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Conditions: Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection, Hemolytic-Uremic Syndrome
Interventions: Infusion of 200% maintenance fluids as balanced crystalloid IV solution, Oral fluids; infusion of up to 110% maintenance fluids as balanced crystalloid IV solution; Other
Lead sponsor: University of Calgary; Other
Eligibility: 9 Months to 21 Years
Enrollment: 1,040 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2028
U.S. locations: 22
States / cities: Birmingham, Alabama • Little Rock, Arkansas • La Jolla, California + 19 more

Conditions: Respiratory Insufficiency of Prematurity
Interventions: Titration of oxygen therapy; Other
Lead sponsor: McMaster University; Other
Eligibility: Up to 24 Hours
Enrollment: 1,201 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 3
States / cities: Stony Brook, New York • Philadelphia, Pennsylvania

Conditions: Late-Onset Neonatal Sepsis, Extreme Prematurity, Neonatal Hypotension
Interventions: Dopamine, Norepinephrine; Drug
Lead sponsor: Mount Sinai Hospital, Canada; Other
Eligibility: 21 Weeks to 32 Weeks
Enrollment: 550 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 3
States / cities: Phoenix, Arizona • Dayton, Ohio • San Antonio, Texas

Conditions: Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring, Fragility Fracture, Internal Fixation, Nonoperative Care
Interventions: Early Internal Fixation, Nonoperative Care with Early Rehabilitation; Procedure · Other
Lead sponsor: University of Southern California; Other
Eligibility: 60 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 12
States / cities: Phoenix, Arizona • Los Angeles, California • Sacramento, California + 7 more

Conditions: Corona Virus Infection, Covid19, COVID-19
Interventions: Awake Proning; Procedure
Lead sponsor: St. Joseph's Healthcare Hamilton; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Tibial Fractures
Interventions: Exogen 4000+, Sham; Device
Lead sponsor: Bioventus LLC; Industry
Eligibility: 18 Years and older
Enrollment: 501 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 13
States / cities: San Francisco, California • Tampa, Florida • Indianapolis, Indiana + 9 more

Conditions: Alcohol Use Disorder
Interventions: Episodic Future Thinking, Control Episodic Thinking; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: GERD, Hiatal Hernia, Heartburn, Paraesophageal Hernia, Gastroesophageal Reflux
Interventions: Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry; Procedure
Lead sponsor: McMaster University; Other
Eligibility: 18 Years and older
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Respiratory Insufficiency of Prematurity
Interventions: nCPAP, NIPPV; Device
Lead sponsor: McMaster University; Other
Eligibility: Up to 28 Days
Enrollment: 1,011 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 14
States / cities: Washington D.C., District of Columbia • Boston, Massachusetts • Voorhees Township, New Jersey + 6 more

Conditions: Hip Fractures
Interventions: Accelerated medical clearance and surgery; Other
Lead sponsor: McMaster University; Other
Eligibility: 45 Years and older
Enrollment: 3,001 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2022
U.S. locations: 5
States / cities: San Jose, California • Baltimore, Maryland • Burlington, Massachusetts + 2 more

Conditions: Instructional Methods
Interventions: Conceptual teaching; Other
Lead sponsor: Sentara Norfolk General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 65 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Norfolk, Virginia

Conditions: Gastric Cancer
Interventions: Roux-en-Y pouch reconstruction (RYP), conventional Roux-en-Y reconstruction (RYC); Procedure
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Acute Respiratory Distress Syndrome (ARDS)
Interventions: SensorMedics 3100B High Frequency Oscillatory Ventilator, Lung Protective Ventilation; Device · Procedure
Lead sponsor: Canadian Critical Care Trials Group; Other
Eligibility: 16 Years to 85 Years
Enrollment: 548 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 8
States / cities: Denver, Colorado • Orlando, Florida • Ann Arbor, Michigan + 5 more

Conditions: Atrial Fibrillation (AF), VTE
Interventions: PAUSE Perioperative DOAC Management, ASRA Perioperative DOAC Management; Other
Lead sponsor: McMaster University; Other
Eligibility: 18 Years and older
Enrollment: 920 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 6
States / cities: Hartford, Connecticut • Evanston, Illinois • Boston, Massachusetts + 3 more

