Condition Directory

Hypertension clinical trials

Directory of U.S. ClinicalTrials.gov public records for Hypertension. Browse Hypertension recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced November 7, 2026 Report an issue

ClinicalTrials.gov public records Last synced Nov 7, 2026, 1:33 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

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How Hypertension studies are organized in the registry

“Hypertension” searches also surface pulmonary hypertension — a different disease with its own research community — so watch for “pulmonary” in titles when scanning results. The blood-pressure portfolio itself includes a high share of behavioral, dietary, and device studies alongside medication trials.

Terms that often appear in related listings

blood pressure resistant hypertension pulmonary hypertension renal denervation

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 1129–1140 of 3,919 matching trials for Hypertension.

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Conditions: Pulmonary Arterial Hypertension
Interventions: Noninvasive actigraphy monitor; Other
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 70 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Pulmonary Arterial Hypertension
Interventions: Not listed
Lead sponsor: Actelion; Industry
Eligibility: 18 Years to 99 Years
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 84
States / cities: Mobile, Alabama • Phoenix, Arizona • Tucson, Arizona + 65 more

Conditions: Portopulmonary Hypertension
Interventions: Macitentan, Placebo; Drug · Other
Lead sponsor: Actelion; Industry
Eligibility: 18 Years and older
Enrollment: 85 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 29
States / cities: Phoenix, Arizona • La Jolla, California • Los Angeles, California + 23 more

Conditions: Pulmonary Arterial Hypertension
Interventions: Opsumit (macitentan); Drug
Lead sponsor: Actelion; Industry
Eligibility: Not listed
Enrollment: 2,686 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 144
States / cities: Mobile, Alabama • Phoenix, Arizona • Fullerton, California + 117 more

Conditions: Pulmonary Arterial Hypertension
Interventions: ACT-293987; Drug
Lead sponsor: Actelion; Industry
Eligibility: 18 Years and older
Enrollment: 709 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2021
U.S. locations: 45
States / cities: Mobile, Alabama • Phoenix, Arizona • Tucson, Arizona + 42 more

Conditions: Pulmonary Arterial Hypertension
Interventions: Notapplicable; Other
Lead sponsor: Actelion; Industry
Eligibility: Not listed
Enrollment: 2,200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 105
States / cities: Phoenix, Arizona • La Jolla, California • Loma Linda, California + 89 more

Conditions: Pulmonary Hypertension
Interventions: Macitentan 10mg, Placebo sugar pill; Drug
Lead sponsor: Actelion; Industry
Eligibility: 18 Years and older
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 50
States / cities: Phoenix, Arizona • Tucson, Arizona • Beverly Hills, California + 42 more

Conditions: Hypertension, Vascular Diseases, Cardiovascular Diseases
Interventions: Symplicity Spyral™ multi-electrode renal denervation system, Sham Procedure; Device · Procedure
Lead sponsor: Medtronic Vascular; Industry
Eligibility: 20 Years to 80 Years
Enrollment: 366 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2023
U.S. locations: 30
States / cities: Huntsville, Alabama • Scottsdale, Arizona • Los Angeles, California + 26 more

Conditions: Hypertension
Interventions: TUDCA, Placebo; Drug
Lead sponsor: University of North Texas Health Science Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Fort Worth, Texas

Conditions: Glaucoma, Primary Open Angle, Ocular Hypertension
Interventions: WB007 0.05%, WB007 0.15%, WB007 0.4%, Timolol 0.5%; Drug
Lead sponsor: Bausch & Lomb Incorporated; Industry
Eligibility: 18 Years and older
Enrollment: 77 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Newport Beach, California

Conditions: Stroke, Acute Ischemic, Hypertension
Interventions: Social Network Group Counseling, Individual Counseling; Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 21 Years and older
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: HIV, Hypertension, Exercise
Interventions: Exercise; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 50 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Birmingham, Alabama

About this Hypertension clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Hypertension as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Hypertension.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Hypertension clinical trials

How Hypertension studies are organized in the registry

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Live official records

HRV as a Marker of Treatment Response in PAH Arterial Hypertension

A Registry for Patients Taking Uptravi

PORtopulmonary Hypertension Treatment wIth maCitentan - a randOmized Clinical Trial

OPsumit USers Registry

ACT-293987 in Pulmonary Arterial Hypertension

Retrospective Chart Review of First-time Opsumit® (Macitentan) Users in the United States

Clinical Study to Assess the Efficacy and Safety of Macitentan in Patients With Pulmonary Hypertension After Left Ventricular Assist Device Implantation

SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study

Targeting Endoplasmic Reticulum Stress in Human Hypertension

Safety and IOP-Lowering Effects of WB007

TEAMS-BP (The Enhancement of Social Networks to Augment Management of Stroke-Blood Pressure)

Feasibility of HIIT in Older Adults with HIV and Hypertension

About this Hypertension clinical trials directory page