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ClinicalTrials.gov public records Last synced Oct 16, 2026, 5:57 AM EDT

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Showing 697–720 of 3,100 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Treatment of depression Clear all
Not listed Phase 3 Interventional

A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder

NCT00978484
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Virtual Reality Exposure Therapy - Dynamic, Augmented Exposure Therapy
Behavioral
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
2
States / cities
Camp Pendlton, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 30, 2014 · Synced Oct 16, 2026, 5:57 AM EDT
Withdrawn Early Phase 1 Interventional

Relapse Prevention in Stimulant Use Disorder

NCT04553263
View directory record Official record
Conditions
Stimulant Use, Relapse, Cognitive Function, ADHD
Interventions
Contrave 8Mg-90Mg Extended-Release Tablet, Bupropion
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 22, 2023 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Not applicable Interventional

Feasibility of a Behavioral Activation Trial

NCT02992158
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
behavioral activation, treatment-as-usual
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Oct 16, 2026, 5:57 AM EDT
Not listed Not applicable Interventional

TAO Outpatient Trial for Anxiety and Depression

NCT03390218
View directory record Official record
Conditions
Anxiety Disorders, Depression
Interventions
Therapy Assistance Online, Treatment as usual
Behavioral
Lead sponsor
TAO Connect, Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Ogden, Utah
Source: ClinicalTrials.gov public record
Updated Jan 4, 2018 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Use of a Novel Fibrin Sealant in Total Knee Arthroplasty

NCT01656759
View directory record Official record
Conditions
Osteoarthritis, Intraoperative Bleeding
Interventions
Evicel Fibrin Spray
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Oak Park, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 9, 2016 · Synced Oct 16, 2026, 5:57 AM EDT
Terminated Phase 2 Interventional

Asenapine for Bipolar Depression

NCT01807741
View directory record Official record
Conditions
Bipolar Depression
Interventions
Asenapine, Placebo
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 55 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Oct 16, 2026, 5:57 AM EDT
Not listed Not applicable Interventional

Psychosocial Treatment of Depression in Parkinson's Disease

NCT00853346
View directory record Official record
Conditions
Major Depressive Disorder, Parkinson's Disease
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Amy Farabaugh, PhD
Other
Eligibility
40 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 16, 2012 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Not applicable Interventional Results available

Targeting HIV Retention and Improved Viral Load Through Engagement ('THRIVE')

NCT04481373
View directory record Official record
Conditions
Human Immunodeficiency Virus, Depression, Anxiety
Interventions
THRIVE, Treatment as Usual
Behavioral · Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 16, 2026, 5:57 AM EDT
Withdrawn Phase 2 Interventional

MDMA-Assisted Psychotherapy for Treatment Resistant PTSD in Adolescents

NCT06353282
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder, Adolescents, Psychotherapy
Interventions
MDMA, Psychotherapy
Drug · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
16 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Phase 4 Interventional Results available

The Effect on Depressive Symptoms in ECF Residents With COPD

NCT00974246
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease, Depression
Interventions
Advair diskus
Drug
Lead sponsor
Valley Medical Research
Other
Eligibility
18 Years to 94 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Brooksville, Florida • Centerville, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 28, 2016 · Synced Oct 16, 2026, 5:57 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Smart Talk: Cannabis Awareness and Prevention Curriculum Evaluation

NCT07357454
View directory record Official record
Conditions
Cannabis Use
Interventions
Behavioral: Smart Talk Cannabis Awareness and Prevention
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
10 Years to 20 Years
Enrollment
10,800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Not applicable Interventional

Randomized, School-based Effectiveness Trial of the Adolescent Depression Awareness Program

NCT02099305
View directory record Official record
Conditions
Adolescent - Emotional Problem, Depression, Prevention Harmful Effects
Interventions
Adolescent Depression Awareness Program (ADAP)
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
12 Years to 18 Years
Enrollment
17,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 12, 2017 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Not applicable Interventional Results available

Healthy Hearts Healthy Minds

NCT03373110
View directory record Official record
Conditions
Cardiovascular Diseases, Depression
Interventions
Online Mindfulness Based Cognitive Therapy, Online Cognitive Behavioral Therapy, Fitbit Alone
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
506 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 2, 2022 · Synced Oct 16, 2026, 5:57 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

Developing a Virtual Stress Management Intervention for Spousal/Partnered Caregivers of Solid Tumor Cancer Patients.

NCT04739696
View directory record Official record
Conditions
Breast Cancer, Lung Cancer, Colon Cancer, Solid Tumor, Adult
Interventions
PEPRR, Pep-Pal
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 64 Years
Enrollment
538 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 16, 2026, 5:57 AM EDT
Recruiting Phase 3 Interventional

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

NCT07573176
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
Seltorexant, Placebo
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 74 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
34
States / cities
Bryant, Arkansas • Bellflower, California • Glendale, California + 27 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Not applicable Interventional

Integrated Parent Training for Treating Depression in Mothers of Children With Attention Deficit Hyperactivity Disorder

NCT00316290
View directory record Official record
Conditions
Depression, Attention Deficit Disorder With Hyperactivity
Interventions
Integrated Parent Training, Behavioral Parent Training
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
6 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 11, 2023 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Phase 3 Interventional Results available

Rhodiola Rosea Therapy of Major Depressive Disorder

NCT01098318
View directory record Official record
Conditions
Depression
Interventions
Herbal extract, Sertraline, Lactose monohydrate
Dietary Supplement · Drug · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 80 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Oct 16, 2026, 5:57 AM EDT
Not yet recruiting Not applicable Interventional

VOCALE LBD: Online Peer Support for Caregivers of People With Lewy Body Dementia

NCT07637097
View directory record Official record
Conditions
Lewy Bodies Disease, Depression Disorder, Caregiver Burden, Caregivers
Interventions
VOCALE LBD: Virtual Online Communities for Aging Life Experiences: Lewy Body Dementia, Standard of Care Educational Materials
Behavioral · Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Not applicable Interventional Results available

Evaluation of a Therapeutic Mobile App for Depression

NCT05601362
View directory record Official record
Conditions
Depression
Interventions
Gamified Attention Bias Modification, Gamified Placebo Training
Device
Lead sponsor
Christopher G. Beevers
Other
Eligibility
18 Years to 45 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Phase 4 Interventional Results available

Vortioxetine for Menopausal Depression

NCT02234362
View directory record Official record
Conditions
Depression, Menopause, Vasomotor Disturbance, Hot Flashes, Sleep
Interventions
vortioxetine
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
40 Years to 62 Years · Female only
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2017 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Not applicable Interventional

Adapting Cognitive Behavioral Therapy (CBT) for Chinese Americans

NCT01786746
View directory record Official record
Conditions
Major Depression
Interventions
cognitive behavioral therapy, culturally adapted cognitive behavioral therapy
Behavioral
Lead sponsor
Claremont McKenna College
Other
Eligibility
18 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Claremont, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2013 · Synced Oct 16, 2026, 5:57 AM EDT
Active, not recruiting No phase listed Observational

Long-Term Follow-Up in Women With Early Breast Cancer Three Years of More Post Primary Treatment

NCT05926024
View directory record Official record
Conditions
Breast Cancer
Interventions
Exercise Recall Patient Reported Outcomes, Health Behavior Questionnaire (HBQ)30 Patient Reported Outcomes, Functional Assessment of Cancer Therapy-General (FACT-G) Patient Reported Outcomes, Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Patient Reported Outcomes, Patient Reported Outcomes PROMIS Cognitive Function (Short Form 8a), Patient Reported Outcomes Functional Assessment of Cancer-Gynecology Oncology Group-Neurotoxicity (FACT/GOG-NTX-12), Patient Reported Outcomes PROMIS, Patient Reported Outcomes FACT-Endocrine Symptoms, Patient Reported Outcomes Penn Arthralgia Aging Survey, Patient Reported Outcomes PRO-CTCAE (patient-reported CTCAE), p16 tumor suppressor gene
Behavioral · Diagnostic Test
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
21 Years and older · Female only
Enrollment
253 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment

NCT01876823
View directory record Official record
Conditions
Mild Cognitive Impairment, Major Depressive Disorder, Alzheimer's Disease
Interventions
es-citalopram, Memantine
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
50 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 24, 2014 · Synced Oct 16, 2026, 5:57 AM EDT
Completed Phase 2 Interventional

Add-On Study of MSI-195 (S-Adenosyl-L-Methionine, SAMe) for Patients With Major Depressive Disorder (MDD)

NCT01912196
View directory record Official record
Conditions
Major Depressive Disorder (MDD)
Interventions
MSI-195, Placebo
Drug
Lead sponsor
MSI Methylation Sciences, Inc.
Industry
Eligibility
21 Years to 70 Years
Enrollment
376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
35
States / cities
Birmingham, Alabama • Encino, California • Escondido, California + 30 more
Source: ClinicalTrials.gov public record
Updated Mar 18, 2016 · Synced Oct 16, 2026, 5:57 AM EDT