Conditions: Coagulation, Bleeding, Thrombosis
Interventions: Phytonadione (Vitamin K1); Drug
Lead sponsor: St. Joseph's Healthcare Hamilton; Other
Eligibility: 18 Years and older
Enrollment: 690 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 2
States / cities: Westminster, Colorado • Albuquerque, New Mexico

Conditions: Femoral Neck Fractures
Interventions: Hip arthroplasty, Internal fixation; Procedure
Lead sponsor: University of Southern California; Other
Eligibility: 60 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 20
States / cities: Irvine, California • Los Angeles, California • Miami, Florida + 15 more

Conditions: Intensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory Failure
Interventions: In-bed cycle ergometer (Restorative Therapies RT300 Supine), Routine physiotherapy; Device · Other
Lead sponsor: McMaster University; Other
Eligibility: 18 Years and older
Enrollment: 113 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Breast Cancer, Breast Surgery, Breast Reconstruction, Breast Reduction, Breast Augmentation
Interventions: questionnaires; Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years to 85 Years
Enrollment: 722 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2013
U.S. locations: 4
States / cities: Baltimore, Maryland • Lebanon, New Hampshire • New York, New York + 1 more

Conditions: Breast Cancer
Interventions: qualitative interviews with patients, questionnaires; Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Spinal Cord Injuries, Trauma, Nervous System
Interventions: MyndMove®, Conventional Therapy; Device · Other
Lead sponsor: MyndTec Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 2
States / cities: Cleveland, Ohio • Houston, Texas

Conditions: Acute Lymphoblastic Leukemia
Interventions: prednisone, dexamethasone, doxorubicin, E. coli asparaginase, vincristine, methotrexate, Leucovorin, Asparaginase, cytarabine, Methotrexate/Hydrocortisone; Drug
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 1 Year to 18 Years
Enrollment: 498 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2011
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Critical Illness, Deep Venous Thrombosis
Interventions: LMWH (Fragmin, dalteparin), Unfractionated Heparin; Drug
Lead sponsor: McMaster University; Other
Eligibility: 18 Years and older
Enrollment: 3,659 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 4
States / cities: Rochester, Minnesota • St Louis, Missouri • Providence, Rhode Island + 1 more

Conditions: Metastatic Bone Disease
Interventions: Internal Fixation, Resection and reconstruction; Procedure
Lead sponsor: Michelle Ghert, MD; Other
Eligibility: 18 Years and older
Enrollment: 334 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 7
States / cities: Aurora, Colorado • Fort Wayne, Indiana • Baltimore, Maryland + 4 more

Conditions: Breast Cancer
Interventions: counseling intervention, questionnaire administration, psychosocial assessment and care, quality-of-life assessment; Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 357 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2023
U.S. locations: 2
States / cities: New York, New York

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Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

Canadian Oxygen Trial (COT)

Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis

Early Internal Fixation Versus NonOperative Care With Early Rehabilitation for LC1 Fragility Fractures of the Pelvis

Awake Prone Position in Hypoxemic Patients With Coronavirus Disease 19 COVID-19 (COVI-PRONE)

Trial to Evaluate UltraSound in the Treatment of Tibial Fractures

Increasing the Temporal Window in Individuals With Alcohol Use Disorder

Antireflux Surgery Without Preoperative Esophageal Manometry

Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)

HIP Fracture Accelerated Surgical TreaTment And Care tracK (HIP ATTACK) Trial

A Study to Evaluate Strategies for Teaching Effective Use of Diagnostic Tests

Impact of Roux-En-Y Pouch Reconstruction Compared With Conventional Roux-En-Y Reconstruction on Health-Related Quality of Life in Patients Undergoing Total Gastrectomy for Adenocarcinoma

The Oscillation for Acute Respiratory Distress Syndrome (ARDS) Treated Early (OSCILLATE) Trial

Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure

Oral Vitamin K for Warfarin Associated Coagulopathy

MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

CYCLE Pilot Randomized Trial

Measuring Patient Satisfaction and Quality of Life Following Body Image Altering Surgery

Developing a New Questionnaire About Patient Expectations of Breast Conserving Therapy

Restoration of Reaching and Grasping Function in Individuals With Spinal Cord Injury Using MyndMove® Neuromodulation Therapy

Treatment of Acute Lymphoblastic Leukemia in Children

PROphylaxis for ThromboEmbolism in Critical Care Trial (PROTECT)

Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Trial

Development of a Questionnaire to Evaluate Patient Expectations for Breast Reconstruction in Women With Breast Cancer or Other Conditions