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ClinicalTrials.gov public records Last synced Oct 4, 2026, 10:10 AM EDT

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Showing 25–48 of 459 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Acute Cerebrovascular Disease Clear all
Recruiting Phase 2Phase 3 Interventional

Transnasal Sphenopalatine Ganglion Block for Treatment of Acute Subarachnoid Hemorrhage Associated Headache

NCT06621329
View directory record Official record
Conditions
SAH (Subarachnoid Hemorrhage), Headache
Interventions
Transnasal sphenopalatine ganglion block
Combination Product
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 100 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Bioness Integrated Therapy System (BITS) Touch Screen Technology to Improve Field Awareness

NCT04930822
View directory record Official record
Conditions
Stroke, Neurologic Disorder, Traumatic Brain Injury, Acquired Brain Injury
Interventions
Table Top Visual Intervention, Bioness Integrated Therapy System Visual Intervention
Other · Device
Lead sponsor
Gaylord Hospital, Inc
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Wallingford, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Oct 4, 2026, 10:10 AM EDT
Terminated Phase 2 Interventional

The Stroke Warning Information and Faster Treatment Study (SWIFT)

NCT00415389
View directory record Official record
Conditions
Stroke
Interventions
interactive educational program, usual medical care
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
1,635 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 18, 2013 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Phase 3 Interventional Results available

Multi-arm Optimization of Stroke Thrombolysis

NCT03735979
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Argatroban, Eptifibatide, Placebo
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
514 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
61
States / cities
Birmingham, Alabama • Fullerton, California • La Jolla, California + 47 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2025 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Phase 1 Interventional Results available

Antihypertensive Treatment in Acute Cerebral Hemorrhage

NCT00415610
View directory record Official record
Conditions
Intracerebral Hemorrhage, Hypertension, Stroke
Interventions
nicardipine
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
12
States / cities
Los Angeles, California • Kansas City, Kansas • Boston, Massachusetts + 8 more
Source: ClinicalTrials.gov public record
Updated Nov 21, 2017 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Not applicable Interventional Results available

Solitaire™ With the Intention For Thrombectomy as PRIMary Endovascular Treatment (SWIFT PRIME) Trial

NCT01657461
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Intravenous (IV) recombinant human tissue plasminogen activator (rtPA), Solitaire revascularization device
Drug · Device
Lead sponsor
Medtronic Neurovascular Clinical Affairs
Industry
Eligibility
18 Years to 80 Years
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 18, 2017 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Not applicable Interventional

Discharge Educational Strategies for Reduction of Vascular Events

NCT01836354
View directory record Official record
Conditions
Intracerebral Infarcts, Ischemic Stroke, Hemorrhagic Strokes, TIA's
Interventions
DESERVE education
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
552 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
3
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 17, 2020 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Not applicable Interventional Results available

CO-OPerative Training for Stroke Rehabilitation

NCT02755805
View directory record Official record
Conditions
CO-OP, Attention Control
Interventions
CO-OP, Attention Control
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 4, 2026, 10:10 AM EDT
Terminated Phase 2 Interventional Results available

Study of NTx®-265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients

NCT00938314
View directory record Official record
Conditions
Stroke
Interventions
human chorionic gonadotropin (hCG), then epoetin alfa (EPO), Saline Placebo
Drug
Lead sponsor
Stem Cell Therapeutics Corp.
Industry
Eligibility
18 Years to 85 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Nov 29, 2011 · Synced Oct 4, 2026, 10:10 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

A Feasibility Study for Randomization of Code Stroke Imaging Strategies

NCT06270927
View directory record Official record
Conditions
Brain Ischemia
Interventions
MRI, CT
Diagnostic Test
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 120 Years
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Phase 2 Interventional Results available

Glucose Regulation in Acute Stroke Patients (GRASP) Study

NCT00282867
View directory record Official record
Conditions
Stroke, Hyperglycemia
Interventions
IV glucose insulin and potassium, GIK, standard care
Drug · Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Augusta, Georgia • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 21, 2009 · Synced Oct 4, 2026, 10:10 AM EDT
Recruiting Phase 4 Interventional

SUMMIT RISE Study of Acute Ischemic Stroke Patients

NCT07436156
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Route 92 Medical Reperfusion Systems
Device
Lead sponsor
Route 92 Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
West Jordan, Utah
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 4, 2026, 10:10 AM EDT
Terminated Phase 3 Interventional

Phase 3, Randomized, Placebo-Controlled, Double-Blinded Trial of the Combined Lysis of Thrombus With Ultrasound and Systemic Tissue Plasminogen Activator (tPA) for Emergent Revascularization in Acute Ischemic Stroke

