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ClinicalTrials.gov public records Last synced Oct 22, 2026, 2:06 AM EDT

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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: lung protective ventilation Clear all
Terminated No phase listed Observational Results available

Esophageal Pressure Measurements During One-lung Ventilation

NCT04725318
View directory record Official record
Conditions
Surgery, One-lung Ventilation
Interventions
One-lung ventilation
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 22, 2026, 2:06 AM EDT
Not listed Not applicable Interventional

Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO

NCT04832789
View directory record Official record
Conditions
ARDS
Interventions
Venovenous ECMO
Device
Lead sponsor
University of Toronto
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
2
States / cities
New York, New York • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 6, 2021 · Synced Oct 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional

Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients

NCT00747045
View directory record Official record
Conditions
Chronic Thromboembolic Pulmonary Hypertension, Acute Lung Injury
Interventions
Ventilation Strategy
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Dec 3, 2014 · Synced Oct 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional

Low-Intensity Mechanical Ventilation in the Operating Room: a Pilot Study

NCT07277244
View directory record Official record
Conditions
Robotic Surgery, Post Operative Pulmonary Complications
Interventions
Low Intensity Mechanical Ventilation
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 22, 2026, 2:06 AM EDT
Not listed Not applicable Interventional

Clinical Decision Support for Mechanical Ventilation of Patients With ARDS

NCT03984175
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome
Interventions
Implementation of Processes
Procedure
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Aug 3, 2022 · Synced Oct 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional

Protective Ventilation With High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery

NCT02963025
View directory record Official record
Conditions
One-Lung Ventilation
Interventions
PEEP level, Use of recruitment maneuvers
Procedure
Lead sponsor
Technische Universität Dresden
Other
Eligibility
18 Years and older
Enrollment
2,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
3
States / cities
Boston, Massachusetts • New York, New York • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 26, 2025 · Synced Oct 22, 2026, 2:06 AM EDT
Terminated Not applicable Interventional

The Effects of Different Ventilator Strategies on Inflammation and Injury in Normal Lungs

NCT01003730
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome
Interventions
Ventilator settings
Other
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated May 5, 2015 · Synced Oct 22, 2026, 2:06 AM EDT
Not yet recruiting Not applicable Interventional

Trial of Total Lung Protective Ventilation in Adult VV-ECMO Patients With Severe ARDS

NCT07790133
View directory record Official record
Conditions
ARDS (Acute Respiratory Distress Syndrome), VV ECMO
Interventions
Mechanical Power Targeted Ventilation
Procedure
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional

Adaptive Support Ventilation in Acute Respiratory Distress Syndrome

NCT03715751
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome
Interventions
ASV, Lung Protective Ventilation
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Oct 22, 2026, 2:06 AM EDT
Terminated Not applicable Interventional

Goal of Open Lung Ventilation in Donors

NCT03439995
View directory record Official record
Conditions
Brain Death, Organ Donation, Organ Transplant Failure or Rejection
Interventions
Open lung protective ventilation, Conventional ventilation
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
13 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
4
States / cities
Los Angeles, California • Palo Alto, California • San Francisco, California + 1 more
Source: ClinicalTrials.gov public record
Updated May 6, 2021 · Synced Oct 22, 2026, 2:06 AM EDT
Not listed Not applicable Interventional

Effect of Transpulmonary Pressure Guided Ventilation on Intraoperative Right Heart Function

NCT05709041
View directory record Official record
Conditions
Obesity, Surgery, Anesthesia, Echocardiography, Transesophageal, Mechanical Ventilation
Interventions
Individualized lung-protective ventilation, Standard lung-protective ventilation
Other
Lead sponsor
University of Vermont Medical Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Feb 1, 2023 · Synced Oct 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional Results available

Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study

NCT04663802
View directory record Official record
Conditions
ARDS, Critical Illness, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
Interventions
Default order set, Physician-targeted accountable justification, Respiratory therapist (RT)-targeted accountable justification
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 99 Years
Enrollment
7,342 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Plainsboro, New Jersey • Philadelphia, Pennsylvania • West Chester, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Oct 22, 2026, 2:06 AM EDT
Recruiting Not applicable Interventional

