VTX002 Versus Placebo for the Treatment of Moderately to Severely Active Ulcerative Colitis
Public ClinicalTrials.gov record NCT05156125. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Clinical Efficacy and Safety of VTX002 in Subjects With Moderately to Severely Active Ulcerative Colitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a study to understand if taking VTX002 daily as a tablet orally is safe and effective in participants diagnosed with moderate to severe ulcerative colitis (UC). Approximately 189 participants will take VTX002 Dose A, VTX002 Dose B, or matching placebo, once daily. The study consists of a 28-day Screening Period (to see if a participant qualifies for the study), a 13-week double-blind period (a participant receives either active Dose A, Dose B or Placebo), a Long-Term Extension (LTE) Treatment Period of up to 39 weeks, an Open-Label Extension (OLE) Treatment Period of up to 143 weeks, and a 2-week Follow-Up Period. The maximal duration of treatment including the Induction Period, LTE and OLE will be 36 months.
Study identification
- NCT ID
- NCT05156125
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 213 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 30, 2021 (Actual)
- Primary completion
- Aug 30, 2023 (Actual)
- Completion
- Mar 13, 2025 (Actual)
- Last update posted
- Apr 30, 2026
2021 – 2025
United States locations
- U.S. sites
- 19
- U.S. states
- 10
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Site # 840030 | Garden Grove | California | 92845 | — |
| Local Site # 840026 | Lancaster | California | 93534 | — |
| Local Site # 840040 | San Diego | California | 92123 | — |
| Local Site # 840001 | Ventura | California | 93003 | — |
| Local Site # 840049 | Kissimmee | Florida | 34744 | — |
| Local Site # 840006 | Miami | Florida | 33165 | — |
| Local Site # 840018 | Atlanta | Georgia | 30342 | — |
| Local Site # 840046 | New Albany | Indiana | 47150 | — |
| Local Site # 840042 | Shreveport | Louisiana | 71105 | — |
| Local Site # 840044 | Ypsilanti | Michigan | 48197 | — |
| Local Site # 840043 | Dayton | Ohio | 45415 | — |
| Local Site # 840010 | Oklahoma City | Oklahoma | 73101 | — |
| Local Site # 840045 | Myrtle Beach | South Carolina | 29572 | — |
| Local Site # 840013 | Garland | Texas | 75044 | — |
| Local Site # 8400039 | Lubbock | Texas | 79424 | — |
| Local Site # 840033 | McAllen | Texas | 78503 | — |
| Local Site # 840007 | San Marcos | Texas | 78666 | — |
| Local Site # 840016 | Southlake | Texas | 76092 | — |
| Local Site # 840028 | Tyler | Texas | 75701 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 58 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05156125, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 30, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05156125 live on ClinicalTrials.gov.