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ClinicalTrials.gov public records Last synced Oct 19, 2026, 5:47 AM EDT

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Showing 97–117 of 117 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: TAVR Clear all
Recruiting Not applicable Interventional

TAVR vs SAVR in Severe Bicuspid Aortic Stenosis

NCT07413965
View directory record Official record
Conditions
Bicuspid Aortic Valve Disease
Interventions
Transcatheter Aortic Valve Replacement, the open chest surgery to replace the aortic valve
Procedure
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
50 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2040
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 19, 2026, 5:47 AM EDT
Completed Not applicable Interventional Results available

PROTECTED TAVR: Stroke PROTECTion With SEntinel During Transcatheter Aortic Valve Replacement

NCT04149535
View directory record Official record
Conditions
Stroke
Interventions
Sentinel® Cerebral Protection System
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
Not listed
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
41
States / cities
Tucson, Arizona • Los Angeles, California • Sacramento, California + 37 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2023 · Synced Oct 19, 2026, 5:47 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Ergonomics in the Cardiac Catheterization Laboratory

NCT06506968
View directory record Official record
Conditions
Ergonomics, Orthopedic Injury, Wellness
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 18, 2024 · Synced Oct 19, 2026, 5:47 AM EDT
Active, not recruiting Not applicable Interventional Results available

ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

NCT03735667
View directory record Official record
Conditions
Aortic Stenosis
Interventions
ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
Not listed
Enrollment
1,948 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
69
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 58 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 19, 2026, 5:47 AM EDT
Terminated Not applicable Interventional Results available

Frequency of Reduced Leaflet Motion After Surgical Aortic Valve Replacement and Transcatheter Aortic Valve Replacement.

NCT02696226
View directory record Official record
Conditions
Aortic Valve Disorder
Interventions
SAVR Warfarin, SAVR Aspirin, TAVR Warfarin and clopidogrel, TAVR Aspirin and clopidogrel
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 24, 2018 · Synced Oct 19, 2026, 5:47 AM EDT
Recruiting No phase listed Observational

Intravascular Lithotripsy in High Risk Calcified Iliac Anatomy for Transfemoral TAVR

NCT05862558
View directory record Official record
Conditions
Iliac Disease, Aortic Valve Stenosis
Interventions
Shockwave Balloon
Device
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 19, 2026, 5:47 AM EDT
Recruiting Not applicable Interventional

CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material

NCT07276711
View directory record Official record
Conditions
Aortic Valve Stenosis, Aortic Stenosis, Aortic Valve Disease
Interventions
EmStop Embolic Protection System, Boston Scientific Sentinel
Device
Lead sponsor
EmStop Inc
Industry
Eligibility
22 Years and older
Enrollment
663 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
7
States / cities
Thousand Oaks, California • Clearwater, Florida • New Orleans, Louisiana + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 19, 2026, 5:47 AM EDT
Recruiting Not applicable Interventional

ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

NCT05172973
View directory record Official record
Conditions
Aortic Valve Insufficiency, Aortic Valve Stenosis
Interventions
SAPIEN X4/X4S THV
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2039
U.S. locations
34
States / cities
Newport Beach, California • San Francisco, California • Stanford, California + 26 more
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 19, 2026, 5:47 AM EDT
Active, not recruiting Not applicable Interventional

Siegel™ Transcatheter Aortic Valve Replacement System (TAVR) Early Feasibility Study

NCT06680427
View directory record Official record
Conditions
Aortic Stenosis Symptomatic
Interventions
Siegel Transcatheter Aortic Valve (TAVR)
Device
Lead sponsor
MiRus
Industry
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
8
States / cities
Los Angeles, California • Palo Alto, California • Naples, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Oct 19, 2026, 5:47 AM EDT
Not listed Not applicable Interventional

Strategies to Prevent Transcatheter Heart Valve Dysfunction in Low Risk Transcatheter Aortic Valve Replacement

NCT03557242
View directory record Official record
Conditions
Aortic Stenosis
Interventions
TAVR, Warfarin plus Aspirin, Aspirin Only
Device · Other
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
Not listed
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
7
States / cities
San Diego, California • Washington D.C., District of Columbia • Ridgewood, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 4, 2022 · Synced Oct 19, 2026, 5:47 AM EDT
Not listed Phase 2 Interventional

TranScatheter Aortic Valve RepLacement System US Feasibility Trial

NCT01932099
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Transcatheter aortic valve replacement
Device
Lead sponsor
Direct Flow Medical, Inc.
Industry
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
6
States / cities
Sacramento, California • Chicago, Illinois • Detroit, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2016 · Synced Oct 19, 2026, 5:47 AM EDT
Completed Not applicable Interventional

