Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Sep 29, 2026, 7:01 PM EDT

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Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Femoral Arterial Calcification, Peripheral Arterial Disease, Claudication, Critical Limb Ischemia
Interventions
Shockwave Intravascular Lithotripsy (IVL)
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
New Haven, Connecticut • Providence, Rhode Island
Conditions
Coronary Artery Disease, Myocardial Infarction
Interventions
IVL with Shockwave C2+ 2Hz Coronary IVL Catheter
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
18
States / cities
Huntsville, Alabama • La Jolla, California • Washington D.C., District of Columbia + 15 more
Completed Not applicable Interventional Results available

Disrupt CAD III With the Shockwave Coronary IVL System

NCT03595176
Conditions
Coronary Artery Disease, Myocardial Infarction
Interventions
Lithotripsy
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
Not listed
Enrollment
431 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
39
States / cities
Scottsdale, Arizona • La Jolla, California • Orange, California + 32 more
Conditions
Refractory Angina
Interventions
Arm 1: treatment with Shockwave Reducer, Arm 2 (control): Implantation procedure with no device implanted, Arm 3 (unblinded, non-randomized): Single arm registry
Device · Other
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
380 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2032
U.S. locations
71
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Tucson, Arizona + 56 more
Completed Not applicable Interventional Results available

Disrupt PAD BTK II Study With the Shockwave Peripheral IVL System

NCT05007925
Conditions
Peripheral Artery Disease
Interventions
Intravascular Lithotripsy
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
39
States / cities
Fresno, California • La Jolla, California • Los Angeles, California + 33 more
Conditions
Iliac Disease, Aortic Valve Stenosis
Interventions
Shockwave Balloon
Device
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Plano, Texas
Conditions
Aortic Stenosis
Interventions
Shockwave M5 IVL Catheter, Modified Seldinger Technique
Device · Procedure
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Knoxville, Tennessee
Recruiting Not applicable Interventional

FORWARD CAD IDE Study

NCT06662500
Conditions
Coronary Arterial Disease (CAD)
Interventions
Intravascular Lithotripsy
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
408 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
28
States / cities
La Jolla, California • San Francisco, California • Littleton, Colorado + 19 more
Conditions
Peripheral Arterial Disease, Vascular Disease, Peripheral
Interventions
Shockwave Medical M5+ Peripheral Intravascular Lithotripsy (IVL)
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
3
States / cities
Davenport, Iowa • Raleigh, North Carolina • Bartlesville, Oklahoma
Conditions
Coronary Artery Disease
Interventions
Shockwave Medical Coronary IVL System
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
399 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
34
States / cities
Loma Linda, California • Los Angeles, California • San Francisco, California + 26 more
Withdrawn No phase listed Observational

Shockwave: Disruption for A Better Fit

NCT05147363
Conditions
Peripheral Arterial Disease
Interventions
Shockwave Intravenous lithotripsy with a Supera stent
Device
Lead sponsor
Cardiovascular Institute of the South Clinical Research Corporation
Other
Eligibility
18 Years and older
Timeline
2020 – 2022
U.S. locations
1
States / cities
Houma, Louisiana
Conditions
Carotid Artery Calcification, Carotid Artery Diseases
Interventions
Carotid Intravascular Lithotripsy
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
25
States / cities
Scottsdale, Arizona • Aurora, Colorado • Jacksonville, Florida + 19 more
Conditions
Heart Failure Preserved Ejection Fraction
Interventions
Coronary Sinus Reducer
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Completed No phase listed Observational

DISRUPT PAD III Observational Study

NCT05881421
Conditions
Peripheral Arterial Disease
Interventions
Not listed
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,373 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
26
States / cities
Palo Alto, California • Aurora, Colorado • Loveland, Colorado + 22 more
Conditions
Mitral Valve Regurgitation
Interventions
Mitral valve replacement
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
6
States / cities
Los Angeles, California • Chicago, Illinois • Detroit, Michigan + 3 more
Conditions
Angioplasty
Interventions
Metricath Gemini System
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
Not listed
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
10
States / cities
Orange, California • Sacramento, California • Hudson, Florida + 7 more
Conditions
Peripheral Arterial Disease
Interventions
Shockwave Lithoplasty® Peripheral Lithoplasty System, Medtronic IN.PACT (DCB)
Device · Drug
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
40
States / cities
Little Rock, Arkansas • Palo Alto, California • Aurora, Colorado + 33 more
Withdrawn Not applicable Interventional

Shockwave Assisted Large Bore Access

NCT04600934
Conditions
Vascular Diseases
Interventions
Shockwave, Plain old balloon angioplasty
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Coronary Artery Disease, CT
Interventions
CT-guided PCI, Routine PCI
Procedure
Lead sponsor
Minneapolis Heart Institute Foundation
Other
Eligibility
22 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Completed No phase listed Observational Results available

Disrupt CAD III Post-Approval Study (PAS)

NCT05021757
Conditions
Coronary Artery Disease, Myocardial Infarction
Interventions
Shockwave C2 Coronary IVL
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Completed Not applicable Interventional Results available

FORWARD PAD IDE Study With the Shockwave Javelin IVL Catheter

NCT05858905
Conditions
Peripheral Arterial Disease
Interventions
Intravascular Lithotripsy
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
21
States / cities
Palo Alto, California • Thornton, Colorado • Bradenton, Florida + 18 more
Conditions
Carotid Artery Calcification, Carotid Artery Diseases
Interventions
Carotid Intravascular Lithotripsy (IVL)
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
25
States / cities
Little Rock, Arkansas • Rancho Mirage, California • Sacramento, California + 20 more