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ClinicalTrials.gov public records Last synced Nov 6, 2026, 1:51 PM EST

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Showing 1–24 of 168 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Vitamin B-12 Clear all

Conditions: Alzheimer's Disease
Interventions: Folate, Vitamin B6, Vitamin B12; Drug
Lead sponsor: National Institute on Aging (NIA); NIH
Eligibility: 55 Years and older
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2007
U.S. locations: 38
States / cities: Birmingham, Alabama • Scottsdale, Arizona • Sun City, Arizona + 29 more

Conditions: Dietary Supplements
Interventions: Emergen-C Core Super Orange Powder, Placebo; Dietary Supplement
Lead sponsor: HALEON; Industry
Eligibility: 18 Years to 64 Years
Enrollment: 299 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Bipolar Disorder
Interventions: Metformin, healthy lifestyle intervention (LIFE); Drug · Behavioral
Lead sponsor: Melissa Delbello; Other
Eligibility: 8 Years to 19 Years
Enrollment: 1,565 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2023
U.S. locations: 29
States / cities: Covington, Kentucky • Neptune City, New Jersey • Amityville, New York + 13 more

Conditions: Maternal and Child Health Outcomes
Interventions: Vitamin A alone, Multivitamins excluding vitamin A, multivitamins including vitamin A, Placebo; Dietary Supplement · Other
Lead sponsor: Harvard School of Public Health (HSPH); Other
Eligibility: 18 Years and older · Female only
Enrollment: 771 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Bioavailability of Vitamin B12 From Chicken Eggs
Interventions: Not listed
Lead sponsor: USDA, Western Human Nutrition Research Center; Federal
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Davis, California

Conditions: Poor Energy Levels, Poor Metabolism, Difficulty With Weight Management, Bloating
Interventions: Love Wellness Energize; Dietary Supplement
Lead sponsor: Love Wellness; Industry
Eligibility: 25 Years to 45 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Parkinson Disease (PD)
Interventions: Guided Cycling, Non-Contact Boxing, Traditional Physical Therapy Program (Standard of Care); Behavioral
Lead sponsor: University of Texas, El Paso; Other
Eligibility: 50 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: El Paso, Texas

Conditions: Bariatric Surgery Candidate, Vitamin Deficiency, Mineral Deficiency
Interventions: Patch MD MultiVitamin Plus patch; Dietary Supplement
Lead sponsor: University of Florida; Other
Eligibility: 18 Years and older
Enrollment: 99 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Major Surgery, Coronary Artery Disease
Interventions: Vitamin B12 and folic acid, Nitrous oxide and placebo, standard of care; Drug · Other
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 687 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2016
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Stroke, Cerebral Infarction, Myocardial Infarction
Interventions: pyridoxine, cyanocobalamin, folic acid multivitamin; Drug
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: 35 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1996 – 2004
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Vitamin B-12 Deficiency, Achlorhydria
Interventions: 14C-B12 fortified bread; Other
Lead sponsor: USDA, Western Human Nutrition Research Center; Federal
Eligibility: 60 Years and older
Enrollment: 6 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Davis, California

Conditions: Non-small Cell Lung Cancer
Interventions: Pralatrexate, Erlotinib, Vitamin B12, Folic Acid; Drug · Dietary Supplement
Lead sponsor: Spectrum Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 201 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 15
States / cities: Bakersfield, California • San Diego, California • Port Saint Lucie, Florida + 12 more

Conditions: Chronic Pain
Interventions: Inflammation Support Formula, Nerve Health Formula, Redox Support Formula; Dietary Supplement
Lead sponsor: Ethos Research & Development; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Newport, Kentucky

Conditions: Schizophrenia
Interventions: Folic Acid, B12, Placebo; Dietary Supplement · Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 68 Years
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 3
States / cities: Boston, Massachusetts • Grand Rapids, Michigan • Rochester, New York

Conditions: Relapsed or Refractory Lymphoproliferative Malignancies, Hodgkin's Lymphoma, Peripheral T-cell Lymphoma, B-cell Lymphoma, Waldenstrom's Macroglobulinemia
Interventions: Pralatrexate Injection, Gemcitabine Hydrochloride, Vitamin B12, Folic Acid; Drug · Dietary Supplement
Lead sponsor: Acrotech Biopharma Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 119 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 15
States / cities: Los Angeles, California • Stanford, California • Denver, Colorado + 11 more

Conditions: Autistic Disorder
Interventions: Methyl B12, Placebo; Drug · Dietary Supplement
Lead sponsor: University of California, San Francisco; Other
Eligibility: 3 Years to 7 Years
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: San Francisco, California