Aortic Stenosis Pre-Transcatheter Aortic Valve Replacement (TAVR) Procedure CT Scan

NCT01843426
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Low-volume, low-concentration contrast (iodixanol - Visipaque 270) CT scan
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 2, 2018 · Synced Oct 19, 2026, 5:47 AM EDT
Not listed Not applicable Interventional Results available

JENAVALVE AS EFS TRIAL: Pericardial TAVR Aortic Stenosis Study

NCT02732691
View directory record Official record
Conditions
Aortic Valve Stenosis, Heart Valve Diseases, Heart Diseases, Cardiovascular Diseases, Ventricular Outflow Obstruction
Interventions
JenaValve Pericardial TAVR System
Device
Lead sponsor
JenaValve Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
2
States / cities
Washington D.C., District of Columbia • New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 22, 2022 · Synced Oct 19, 2026, 5:47 AM EDT
Completed Not applicable Interventional Results available

The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves - PII B

NCT02184442
View directory record Official record
Conditions
Severe, Symptomatic, Calcific Aortic Stenosis
Interventions
TAVR Implantation with SAPIEN XT, TAVR Implantation with SAPIEN
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
19 Years and older
Enrollment
560 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
53
States / cities
Little Rock, Arkansas • La Jolla, California • Los Angeles, California + 45 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2018 · Synced Oct 19, 2026, 5:47 AM EDT
Recruiting Not applicable Interventional

STAR Trial (Siegel Transcatheter Aortic Valve Replacement in Patients With Symptomatic Severe Aortic Stenosis)

NCT07278310
View directory record Official record
Conditions
Symptomatic Severe Native Aortic Stenosis, Aortic Stenosis
Interventions
TAVR Device, Siegel TAVR Device
Device
Lead sponsor
MiRus
Industry
Eligibility
18 Years and older
Enrollment
1,025 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 19, 2026, 5:47 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

GPx Activity in Subjects With Aortic Stenosis Undergoing TAVR

NCT04268160
View directory record Official record
Conditions
Glutathione Peroxidase Activity, Aortic Stenosis, Transcatheter Aortic Valve Replacement
Interventions
Blood draw to measure GPx activity, Blood draw to measure SOD activity, Blood draw to measure Lp(a) levels
Diagnostic Test
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 19, 2026, 5:47 AM EDT
Completed Not applicable Interventional Results available

PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - XT Intermediate and High Risk

NCT01314313
View directory record Official record
Conditions
Symptomatic Severe Aortic Stenosis
Interventions
TAVR Implantation with SAPIEN XT, SAVR Implantation
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
Not listed
Enrollment
2,032 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2024
U.S. locations
55
States / cities
Little Rock, Arkansas • La Jolla, California • Los Angeles, California + 46 more
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Oct 19, 2026, 5:47 AM EDT
Completed No phase listed Observational

Pacemaker Utilization and Ventricular Pacing in Patients Undergoing Trans-catheter Aortic Valve Replacement (TAVR)

NCT02994667
View directory record Official record
Conditions
Ventricular Flutter, Atrioventricular Block, Intraventricular Conduction Delay, Bundle Branch Block, Pacemaker Implantation
Interventions
Permanent Pacemaker Placement
Device
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jan 22, 2020 · Synced Oct 19, 2026, 5:47 AM EDT
Not listed Phase 2 Interventional

Protect the Head to Head Study

NCT05684146
View directory record Official record
Conditions
Embolism
Interventions
Emboliner Embolic Protection, Sentinel Cerebral Protection
Device
Lead sponsor
Emboline
Industry
Eligibility
18 Years and older
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
New York, New York • Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 19, 2023 · Synced Oct 19, 2026, 5:47 AM EDT
Recruiting Not applicable Interventional

J-Valve Transfemoral Pivotal Study

NCT06455787
View directory record Official record
Conditions
Aortic Valve Regurgitation, Aortic Valve Disease Mixed
Interventions
J-Valve Transfemoral (TF) System
Device
Lead sponsor
JC Medical, Inc., an affiliate of Edwards Lifesciences LLC
Industry
Eligibility
18 Years and older
Enrollment
194 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2032
U.S. locations
34
States / cities
Scottsdale, Arizona • La Jolla, California • Los Angeles, California + 26 more
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 19, 2026, 5:47 AM EDT
Active, not recruiting Not applicable Interventional

Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR

NCT05295628
View directory record Official record
Conditions
Aortic Valve Stenosis, Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Valve Replacement
Interventions
EMBLOK™ Embolic Protection System ("EMBLOK EPS"), SENTINEL™ Cerebral Protection System
Device
Lead sponsor
Emblok, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
532 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
23
States / cities
Chandler, Arizona • Orange, California • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Oct 19, 2026, 5:47 AM EDT