Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 26, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 26, 2026, 2:59 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 313–324 of 5,328 matching trials for Depression.

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Live official records

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Conditions: Depression
Interventions: Heated Yoga, Non-Heated Yoga; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Cambridge, Massachusetts

Conditions: Treatment Resistant Depression
Interventions: BPL-003; Drug
Lead sponsor: Beckley Psytech Limited; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 196 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 19
States / cities: Birmingham, Alabama • Rogers, Arkansas • San Diego, California + 15 more

Conditions: HIV, Depression, Anxiety
Interventions: PositiveLinks with Counseling, Standard of Care (SOC); Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 90 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Treatment Resistant Depression
Interventions: Propofol; Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 55 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Major Depressive Disorder (MDD)
Interventions: Rejoyn, Cognitive Behavioral Therapy (CBT) exercises; Device · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 22 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Greenwich, Connecticut • New Haven, Connecticut

Conditions: Anxiety, Depression
Interventions: Growth, Empowerment, and Mindfulness (GEM); Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 24 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Interoceptive Awareness, Interoception, Alexithymia, Anxiety, Depression Disorders
Interventions: Heart rate feedback from smartwatch; Device
Lead sponsor: Massachusetts Institute of Technology; Other
Eligibility: 18 Years to 65 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Depression, Major Depressive Disorder (MDD), Depression - Major Depressive Disorder, Persistent Depressive Disorder, PDD, MDD
Interventions: Active Repetitive Transcranial Magnetic Stimulation (rTMS), Sham Transcranial Magnetic Stimulation (TMS); Device
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Suicidal, Suicidal Ideation, Suicidal Ideation and Behavior, Depression / Major Depressive Disorder
Interventions: Ketamine (0.5 mg/kg); Drug
Lead sponsor: Endeavor Health; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Evanston, Illinois

Conditions: Major Depressive Episode
Interventions: Diadem prototype; Device
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 65 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Posttraumatic Stress Disorder, Depression
Interventions: Trauma Resilience and Recovery Program; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 16 Years and older
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Washington, Virginia

Conditions: Major Depressive Disorder (MDD)
Interventions: Conversational AI system vs Usual Care; Other
Lead sponsor: George Mason University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Fairfax, Virginia

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

Filter and sort this condition

Live official records

Researching Heat and Yoga for Mood Enhancement

BPL-003 Efficacy and Safety in Treatment Resistant Depression

A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression

Neural and Antidepressant Effects of Propofol

REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness

Growth, Empowerment, and Mindfulness (GEM): A Mindfulness-based Intervention to Address Mental Health in Young Adults With Early Life Adversity

Haptic Feedback for Improved Interoceptive Awareness and Mental Well-being

Individualized fMRI-guided TMS for Depression

Intramuscular Ketamine for Suicidal Patients in the Evanston Hospital Emergency Department for Suicidal Distress

Personalized Ultrasonic Brain Stimulation for Depression

Testing a Scalable Model of Care to Improve Patients Access to Mental Health Services After Traumatic Injury

Evaluating Conversational Artificial Intelligence for Depression Management

About this Depression clinical trials directory page