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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Recruiting Phase 1 Interventional

Mechanisms of Diuretic Resistance in Heart Failure, Aim 2

NCT05753059
View directory record Official record
Conditions
Heart Failure
Interventions
Placebo, Amiloride, Bendroflumethiazide
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jun 10, 2026, 6:16 PM EDT
Completed Not applicable Interventional

Reverse HFpEF: Ketogenic Reversal of Heart Failure With Preserved Ejection Fraction Study

NCT04942548
View directory record Official record
Conditions
Heart Failure
Interventions
Ketogenic Diet
Other
Lead sponsor
National Jewish Health
Other
Eligibility
21 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Jun 10, 2026, 6:16 PM EDT
Completed Phase 2 Interventional

Use of Ixmyelocel-T (Formerly Cardiac Repair Cell [CRC] Treatment) in Patients With Heart Failure Due to Dilated Cardiomyopathy (IMPACT-DCM)

NCT00765518
View directory record Official record
Conditions
Dilated Cardiomyopathy
Interventions
Ixmyelocel-T, Standard of Care
Biological · Other
Lead sponsor
Vericel Corporation
Industry
Eligibility
18 Years to 86 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
5
States / cities
Atlanta, Georgia • Cleveland, Ohio • Dallas, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated May 26, 2021 · Synced Jun 10, 2026, 6:16 PM EDT
Not listed Early Phase 1 Interventional

Pumps for Kids, Infants, and Neonates

NCT02954497
View directory record Official record
Conditions
Pediatric Heart Failure
Interventions
Surgical placement of the Jarvik 2015 VAD, Surgical Placement of Jarvik 2015 VAD
Device · Procedure
Lead sponsor
Carelon Research
Other
Eligibility
Not listed
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
7
States / cities
Palo Alto, California • Atlanta, Georgia • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Jun 10, 2026, 6:16 PM EDT
Completed Not applicable Interventional

Better Effectiveness After Transition - Heart Failure

NCT01360203
View directory record Official record
Conditions
Heart Failure
Interventions
Structured Telephone / Remote Outpatient Monitoring
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years and older
Enrollment
1,437 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
6
States / cities
Davis, California • Irvine, California • Los Angeles, California + 2 more
Source: ClinicalTrials.gov public record
Updated May 10, 2016 · Synced Jun 10, 2026, 6:16 PM EDT
Completed No phase listed Observational

Extension Phase of the Chronicle® Offers Management to Patients With Advanced Signs & Symptoms of Heart Failure Study

NCT00991120
View directory record Official record
Conditions
Heart Failure
Interventions
Chronicle Implantable Hemodynamic Monitor (IHM) System, Chronicle Implantable Cardioverter Defibrillator (ICD)
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
19
States / cities
Birmingham, Alabama • Springfield, Illinois • Fort Wayne, Indiana + 16 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2017 · Synced Jun 10, 2026, 6:16 PM EDT
Withdrawn No phase listed Observational

Hispanics With Metabolic Syndrome and Non-ischemic Heart Failure

NCT00804882
View directory record Official record
Conditions
Metabolic Syndrome, Heart Failure
Interventions
Not listed
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years to 59 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Apr 12, 2015 · Synced Jun 10, 2026, 6:16 PM EDT
Completed Not applicable Interventional

Motivational Enhancement - Acute Decompensated Heart Failure and OSA

NCT04752462
View directory record Official record
Conditions
Acute Decompensated Heart Failure, Obstructive Sleep Apnea, Motivational Enhancement, PAP Adherence
Interventions
Telemedicine Intensive Motivational Enhancement
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 8, 2025 · Synced Jun 10, 2026, 6:16 PM EDT
Completed Phase 1 Interventional

Phase 1 Safety and Pharmacokinetic Study of AI-700 in Patients With Diminished DLCO and COPD and/or CHF

NCT00156780
View directory record Official record
Conditions
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Interventions
AI-700
Drug
Lead sponsor
Acusphere
Industry
Eligibility
Not listed
Timeline
2004 – 2005
U.S. locations
1
States / cities
Watertown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2006 · Synced Jun 10, 2026, 6:16 PM EDT
Completed Not applicable Interventional

Correlating QLV Interval to Left Ventricular (LV) Lead Position in Patients Receiving Cardiac Resynchronization Therapy.

