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ClinicalTrials.gov public records Last synced Nov 7, 2026, 12:27 AM EST

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Showing 25–48 of 48 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: VNS device Clear all

Conditions: Chronic Stroke
Interventions: Vagus Nerve Stimulation (VNS) Device, Sham VNS Device, Upper Extremity Rehabilitation; Device · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 22 Years to 79 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: New York, New York • Richardson, Texas

Conditions: Vagus Nerve Stimulation
Interventions: Transcutaneous electrical auricular vagus nerve stimulation (VNS); Device
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years and older
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Manhasset, New York

Conditions: Autism Spectrum Disorder, Intellectual Disability, Autonomic Nervous System, Developmental Disability
Interventions: Vagus Nerve Stimulation; Device
Lead sponsor: New York State Institute for Basic Research; Government
Eligibility: 12 Years to 40 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: New York, New York • Staten Island, New York

Conditions: Treatment Resistant Depression
Interventions: Vagus Nerve Stimulation; Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Stanford, California

Conditions: Post COVID-19, Cognitive Dysfunction
Interventions: Parasym Device (of Parasym Ltd, UK) using Transcutaneous Vagus Nerve Stimulation (t-VNS); Device
Lead sponsor: Casa Colina Hospital and Centers for Healthcare; Other
Eligibility: 18 Years to 85 Years · Female only
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Pomona, California

Conditions: Cluster Headache
Interventions: GammaCore, Sham GammaCore device; Device
Lead sponsor: ElectroCore INC; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 20
States / cities: Santa Monica, California • Stanford, California • Englewood, Colorado + 17 more

Conditions: PostTraumatic Stress Disorder
Interventions: GammaCore/electroCore non-invasive VNS device, Sham gammaCore/electroCore, O-15 water; Device · Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Migraine
Interventions: n-VNS; Device
Lead sponsor: ElectroCore INC; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 3
States / cities: San Francisco, California • New York, New York • The Bronx, New York

Conditions: Cervical Spinal Cord Injury
Interventions: Active VNS, Sham VNS, Arm rehabilitation; Device · Other
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation
Interventions: Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches; Combination Product · Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Stroke, Chronic Stroke, Upper Extremity Paresis, Ischemic Stroke, Hemorrhagic Stroke
Interventions: Active Vagus Nerve Stimulation, Placebo Vagus Nerve Stimulation; Device
Lead sponsor: Baylor Research Institute; Other
Eligibility: 22 Years to 79 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Cerebral Palsy
Interventions: Non-invasive taVNS; Device
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 12 Years to 17 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Treatment Resistant Depression
Interventions: Vagus Nerve Stimulation (VNS); Device
Lead sponsor: LivaNova; Industry
Eligibility: 18 Years and older
Enrollment: 6,800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2030
U.S. locations: 101
States / cities: Birmingham, Alabama • Huntsville, Alabama • Burlingame, California + 85 more

Conditions: Parkinson's Disease
Interventions: non-invasive cervical vagal nerve stimulation ncVNS; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 50 Years to 88 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Hines, Illinois

Conditions: Spinal Cord Injuries, Upper Extremity Paresis
Interventions: Active Vagus Nerve Stimulation, Placebo Vagus Nerve Stimulation; Device
Lead sponsor: Baylor Research Institute; Other
Eligibility: 18 Years to 64 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Chronic Ischemic Stroke
Interventions: Vivistim; Device
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Autoimmune Diseases, Epilepsy, Autonomic Dysfunction, Inflammatory Bowel Diseases
Interventions: Vagal nerve stimulation (VNS); Device
Lead sponsor: University of Louisville; Other
Eligibility: 0 Years to 60 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 4
States / cities: Louisville, Kentucky • Houston, Texas • Salt Lake City, Utah

Conditions: Spinal Cord Injury (SCI), Gait, Reduced Physical Activity, Lower Limb Functions, Walking Impairment, Mobility Impairment, Functional Mobility
Interventions: CLV, Sham; Device
Lead sponsor: The University of Texas at Dallas; Other
Eligibility: 18 Years to 64 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 4
States / cities: Boston, Massachusetts • Dallas, Texas • Richardson, Texas

Conditions: Stroke, Cerebrovascular Accident (CVA), Hemiparesis
Interventions: Transcutaneous Vagus Nerve Stimulation (tVNS), Sham Transcutaneous Vagus Nerve Stimulation (tVNS); Device
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years to 85 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Manhasset, New York

Conditions: Hypoxia-Ischemia, Brain
Interventions: taVNS; Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 7 Years to 18 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: PARKINSON DISEASE (Disorder), Parkinson's Disease (PD)
Interventions: Vagal nerve stimulation, No intervention; Device · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 21 Years to 76 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Epilepsy
Interventions: VNS stimulation and intraneural recordings, Record multi-unit activity from intraneural sites; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 40 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Fibromyalgia (FM), Posttraumatic Stress Disorder (PTSD)
Interventions: tAN plus PEPC, sham plus PEPC; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2030
U.S. locations: 1
States / cities: Decatur, Georgia

Conditions: Epilepsies, Partial, Epilepsy, Tonic-Clonic
Interventions: Microburst Stimulation; Device
Lead sponsor: LivaNova; Industry
Eligibility: 12 Years and older
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 8
States / cities: Birmingham, Alabama • Denver, Colorado • Jacksonville, Florida + 5 more

Search by objective public record fields.

Paired Vagus Nerve Stimulation Mechanisms

Effect of Transcutaneous Electrical Auricular Stimulation of the Vagus Nerve in Kidney Transplant Recipients

Vagus Nerve Stimulator for Autism and Other Developmental Disorders

Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement

Multimodal Investigation of Post COVID-19 in Females

Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache

Closed Loop Vagal Nerve Stimulation for Patients With Posttraumatic Stress Disorder

Non-Invasive Neurostimulation For the Relief of Symptoms Associated With Migraine

Safety and Feasibility of Paired Vagus Nerve Stimulation With Rehabilitation for Improving Upper Extremity Function in People With Cervical Spinal Cord Injury

A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation

Wireless Nerve Stimulation Device To Enhance Recovery After Stroke

Paired Non-invasive VNS in Adolescent Cerebral Palsy Rehabilitation

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Non-invasive VNS for Parkinson's Gait

Targeted Plasticity Therapy for Upper Limb Rehabilitation in Spinal Cord Injuries

Vagal Nerve Stimulation in Enhanced Stroke Recovery: The VALOR Registry

VNS Prospective Neuromodulation of Immune and Gastrointestinal Systems

Closed-Loop Vagus Nerve Stimulation (CLV) for Recovery of Gait After Spinal Cord Injury (SCI)

Transcutaneous Vagus Nerve Stimulation (tVNS) and Robotic Training to Improve Arm Function After Stroke

Transauricular Vagus Nerve Stimulation in Children

Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease

Microelectrode Recordings From the Vagus Nerve in Awake Humans

Treatment of Fibromyalgia and PTSD With Live and Inactive Vagus Nerve Stimulation With PEPC

Microburst Vagus Nerve Stimulator (VNS) Therapy Feasibility Study