STimulation to Activate RespIration

NCT06832306
View directory record Official record
Conditions
ARDS (Moderate or Severe), AHRF, Mechanically Ventilated ICU Patients
Interventions
Phrenic Nerve Stimulation
Device
Lead sponsor
Lungpacer Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
6
States / cities
La Jolla, California • Shreveport, Louisiana • Winston-Salem, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 22, 2026, 2:06 AM EDT
Withdrawn Not applicable Interventional

Assessment of Occult Lung Stress During Lung Protective Mechanical Ventilation

NCT05675696
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome
Interventions
Esophageal Catheter
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Oct 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional Results available

Laryngeal Mask Airway (LMA) for Surfactant Administration in Neonates

NCT01116921
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
Nasal continuous positive airway pressure (nCPAP), Laryngeal Mask Airway (LMA) to deliver surfactant, Surfactants, Pulmonary
Device · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
Up to 36 Hours
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
7
States / cities
Loma Linda, California • San Diego, California • Maple Grove, Minnesota + 4 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2017 · Synced Oct 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional

Mechanical Power-Guided Lung Protective Ventilation (VentCoach) in Acute Hypoxemic and/or Hypercapnic Respiratory Failure

NCT07294768
View directory record Official record
Conditions
Mechanical Ventilation
Interventions
VentCoach, Standard of Care
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 19, 2025 · Synced Oct 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional

Individualized Perioperative Open Lung Ventilatory Strategy

NCT02158923
View directory record Official record
Conditions
Moderated-high Risk of Postoperative Pulmonary Complication, Abdominal Surgery Expected More Than Two Hours
Interventions
Alveolar recruitment maneuver, Calculation of optimal PEEP, Postoperative CPAP
Procedure
Lead sponsor
Fundación para la Investigación del Hospital Clínico de Valencia
Other
Eligibility
18 Years and older
Enrollment
920 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 17, 2016 · Synced Oct 22, 2026, 2:06 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Comparison Study of High Frequency Percussive Ventilation With Conventional Ventilation

NCT00308022
View directory record Official record
Conditions
Respiratory Distress Syndrome, Adult, Pneumonia, Mechanical Ventilation
Interventions
High Frequency Percussive Ventilation
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 17, 2019 · Synced Oct 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional

Protective Ventilation With Higher Versus Lower PEEP During General Anesthesia for Surgery in Obese Patients

NCT02148692
View directory record Official record
Conditions
Morbid Obesity, Surgery, General Anesthesia
Interventions
Higher PEEP, Lower PEEP
Procedure
Lead sponsor
Technische Universität Dresden
Other
Eligibility
18 Years and older
Enrollment
2,013 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Boston, Massachusetts • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 3, 2019 · Synced Oct 22, 2026, 2:06 AM EDT
Completed No phase listed Observational

Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure

NCT03225807
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, ARDS, Respiratory Distress Syndrome, Acute, Respiratory Insufficiency, Respiratory Distress Syndrome, Shock Lung, Severe Acute Respiratory Syndrome
Interventions
Not listed
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years and older
Enrollment
8,692 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Oct 22, 2026, 2:06 AM EDT
Terminated Not applicable Interventional Results available

BEST (Burn Center Evaluation of Standard Therapies) Ventilator Mode Study-

NCT00351741
View directory record Official record
Conditions
Burns
Interventions
Ventilation - High Frequency Percussive Ventilation, Ventilation - ARDSnet
Device
Lead sponsor
United States Army Institute of Surgical Research
Federal
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 21, 2015 · Synced Oct 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional

PROVHILO:Protective Ventilation During General Anesthesia for Open Abdominal Surgery

NCT01441791
View directory record Official record
Conditions
Postoperative Respiratory Complications
Interventions
Lung protective strategy ventilation
Procedure
Lead sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Other
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
Boston, Massachusetts • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 9, 2014 · Synced Oct 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional Results available

Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distress Syndrome

NCT03793842
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, ARDS
Interventions
Usual care, PEEP titration by EIT
Other · Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 12, 2023 · Synced Oct 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise in Health and Chronic Obstructive Pulmonary Disease

NCT02300064
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Knee-extensor exercise test, Exercise test with restricting/releasing blood flow, Exercise test with variable oxygen concentration and MRI, Exercise test with oral antioxidant or placebo cocktail
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2016
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 1, 2016 · Synced Oct 22, 2026, 2:06 AM EDT