NCT01098981
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Transcranial ultrasound as an adjunctive therapy to tPA, Standard of care tPA therapy for acute ischemic stroke
Device · Drug
Lead sponsor
Cerevast Therapeutics, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
675 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Redmond, Washington
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Phase 2 Interventional Results available

Histamine Glutamate Antagonism in Stroke

NCT02142712
View directory record Official record
Conditions
Acute Cerebrovascular Accident, Cerebral Edema
Interventions
Diphenhydramine, Pantoprazole, Famotidine, Dextromethorphan
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 15, 2015 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Phase 3 Interventional

Study of Desmoteplase (International Nonproprietary Name [INN]) in Acute Ischemic Stroke (DIAS-2)

NCT00111852
View directory record Official record
Conditions
Stroke, Acute
Interventions
Desmoteplase, Placebo
Drug
Lead sponsor
Forest Laboratories
Industry
Eligibility
18 Years to 85 Years
Enrollment
193 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
28
States / cities
Birmingham, Alabama • Los Angeles, California • Delray Beach, Florida + 20 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2012 · Synced Oct 4, 2026, 10:10 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Single Ascending Dose Safety and Tolerability of NTS-104 Healthy Adults

NCT05547438
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
NTS-104 TRIS, Placebo
Drug
Lead sponsor
NeuroTrauma Sciences, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 4, 2026, 10:10 AM EDT
Recruiting Phase 2 Interventional

Intra-Arterial Tenecteplase to Improve the Microvascular Hemodynamics After Mechanical Thrombectomy

NCT06904911
View directory record Official record
Conditions
Acute Ischemic Stroke From Large Vessel Occlusion
Interventions
intra-arterial tenecteplase administration
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 4, 2026, 10:10 AM EDT
Terminated No phase listed Observational Results available

Validation of Velocity Curvature Index as a Diagnostic Biomarker Tool for Assessment of Large Vessel Stroke

NCT05547412
View directory record Official record
Conditions
Stroke, Acute Ischemic Stroke
Interventions
NovaGuide 2 Intelligent Ultrasound System
Device
Lead sponsor
NeuraSignal Inc dba NovaSignal
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 9, 2024 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Phase 2 Interventional

A Proof of Concept Study to Evaluate CN-105 in ICH Patients

NCT03168581
View directory record Official record
Conditions
Intracerebral Hemorrhage
Interventions
CN-105
Drug
Lead sponsor
AegisCN LLC
Industry
Eligibility
30 Years to 80 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
5
States / cities
Lexington, Kentucky • Durham, North Carolina • Winston-Salem, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2020 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Not applicable Interventional

The Application of a Mental Practice Protocol in the Acute Inpatient Rehabilitation Setting

NCT04927728
View directory record Official record
Conditions
Stroke, Upper Extremity Paresis
Interventions
Mental Practice, Repetitive-Task Practice, Traditional Therapy
Other
Lead sponsor
Adventist HealthCare
Other
Eligibility
18 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 16, 2021 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Not applicable Interventional Results available

A Randomized, Concurrent Controlled Trial to Assess the Safety and Effectiveness of the Separator 3D as a Component of the Penumbra System in the Revascularization of Large Vessel Occlusion in Acute Ischemic Stroke

NCT01584609
View directory record Official record
Conditions
Acute Ischemic Stroke From Large Vessel Occlusion
Interventions
Penumbra System with Separator 3D, Penumbra System alone
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
8
States / cities
Newport Beach, California • Denver, Colorado • Hartford, Connecticut + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 13, 2018 · Synced Oct 4, 2026, 10:10 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers

Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military

NCT04058132
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Sildenafil Citrate 50Mg Tab, functional Near-infrared Spectroscopy (fNIRS), Carbon Dioxide (CO2) 5%, Neuropsychological Assessments, Gadolinium contrast infusion, Blood sample collection for research purposes, Structural brain Magnetic Resonance Imaging (MRI
Drug · Device · Other + 1 more
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years to 55 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Oct 4, 2026, 10:10 AM EDT
Completed No phase listed Observational

The Effect of Implementing Hyper-acute Stroke Guidelines on Decision-Making for or Against Thrombolytic Therapy for Stroke in the Emergency Department

NCT01050049
View directory record Official record
Conditions
Stroke
Interventions
Not listed
Lead sponsor
Temple University
Other
Eligibility
19 Years and older
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 15, 2010 · Synced Oct 4, 2026, 10:10 AM EDT
Completed Not applicable Interventional Results available

Study of the Penumbra Coil 400 System to Treat Aneurysm

NCT01465841
View directory record Official record
Conditions
Intracranial Aneurysms, Peripheral Aneurysms
Interventions
PC 400 coils (Penumbra )
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
Not listed
Enrollment
517 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
6
States / cities
Newport Beach, California • Chicago, Illinois • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Oct 4, 2026, 10:10 AM EDT