Conditions: SARS-CoV-2, Influenza
Interventions: Influenza Vaccine 1, mRNA-1083.1, mRNA-1083.2, mRNA-1083.3, Investigational Influenza Vaccine 1, Investigational COVID-19 Vaccine 1, COVID-19 Vaccine 1, Investigational Influenza Vaccine 2, Influenza Vaccine 2, mRNA-1083, Investigational COVID-19 Vaccine 2, COVID-19 Vaccine 2; Biological
Lead sponsor: ModernaTX, Inc.; Industry
Eligibility: 18 Years to 79 Years
Enrollment: 1,758 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 69
States / cities: Chandler, Arizona • Colton, California • Huntington Beach, California + 59 more

Conditions: Obesity, Hypertension
Interventions: Phentermine and B12, Phentermine; Drug
Lead sponsor: Dr. Michael Lang; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Greenville, North Carolina

Conditions: Blood Pressure, Endothelial Dysfunction
Interventions: Plant based bioequivalent Nitrate supplementation, Placebo; Dietary Supplement
Lead sponsor: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center; Other
Eligibility: 40 Years to 75 Years
Enrollment: 67 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Torrance, California

Conditions: Vitamin B12 Deficiency
Interventions: blood collection, treatment (cyanocobalamin nasal spray); Other · Drug
Lead sponsor: University of Delaware; Other
Eligibility: 60 Years to 89 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2008
U.S. locations: 2
States / cities: Manchester, Maryland • Timonium, Maryland

Conditions: Chordomas, Chordoma
Interventions: Pembrolizumab, Pemetrexed Phase 2; Drug
Lead sponsor: Saint John's Cancer Institute; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Lung Cancer
Interventions: Bevacizumab, Pemetrexed, Radiotherapy, Folic Acid, vitamin B12, carboplatin; Drug · Procedure · Other
Lead sponsor: SCRI Development Innovations, LLC; Other
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 7
States / cities: Gainesville, Florida • Lakeland, Florida • Marietta, Georgia + 4 more

Conditions: End Stage Renal Disease, Hyperhomocysteinemia
Interventions: cyanocobalamin, folic acid, pyridoxine; Drug
Lead sponsor: Georgetown University; Other
Eligibility: 21 Years to 89 Years
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2000
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Type 2 Diabetic Peripheral Neuropathy (DPN)
Interventions: Metanx (a medical food), Metanx placebo; Other
Lead sponsor: Pamlab, Inc.; Industry
Eligibility: 25 Years to 80 Years
Enrollment: 214 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 6
States / cities: Birmingham, Alabama • New Orleans, Louisiana • Omaha, Nebraska + 3 more

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VITAL - VITamins to Slow ALzheimer's Disease (Homocysteine Study)

A Study Evaluating Quality of Life Parameters Following Use of Emergen-C

Metformin for Overweight & OBese ChILdren and Adolescents With BDS Treated With SGAs

Vitamins, Breastmilk HIV Shedding, and Child Health

Assessment of Vitamin B12 Bioavailability From Egg

A Clinical Trial to Evaluate the Effects of a Supplement on Supporting Signs of a Healthy Metabolism

Changes in Movement, Fitness, and Quality of Life in People With Parkinson's Disease After Different Exercise Programs

Absorption of Transdermal Vitamins in Post Bariatric Surgery Patients

Vitamins in Nitrous Oxide Study

Vitamin Therapy for Prevention of Stroke

Cobalamin Absorption From Fortified Food

Study of Pralatrexate vs. Erlotinib for Non-Small Cell Lung Cancer After at Least 1 Prior Platinum-based Treatment

Pilot Study: Impact of Biomarker-Guided Dietary Supplementation on Quality-of-Life Measures in Subjects With Chronic Pain

Effectiveness of Vitamin Supplementation in Treating People With Residual Symptoms of Schizophrenia

Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies

Trial of Methyl B12 on Behavioral and Metabolic Measures in Children With Autism

A Study of mRNA-based Influenza and SARS-CoV-2 (COVID-19) Multi-component Vaccines in Healthy Adults

The Effect of Phentermine and B12 on Weight Loss Among Obese Patients

Effect of Inorganic Nitrate Supplement on Blood Pressure

Long-term Use of Proton Pump Inhibitors May Cause Vitamin B12 Deficiency in the Institutionalized Elderly

Pembrolizumab and Pemetrexed for Progressive Chordoma

Chemotherapy, Radiotherapy and Bevacizumab in Patients With Unresectable Stage III Non-Small-Cell Lung Cancer

Randomized Study of Folic Acid Therapy for Hyperhomocysteinemia in Patients With End Stage Renal Disease Receiving Hemodialysis

Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN)