Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 3, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 3, 2026, 5:17 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 13–24 of 2,941 matching trials for Depression.

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Conditions: Major Depressive Disorder
Interventions: Motif XCS System; Device
Lead sponsor: Motif Neurotech, Inc.; Industry
Eligibility: 22 Years to 85 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Atlanta, Georgia • Iowa City, Iowa

Conditions: Bipolar Disorder, Major Depression, Schizophrenia
Interventions: Transition-FOCUS mHealth Intervention, Check-In; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years and older
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Major Depressive Disorder
Interventions: Neuronavigated rTMS, sham rTMS; Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Stanford, California

Conditions: Major Depressive Disorder
Interventions: FMRI with sham controlled feedback, FMRI with real time feedback; Other
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 55 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Major Depressive Disorder (MDD)
Interventions: Adalimumab Biosimilars Injection, Placebo; Drug · Other
Lead sponsor: Daniel Moriarity; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Major Depressive Disorder
Interventions: CYB003, Psychological Support, Placebo; Drug · Behavioral
Lead sponsor: Cybin IRL Limited; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 220 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 45
States / cities: Phoenix, Arizona • Tucson, Arizona • Bellflower, California + 35 more

Conditions: Antenatal Depression, Major Depressive Disorder, Major Depressive Disorder in Pregnancy, Healthy Controls
Interventions: tACS (aperiodic); Device
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 6 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Major Depressive Disorder
Interventions: Baricitinib, Placebo; Drug
Lead sponsor: Emory University; Other
Eligibility: 25 Years to 55 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Parkinson's Disease, Depression
Interventions: Cognitive Behavior Therapy (CBT), Treatment As Usual (TAU); Other
Lead sponsor: Yale University; Other
Eligibility: 40 Years to 80 Years
Enrollment: 49 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Depression, Parkinson's Disease (PD)
Interventions: Psilocybin (drug); Drug
Lead sponsor: Yale University; Other
Eligibility: 40 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Depression
Interventions: Growth Mindset; Behavioral
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 11 Years to 25 Years
Enrollment: 4,100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2027
U.S. locations: 3
States / cities: Los Angeles, California • Denver, Colorado • Bethesda, Maryland

Conditions: Opioid Use Disorder, Major Depressive Disorder (MDD)
Interventions: Transcranial Magnetic Stimulation (TMS), Sham Transcranial Magnetic Stimulation (TMS); Device
Lead sponsor: University of Kentucky; Other
Eligibility: 18 Years to 75 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Lexington, Kentucky

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

Filter and sort this condition

Live official records

Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium

Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness

Closed-loop Optimized rTMS for Depression

Targeting Large-scale Networks in Depression With Real-time Functional Magnetic Resonance Imaging (fMRI) Neurofeedback

Precision Depression Adalimumab Trial

"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)

JAK Signaling in Depression

Long Term Follow Up KET-PD

The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease

Characterization and Treatment of Adolescent Depression

Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation

About this Depression clinical trials directory page