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ClinicalTrials.gov public records Last synced Sep 30, 2026, 7:23 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–42 of 42 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Surgical Mitral Valve Repair Clear all
Not yet recruiting No phase listed Observational

Mitral Valve Repair With the Chord-X System: A Long Term Evaluation

NCT07413926
View directory record Official record
Conditions
Mitral Regurgitation (MR)
Interventions
Chord-X system implant
Device
Lead sponsor
Artivion Inc.
Industry
Eligibility
Not listed
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2034
U.S. locations
1
States / cities
Edgewood, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Sep 30, 2026, 7:23 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biomarkers in Aortic Stenosis - B.A.S.S.

NCT01334801
View directory record Official record
Conditions
Aortic Stenosis, Disorder of Prosthetic Cardiac Valve, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Hypertrophic Cardiomyopathy, Tricuspid Valve Insufficiency
Interventions
Blood Draw
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
21 Years and older
Enrollment
378 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Sep 30, 2026, 7:23 PM EDT
Completed No phase listed Observational

Quality of Life After Open Heart Surgery in Older Patients

NCT00248898
View directory record Official record
Conditions
Open Heart Surgery Patients
Interventions
Cardiac Surgery
Procedure
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
90 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 20, 2017 · Synced Sep 30, 2026, 7:23 PM EDT
Active, not recruiting Not applicable Interventional

Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

NCT02803957
View directory record Official record
Conditions
Mitral Valve Insufficiency
Interventions
NeoChord DS1000, Surgical Mitral Valve Repair
Device
Lead sponsor
NeoChord
Industry
Eligibility
21 Years and older
Enrollment
585 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
14
States / cities
Sacramento, California • Stanford, California • Washington D.C., District of Columbia + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 30, 2026, 7:23 PM EDT
Active, not recruiting Not applicable Interventional

PRIMARY Ancillary Substudy

NCT07103733
View directory record Official record
Conditions
Mitral Valve Prolapse, Left Ventricular Fibrosis, Ventricular Arrhythmias
Interventions
Cardiac Magnetic Resonance Imaging, ZioPatch Monitoring, Myocardial Tissue Biopsy
Procedure · Device
Lead sponsor
Annetine Gelijns
Other
Eligibility
60 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
16
States / cities
Los Angeles, California • San Francisco, California • Stanford, California + 11 more
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 30, 2026, 7:23 PM EDT
Recruiting No phase listed Observational

Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation

NCT07605715
View directory record Official record
Conditions
Degenerative Mitral Valve Disease
Interventions
Not listed
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Sep 30, 2026, 7:23 PM EDT
Not listed Not applicable Interventional Results available

Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) and COAPT CAS

NCT01626079
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Regurgitation, Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects, Heart Failure
Interventions
MitraClip System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
776 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2024
U.S. locations
81
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 65 more
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Sep 30, 2026, 7:23 PM EDT
Recruiting No phase listed Observational

Patient-Centered Approach for Treatment Decisions in Mitral Valve Prolapse

NCT06738537
View directory record Official record
Conditions
Mitral Valve Prolapse
Interventions
Focus Groups/Quantitative Survey for Patients, Focus Group/Quantitative Survey for HCPs, Qualitative Focus Group
Other
Lead sponsor
Northwell Health
Other
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
5
States / cities
Los Angeles, California • Kansas City, Missouri • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Sep 30, 2026, 7:23 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Medical Versus Surgical Management of Moderate Mitral Regurgitation Following Percutaneous Coronary Intervention

NCT01156441
View directory record Official record
Conditions
Myocardial Infarction, Mitral Regurgitation
Interventions
surgical mitral valve repair w/ mitral valve annuloplasty
Procedure
Lead sponsor
Southern Illinois University
Other
Eligibility
19 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Springfield, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 16, 2014 · Synced Sep 30, 2026, 7:23 PM EDT
Completed Not applicable Interventional Results available

ABLATE Post Approval Study - Synergy Ablation Lesions for Non-Paroxysmal Atrial Fibrillation

NCT01694563
View directory record Official record
Conditions
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Interventions
Synergy Ablation System
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years and older
Enrollment
365 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
49
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Los Angeles, California + 41 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2019 · Synced Sep 30, 2026, 7:23 PM EDT
Recruiting Not applicable Interventional

AMEND TS Early Feasibility Study

NCT06951672
View directory record Official record
Conditions
Symptomatic Functional MR 3 or Greater
Interventions
This study will evaluate the safety and functionality of the AMEND™ Trans-Septal System for annuloplasty as a therapy for mitral regurgitation.
Device
Lead sponsor
Valcare Medical Ltd.
Industry
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
11
States / cities
Phoenix, Arizona • La Jolla, California • Atlanta, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 30, 2026, 7:23 PM EDT
Completed No phase listed Observational

Testing Automated Echocardiography

NCT04943965
View directory record Official record
Conditions
This Study is Being Conducted to Collect Echocardiographic Data to Test the Lumify Ultrasound With Hemodynamic Automation Device
Interventions
Ultrasound imaging
Diagnostic Test
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 19, 2023 · Synced Sep 30, 2026, 7:23 PM EDT
Completed Not applicable Interventional Results available

EVEREST II Pivotal Study High Risk Registry (HRR)

NCT01940120
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation, Mitral Insufficiency
Interventions
Percutaneous mitral valve repair using MitraClip implant
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
2
States / cities
Evanston, Illinois • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 7, 2018 · Synced Sep 30, 2026, 7:23 PM EDT
Recruiting Not applicable Interventional

The ENCIRCLE Trial

NCT04153292
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Insufficiency
Interventions
SAPIEN M3 valve and dock
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2031
U.S. locations
56
States / cities
Huntsville, Alabama • Phoenix, Arizona • Tucson, Arizona + 46 more
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Sep 30, 2026, 7:23 PM EDT
Terminated Not applicable Interventional Results available

Improving Mitral Repair for Functional Mitral Regurgitation

NCT03366649
View directory record Official record
Conditions
Cardiomyopathy, Cardiovascular Diseases, Congestive Heart Failure, Coronary Artery Disease, Heart Disease, Valvular Heart Disease, Mitral Valve Disease
Interventions
Undersizing Mitral Annuloplasty, Papillary Muscle Approximation
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
3
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 16, 2025 · Synced Sep 30, 2026, 7:23 PM EDT
Completed Not applicable Interventional Results available

The CLASP Study Edwards PASCAL TrAnScatheter Mitral Valve RePair System Study

NCT03170349
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
Mitral Valve Repair
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
8
States / cities
Los Angeles, California • Aurora, Colorado • Evanston, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 30, 2026, 7:23 PM EDT
Not listed No phase listed Observational

Primary Mitral Regurgitation Repair

NCT04067635
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Prolapse, Chronic Mitral Disease, Mitral Regurgitation, Mitral Valve Disease, Degenerative Mitral Valve Disease, Myxomatous Mitral Valve Degeneration, Ventricular Remodeling
Interventions
Not listed
Lead sponsor
Eric Y. Yang, MD PhD
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Sep 30, 2026, 7:23 PM EDT
Active, not recruiting Not applicable Interventional

MitraClip REPAIR MR Study

NCT04198870
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
MitraClip™ device implantation, Mitral Valve Repair Surgery
Device · Procedure
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2035
U.S. locations
63
States / cities
Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 47 more
Source: ClinicalTrials.gov public record
Updated May 15, 2026 · Synced Sep 30, 2026, 7:23 PM EDT