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ClinicalTrials.gov public records Last synced Oct 17, 2026, 10:21 PM EDT

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Showing 193–216 of 230 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: Mclean Hospital Clear all
Completed No phase listed Observational Accepts healthy volunteers

Detecting Drugs of Abuse Via Exhaled Breath Samples Using Differential Mobility Spectrometry

NCT05384470
View directory record Official record
Conditions
Opiate Abuse, Marijuana Abuse, Diagnostic
Interventions
Marihuana, BID2 Instrument - breathalyzer
Drug · Device
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 2, 2025 · Synced Oct 17, 2026, 10:21 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

The Effects of Nicotinamide Riboside Supplementation on Brain NAD+/NADH Ratio and Bioenergetics

NCT03151707
View directory record Official record
Conditions
Healthy
Interventions
Nicotinamide Riboside
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced Oct 17, 2026, 10:21 PM EDT
Terminated Not applicable Interventional

Electrophysiological Correlates of Cognition in Depression

NCT03998748
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Sham Genetic Feedback
Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 19, 2023 · Synced Oct 17, 2026, 10:21 PM EDT
Active, not recruiting Phase 2 Interventional

Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)

NCT04464980
View directory record Official record
Conditions
Opioid Use Disorder (OUD)
Interventions
SL-BUP, XR-BUP, XR-NTX, MM, MMR, MMD
Drug · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
1,516 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
21
States / cities
Little Rock, Arkansas • Tarzana, California • Bridgeport, Connecticut + 17 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 17, 2026, 10:21 PM EDT
Recruiting Not applicable Interventional

Individually Targeted Neuromodulation for Contamination-based OCD

NCT05048251
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
cTBS, iTBS, sham
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 15, 2024 · Synced Oct 17, 2026, 10:21 PM EDT
Recruiting Phase 2Phase 3 Interventional

MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction

NCT06191965
View directory record Official record
Conditions
Schizophrenia and Related Disorders, Mitochondrial Alteration, Cognitive Impairment
Interventions
MitoQ, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
New Haven, Connecticut • Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Oct 17, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot Study

NCT05380583
View directory record Official record
Conditions
Psychosis, Substance Use, Substance Use Disorders, Family, Cannabis, Marijuana, Alcohol, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Mental Disorder
Interventions
CRAFT-EP, TAU
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 17, 2026, 10:21 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Transdermal Electroacupuncture for Opioid Detoxification

NCT00742170
View directory record Official record
Conditions
Opioid Dependency
Interventions
Electroacupuncture
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 59 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2014 · Synced Oct 17, 2026, 10:21 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Depression and Dopamine Transporter Function Study Using C-11 Altropane

NCT01701141
View directory record Official record
Conditions
Major Depressive Disorder, Anhedonia
Interventions
Not listed
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
2
States / cities
Belmont, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Oct 17, 2026, 10:21 PM EDT
Completed Not applicable Interventional

Women's Opioid Treatment Follow-up Study

NCT05776966
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Gender-specific digital intervention (GSDI), Treatment as usual
Behavioral · Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 17, 2026, 10:21 PM EDT
Completed Not applicable Interventional Results available

Women's Recovery Group (WRG) Study - A Randomized Controlled Stage II Trial

NCT01318538
View directory record Official record
Conditions
Substance-Related Disorders, Alcohol-Related Disorders
Interventions
The Women's Recovery Group, Group Drug Counseling
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
2
States / cities
Belmont, Massachusetts • Fall River, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 5, 2017 · Synced Oct 17, 2026, 10:21 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

IV Nicotine Induced Changes in Hormone Function, Mood States and Behavior

NCT01589055
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Intravenous Nicotine
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 40 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2015
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2024 · Synced Oct 17, 2026, 10:21 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Effects of Progesterone on IV Nicotine Induced Changes on BOLD fMRI Signal, Hormones and Subjective Ratings of Stimulant Drugs

NCT01589068
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Intravenous Nicotine, Progesterone
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 40 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2015
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2024 · Synced Oct 17, 2026, 10:21 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

An Investigation of Early Life Stress and Depression

NCT01701258
View directory record Official record
Conditions
Major Depressive Disorder (MDD), History of Childhood Sexual Abuse (CSA)
Interventions
Amisulpride, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
20 Years to 45 Years · Female only
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
2
States / cities
Belmont, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Oct 17, 2026, 10:21 PM EDT
Completed Early Phase 1 Interventional

Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia

NCT04430517
View directory record Official record
Conditions
Mild Cognitive Impairment, Mild Alzheimer Disease
Interventions
Nicotinamide riboside
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
55 Years to 89 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 17, 2026, 10:21 PM EDT
Completed Not applicable Interventional

Efficacy And Safety Of An Innovative Treatment Of Opiate Use Disorders

NCT04340622
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Dependence, Opioid Abuse
Interventions
supra-luminous LED, Sham
Device
Lead sponsor
MindLight, LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
Belmont, Massachusetts • Newton Highlands, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Oct 17, 2026, 10:21 PM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T

NCT01747590
View directory record Official record
Conditions
Psychotropic Drugs Effects
Interventions
Zolpidem, Alprazolam, Caffeine, Placebo
Drug · Other
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 40 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 11, 2012 · Synced Oct 17, 2026, 10:21 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study of Brain Circuitry in Anxiety Disorders

NCT01849432
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Panic Disorder, Specific Phobias
Interventions
Not listed
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 8, 2013 · Synced Oct 17, 2026, 10:21 PM EDT
Terminated No phase listed Observational

Treximet Migraine Brain Imaging Research Study

NCT01112553
View directory record Official record
Conditions
Acute Migraine
Interventions
Not listed
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 1, 2012 · Synced Oct 17, 2026, 10:21 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Non-Steroidal Anti-Inflammatory Drug (NSAID) Response and Central Sensitization of Pain in Women With Dysmenorrhea

NCT05900336
View directory record Official record
Conditions
Dysmenorrhea, Menstrual Pain, Non-steroidal Anti-inflammatory Drug
Interventions
Sodium Naproxen, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 17, 2026, 10:21 PM EDT
Active, not recruiting Phase 2 Interventional

Evaluating the Impact of a Novel Cannabinoid Product for Endometriosis

NCT06477406
View directory record Official record
Conditions
Endometriosis
Interventions
Cannabidiol, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 17, 2026, 10:21 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders

NCT03943537
View directory record Official record
Conditions
Psychosis, Schizophrenia, Schizo Affective Disorder, Bipolar I Disorder
Interventions
Intranasal Insulin
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 40 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 17, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels

NCT01588561
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Intravenous Nicotine, Saline - placebo
Drug · Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 40 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2015
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 17, 2026, 10:21 PM EDT
Terminated Phase 3 Interventional

Low Field Magnetic Stimulation Treatment for Bipolar Depression

NCT00217217
View directory record Official record
Conditions
Bipolar Depression, Bipolar Disorder, Depression
Interventions
Echo-Planar Magnetic Resonance Imaging (EP-MRSI)
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 14, 2012 · Synced Oct 17, 2026, 10:21 PM EDT