Therapy; Device · Other
Lead sponsor: Brooke Army Medical Center; Federal
Eligibility: 17 Years to 64 Years
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Graft-Versus-Host Disease, GVHD, Undefined
Interventions: Photobiomodulation Therapy, Placebo sham device; Device · Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 4 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 9
States / cities: Bethesda, Maryland • Basking Ridge, New Jersey • Middletown, New Jersey + 6 more

Conditions: Depression
Interventions: Deprexis, Active low-level light therapy, Sham low-level light therapy; Other · Device
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 45 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Obesity
Interventions: Erchonia Obesity Laser, Placebo Laser; Device
Lead sponsor: Erchonia Corporation; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 53 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 2
States / cities: Noblesville, Indiana • Bloomfield Hills, Michigan

Conditions: Epilepsy
Interventions: Photobiomodulation; Other
Lead sponsor: Cynthia Kerson; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 4
States / cities: North Miami, Florida • Cincinnati, Ohio • Warren, Ohio + 1 more

Conditions: Wound Healing and Prevention, Oral Inflammation, Photobiomodulation, Post-operative Pain Management, Tooth Extraction Site Healing
Interventions: Low-level laser therapy; Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Androgenetic Alopecia
Interventions: LaserCap SD, Sham LaserCap, LaserCap HD+; Device
Lead sponsor: University of Arizona; Other
Eligibility: 25 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Head and Neck Cancer, Lymphedema of the Head and Neck
Interventions: LTU-904 Portable Laser Therapy Unit (active laser device), LTU-904 Portable Laser Therapy Unit (sham/inactive laser device); Device
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Nashville, Tennessee

Conditions: DENT IMPLANTS, LASER
Interventions: Conventional mechanical therapy, Saline, Methylene Blue, Light emitting laser, Non-light emitting laser; Procedure · Drug · Device
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Nociceptive Pain, Musculoskeletal Pain
Interventions: IR REHAB, Sham; Device
Lead sponsor: IR Technology, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Woodstock, Georgia

Conditions: Pain Related to TMD
Interventions: THOR® laser system; Device
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 99 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Post-traumatic Stress Disorder (PTSD)
Interventions: TILS, sham; Device
Lead sponsor: The University of Texas at Arlington; Other
Eligibility: 18 Years to 60 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Arlington, Texas

Conditions: Venous Leg Ulcer
Interventions: Summus Laser, Summus Laser Sham; Device
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: Photobiomodulation Therapy, Placebo; Other
Lead sponsor: Marquette University; Other
Eligibility: 20 Years to 60 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Ischemic Stroke
Interventions: NeuroThera® Laser System; Device
Lead sponsor: PhotoThera, Inc; Industry
Eligibility: 40 Years to 90 Years
Enrollment: 660 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 51
States / cities: Fort Smith, Arkansas • Berkeley, California • Encinitas, California + 45 more

Conditions: Macular Edema Associated With Diabetes Mellitus
Interventions: Standard of Care, Macugen; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years and older
Enrollment: 317 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2011
U.S. locations: 28
States / cities: Phoenix, Arizona • Tucson, Arizona • Los Angeles, California + 24 more

Conditions: Acute Ischemic Stroke
Interventions: NeuroThera® Laser System; Device
Lead sponsor: PhotoThera, Inc; Industry
Eligibility: 40 Years to 80 Years
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2010
U.S. locations: 26
States / cities: Birmingham, Alabama • Fort Smith, Arkansas • Encinitas, California + 23 more

Conditions: Pain
Interventions: Low level 1 Watt, Phoenix Thera-Lase System 42, Phoenix Thera-Lase System 74; Device
Lead sponsor: Phoenix Thera-lase Systems, LLC; Industry
Eligibility: 25 Years to 65 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Radiation Lymphedema, Radiation Fibrosis, Head and Neck Cancer
Interventions: Photobiomodulation (PBM) Therapy, Sham PBM; Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: New York, New York

Conditions: Body Contouring
Interventions: Erchonia ML Scanner (MLS), Sham device; Device
Lead sponsor: Erchonia Corporation; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 3
States / cities: Palm Beach Gardens, Florida • Marion, Indiana • Bloomfield Hills, Michigan

Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: photobiomodulation, Sham treatment, Physiotherapy; Device · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older · Female only
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Overweight and Obesity, Weight Loss
Interventions: Low Level Laser Therapy, Sham (placebo); Device · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Ischemic Stroke
Interventions: Transcranial Laser Therapy; Device
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 80 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 3
States / cities: Englewood, Colorado • Columbia, South Carolina • Spokane, Washington

Search by objective public record fields.

Treatment of Chronic Lower Back Pain With a Combination of Electrical Stimulation, LED, and Laser Therapy

Photobiomodulation Therapy for the Treatment of Lower Extremity Stress Fractures in a Military Training Setting

A Study of Photobiomodulation (PBM) Therapy in People With Oral Graft-Versus-Host Disease (GVHD) After Stem Cell Transplant

Augmenting Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder With Low-Level Light Therapy

Study of Low Level Laser Therapy to Reduce Body Circumference in Obese Individuals

An Examination of Whether Infrared Light Therapy Can Reduce Stress in People With Epilepsy

Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva

Sham LaserCap vs. LaserCap SD vs. LaserCap HD+

Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema

Clinical and Microbiologic Outcomes of aPDT in the Non-surgical Treatment of Implant Inflammation

Clinical Trial of the invisaRED® IR REHAB Device When Used as an Adjunctive Therapy for Nociceptive Musculoskeletal Pain

Photobiomodulation for Management of Temporomandibular Disorder Pain

Transcranial Infrared Laser Stimulation (TILS) of Prefrontal Cognition in Post-traumatic Stress Disorder (PTSD)

Randomized Controlled Trial for Treatment of Pain and Assessment of Wound Healing in Chronic Venous Leg Ulcers Using Near Infrared Laser Therapy

Photobiomodulation Therapy in Persons With Multiple Sclerosis

Effectiveness and Safety Trial of a New Ischemic Stroke Treatment Within 24 Hours From Stroke Onset (NEST-2)

A Multi-Center Trial To Evaluate The Safety And Efficacy Of Pegaptanib Sodium(Macugen) Injected Into The Eye Every 6 Weeks For Up To 2 Years For Macular Swelling Associated With Diabetes, With An Open-Label Macugen Year Extension.

Efficacy and Safety Trial of Transcranial Laser Therapy Within 24 Hours From Stroke Onset (NEST-3)

Phoenix Thera-Lase for Treating Chronic Pain in Patients Taking Opioid on a PRN Basis

Impact of Photobiomodulation (PBM) on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer Patients

Study of Low Level Laser Therapy for Body Contouring

Photobiomodulation Therapy Using the Realief Therapy System for the Treatment of Chemotherapy-associated Peripheral Neuropathy

Low-level Laser and Lifestyle Modifications

Safety of Rt-PA + Transcranial Emission of Low-Energy Lasers for Acute Stroke Recovery