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Showing 1–14 of 14 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: contractility assessment Clear all
Completed Not applicable Interventional Results available

Evaluation of the Safety and Effectiveness of the OPTIMIZER System in Subjects With Heart Failure: FIX-HF-5

NCT00112125
View directory record Official record
Conditions
Heart Failure, Congestive
Interventions
OPTIMIZER System
Device
Lead sponsor
Impulse Dynamics
Industry
Eligibility
18 Years and older
Enrollment
428 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2019
U.S. locations
1
States / cities
Orangeburg, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2020 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Phase 2 Interventional Results available

COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure

NCT01786512
View directory record Official record
Conditions
Modified Release Oral Formulation, Left Ventricular Systolic Dysfunction, Chronic Heart Failure, History of Chronic Heart Failure, Left Ventricular Ejection Fraction, Pharmacokinetics, Echocardiogram
Interventions
Omecamtiv Mecarbil Matrix F1 Formulation, Omecamtiv Mecarbil Matrix F2 Formulation, Placebo, Omecamtiv Mecarbil Swellable Core Technology F2
Drug
Lead sponsor
Cytokinetics
Industry
Eligibility
18 Years to 85 Years
Enrollment
544 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
38
States / cities
Mobile, Alabama • Costa Mesa, California • Fresno, California + 34 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2021 · Synced Sep 4, 2026, 2:17 AM EDT
Terminated No phase listed Observational

Cardiac Output in Heart Failure Patients With Mechanical Pumps

NCT05195931
View directory record Official record
Conditions
Heart Failure, Systolic, Mechanical Circulatory Support, Cardiovascular Hemodynamics
Interventions
preload challenge, afterload challenge, contractility assessment
Diagnostic Test
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 80 Years
Enrollment
7 participants
Timeline
2021 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Sep 4, 2026, 2:17 AM EDT
Terminated No phase listed Observational Results available

Arrythmia Burden in Cardiac Contractility Modulation (CCM)

NCT05704426
View directory record Official record
Conditions
Atrial Fibrillation, Arrythmia
Interventions
Impulse Dynamics Optimizer Device
Device
Lead sponsor
Hackensack Meridian Health
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Hackensack, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Phase 4 Interventional Results available

Evaluation of Gallbladder Contractility Using Both CCK and Milk Consecutively

NCT02748525
View directory record Official record
Conditions
Abdominal Pain
Interventions
Milk, CCK
Other · Biological
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 1, 2019 · Synced Sep 4, 2026, 2:17 AM EDT
Terminated Phase 2 Interventional Results available

Hemodynamic and Echocardiographic Assessment of Riociguat Effects on Myocardial Wall Contractility and Relaxation Kinetics

NCT01065051
View directory record Official record
Conditions
Hypertension, Pulmonary, Ventricular Dysfunction, Left
Interventions
Riociguat (Adempas, BAY63-2521), Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
2
States / cities
Boston, Massachusetts • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 5, 2014 · Synced Sep 4, 2026, 2:17 AM EDT
Recruiting Not applicable Interventional

Assessment of CCM in HF With Higher Ejection Fraction

NCT05064709
View directory record Official record
Conditions
Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Moderately Reduced Ejection Fraction, Diastolic Heart Failure
Interventions
Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, OPTIMIZER™ Smart Mini System
Device
Lead sponsor
Impulse Dynamics
Industry
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
105
States / cities
Birmingham, Alabama • Mesa, Arizona • Phoenix, Arizona + 79 more
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 4, 2026, 2:17 AM EDT
Terminated Phase 1 Interventional

Muscle Derived Cell Therapy for Bladder Exstrophy Epispadias Induced Incontinence

NCT01011777
View directory record Official record
Conditions
Bladder Exstrophy, Urinary Incontinence
Interventions
MDC
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
2 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional Results available

Evaluate Safety and Efficacy of the OPTIMIZER® System in Subjects With Moderate-to-Severe Heart Failure: FIX-HF-5C

NCT01381172
View directory record Official record
Conditions
NYHA Class III Heart Failure, NYHA Class IV Heart Failure
Interventions
Optimizer System, No intervention: Optimal medical therapy
Device · Other
Lead sponsor
Impulse Dynamics
Industry
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
32
States / cities
Glendale, Arizona • Mesa, Arizona • Phoenix, Arizona + 26 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Sep 4, 2026, 2:17 AM EDT
Terminated Not applicable Interventional Results available

Continued Access Protocol for the Evaluation of the OPTIMIZER Smart System

NCT03102437
View directory record Official record
Conditions
Heart Failure, Congestive Heart Failure, Chronic Heart Disease, CHF
Interventions
Optimizer Smart System
Device
Lead sponsor
Impulse Dynamics
Industry
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
17
States / cities
Mesa, Arizona • Phoenix, Arizona • Scottsdale, Arizona + 10 more
Source: ClinicalTrials.gov public record
Updated Nov 22, 2021 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional

Cardionomic STOP-ADHF Study

NCT04814134
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
CPNS Therapy, Standard of care
Device · Other
Lead sponsor
Cardionomic Inc.
Industry
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
9
States / cities
Indianapolis, Indiana • Akron, Ohio • Cincinnati, Ohio + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2024 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional

Evaluation of the Safety and Efficacy of the 2-lead OPTIMIZER® Smart System

NCT03339310
View directory record Official record
Conditions
Heart Failure, Congestive Heart Failure, Chronic Heart Disease, CHF
Interventions
Optimizer Smart System with 2-leads
Device
Lead sponsor
Impulse Dynamics
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
9
States / cities
Mesa, Arizona • Phoenix, Arizona • Scottsdale, Arizona + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2020 · Synced Sep 4, 2026, 2:17 AM EDT
Active, not recruiting Not applicable Interventional

Assessment of Combined CCM and ICD Device in HFrEF

NCT05855135
View directory record Official record
Conditions
Heart Failure, Heart Failure With Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation
Interventions
OPTIMIZER® Integra CCM-D System (Treatment Arm)
Device
Lead sponsor
Impulse Dynamics
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
59
States / cities
Glendale, Arizona • Mesa, Arizona • Phoenix, Arizona + 40 more
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Sep 4, 2026, 2:17 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pharmacokinetics of Oxytocin at Cesarean Delivery

NCT03898882
View directory record Official record
Conditions
Postpartum Hemorrhage
Interventions
oxytocin, Shore durometer
Drug · Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 6, 2020 · Synced Sep 4, 2026, 2:17 AM EDT