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ClinicalTrials.gov public records Last synced Nov 4, 2026, 12:10 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 2233–2256 of 3,107 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Treatment of depression Clear all

Conditions: Depression, Dysthymia
Interventions: escitalopram and sertraline; Drug
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2006
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Postpartum Health, Breastfeeding, Contraception, Preventive Care / Anticipatory Guidance, Retention in Care
Interventions: Patient Navigation Program; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 16 Years to 50 Years · Female only
Enrollment: 405 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Bipolar Disorder, Depression
Interventions: Supportive Psychotherapy, Cognitive Behavioral Therapy (CBT); Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hearing Loss, Depression
Interventions: Phonak Audeo B-R 90 hearing aid device (Active), Duloxetine or escitalopram, Audeo B-R 90 hearing aid device (Sham); Device · Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 60 Years to 99 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Depressive Disorder, Depression
Interventions: Telephone cognitive behavioral therapy; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 85 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 3
States / cities: San Francisco, California • Hines, Illinois

Conditions: Major Depressive Disorder
Interventions: Vortioxetine; Drug
Lead sponsor: H. Lundbeck A/S; Industry
Eligibility: 18 Years and older
Enrollment: 992 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 31
States / cities: Dothan, Alabama • Tucson, Arizona • Newport Beach, California + 27 more

Conditions: Stimulant Use, Relapse, Cognitive Function, ADHD
Interventions: Contrave 8Mg-90Mg Extended-Release Tablet, Bupropion; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Posttraumatic Stress Disorder, Cancer
Interventions: Cancer Distress Coach Mobile App; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 569 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cancer
Interventions: BfitBwell program, 6 bi-weekly PA Behavior Change counseling sessions; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: Not listed
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Anxiety, Anxiety Disorders, Behavioral Symptoms, Depression, Mental Disorders, Stress Disorders, Post-Traumatic, Stress Disorders, Traumatic, Trauma and Stressor Related Disorders, Wounds and Injuries
Interventions: Working on Womanhood (WOW); Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: Female only
Enrollment: 5,106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Major Depression
Interventions: functional Near Infrared Spectroscopy; Device
Lead sponsor: Mclean Hospital; Other
Eligibility: 21 Years to 45 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 2
States / cities: Belmont, Massachusetts

Conditions: Onychophagia
Interventions: N-Acetylcysteine (NAC), Placebo; Drug · Other
Lead sponsor: Kevin Gray, MD; Other
Eligibility: 18 Years to 30 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Bipolar Disorder
Interventions: Magnetic Resonance Imaging; Other
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Bipolar Depression
Interventions: Uridine; Drug
Lead sponsor: Repligen Corporation; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Timeline: Started 2006
U.S. locations: 11
States / cities: Stanford, California • Smyrna, Georgia • Indianapolis, Indiana + 8 more

Conditions: Mood Disorders, Substance-Related Disorders
Interventions: Facilitate evidence-based treatment for depression; Procedure
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: Not listed
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 5
States / cities: No. Little Rock, Arkansas • New Orleans, Louisiana • Biloxi, Mississippi + 2 more

Conditions: Depression
Interventions: Continuation phase cognitive therapy, Continuation phase fluoxetine, Continuation phase pill placebo, Acute phase cognitive therapy; Behavioral · Drug · Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 70 Years
Enrollment: 523 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2008
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania • Dallas, Texas

Conditions: Cystic Fibrosis, Depression, Anxiety
Interventions: Cognitive Behavioral Therapy (CBT); Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 12 Years to 17 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 3
States / cities: Kansas City, Kansas • Boston, Massachusetts • New York, New York

Conditions: Major Depressive Disorder
Interventions: ALKS 5461; Drug
Lead sponsor: Alkermes, Inc.; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 8
States / cities: Jacksonville, Florida • Orlando, Florida • Atlanta, Georgia + 5 more

Conditions: Stress, Anxiety, Depression
Interventions: Kelee Meditation; Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 65 Years
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 2
States / cities: San Diego, California

Conditions: Depression
Interventions: Behavioral Activation for Depression; Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 65 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cognitive-affective Exercises, Engaging Exercises
Interventions: Therapeutic Computerized intervention, Nontherapeutic computerized intervention; Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 89 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Stanford, California

Conditions: Depressive Disorder, Major
Interventions: Radafaxine; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 64 Years
Enrollment: 365 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2004
U.S. locations: 21
States / cities: Cerritos, California • San Diego, California • Washington D.C., District of Columbia + 18 more

Conditions: Major Depressive Disorder, Depression
Interventions: TC-5214, Placebo; Drug
Lead sponsor: AstraZeneca; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 319 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 37
States / cities: Tuscaloosa, Alabama • Tucson, Arizona • Little Rock, Arkansas + 34 more

Conditions: Anxiety, Depression, Insomnia, Sleep Quality
Interventions: Alpha-Stim AID CES (Active Comparator), Alpha-Stim AID CES (Sham Comparator); Device
Lead sponsor: Christina Murphey, RN, PhD; Individual
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 1 participant
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 2
States / cities: Austin, Texas • Corpus Christi, Texas

Search by objective public record fields.

Medications for the Treatment of Dysthymic Disorder and Double Depression

Navigating New Motherhood 2

Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder

Treating Hearing Loss to Improve Mood and Cognition in Older Adults

Telephone Administered Psychotherapy for the Treatment of Depression for Veterans in Rural Areas

Real-life Effectiveness of Vortioxetine in Depression

Relapse Prevention in Stimulant Use Disorder

Cancer Distress Coach Mobile App Trial

Improving Physical Activity Maintenance of Cancer Survivors

The Impact of a School-Based, Trauma-Informed CBT Intervention for Young Women

Functional Brain Imaging Study of Response to Repetitive TMS (rTMS) Treatment of Major Depression

Use of N-Acetylcysteine (NAC) in Fingernail Biting

Rostral Dorsal Cingulum Bundle Connectivity in Patients With Bipolar Disorder

Phase II Study to Assess RG2417 in the Treatment of Bipolar I Depression

Facilitating the Adoption of Evidence-Based Depression Management in Substance Use Treatment Programs

Cognitive Therapy for Recurrent Depression

Pilot Study of a CF-specific CBT Intervention for Adolescents

A Study of Different Titration Schedules of ALKS 5461 in Adults With Major Depressive Disorder (MDD)

Kelee® Meditation: A Distinctive and Effective Therapeutic Intervention for Stress, Anxiety, and Depression

Management of Depression and Social Isolation in Older Adults With Dementia With Home-based Telehealth Delivered Behavioral Activation + Caregiver Facilitation.

Trial of a Nationwide Cognitive-Affective Remediation Training Intervention in Depression

An 8 Week Study Of Adults Diagnosed With Major Depressive Disorder

A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder (MDD)

Efficacy of CES in New Mothers During the Post Partum Period