NCT02166762
View directory record Official record
Conditions
Heart Failure, Cardiomyopathy, Cardiac Arrhythmia
Interventions
QLV interval measurement
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 6, 2019 · Synced Jun 10, 2026, 6:16 PM EDT
Recruiting Not applicable Interventional

Forge AHEAD: Feasibility of Yoga to Improve Cognitive Function

NCT07489105
View directory record Official record
Conditions
Heart Failure, Rural Health, Engagement, Patient
Interventions
Yoga group
Behavioral
Lead sponsor
Auburn University
Other
Eligibility
55 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jun 10, 2026, 6:16 PM EDT
Terminated Not applicable Interventional Results available

Spinal Stimulation During Exercise in Heart Failure

NCT02659202
View directory record Official record
Conditions
Heart Failure
Interventions
Precision Spinal Cord Stimulator System
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Jun 10, 2026, 6:16 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Phrenic Nerve Stimulation for Treatment of Central Sleep Apnea

NCT03238937
View directory record Official record
Conditions
Sleep Apnea, Central, Heart Failure
Interventions
Phrenic nerve stimulator
Device
Lead sponsor
Steward St. Elizabeth's Medical Center of Boston, Inc.
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Brighton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 26, 2020 · Synced Jun 10, 2026, 6:16 PM EDT
Completed Phase 2 Interventional Results available

The Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in Patients Undergoing LVAD Implantation

NCT01442129
View directory record Official record
Conditions
Heart Failure, Cardiomyopathy, Ventricular Dysfunction
Interventions
MPC Intramyocardial injection, Control Solution
Biological
Lead sponsor
Deborah Ascheim
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
11
States / cities
Gainsville, Florida • Baltimore, Maryland • Minneapolis, Minnesota + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 30, 2015 · Synced Jun 10, 2026, 6:16 PM EDT
Withdrawn No phase listed Observational

Prediction of Expected Length of Hospital Stay Using Machine Learning

NCT04784351
View directory record Official record
Conditions
Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma, Gout Flare, Chronic Kidney Diseases, Hypertensive Urgency, Atrial Fibrillation Rapid, Anticoagulants; Increased
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Jun 10, 2026, 6:16 PM EDT
Completed No phase listed Observational

Clinical Performance Evaluation of AQT90 FLEX BNP and NT-proBNP

NCT01808872
View directory record Official record
Conditions
Heart Failure
Interventions
Not listed
Lead sponsor
Radiometer Medical ApS
Industry
Eligibility
21 Years and older
Enrollment
569 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 4, 2014 · Synced Jun 10, 2026, 6:16 PM EDT
Completed Phase 3 Interventional Results available

This Study Tests Empagliflozin in Patients With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF). The Study Looks at How Far Patients Can Walk in 6 Minutes and at Their Heart Failure Symptoms

NCT03448419
View directory record Official record
Conditions
Heart Failure
Interventions
Empagliflozin, Placebo
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
41
States / cities
Mobile, Alabama • Saraland, Alabama • Huntington Beach, California + 37 more
Source: ClinicalTrials.gov public record
Updated Nov 26, 2020 · Synced Jun 10, 2026, 6:16 PM EDT
Completed Phase 4 Interventional

ERTU-SODIUM: Study on the Effects of Ertugliflozin on Sodium Storage, Interstitial Volume, and Plasma Volume in HFrEF

NCT05152940
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction, Congestion
Interventions
Ertugliflozin, Placebo
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jun 10, 2026, 6:16 PM EDT
Completed Not applicable Interventional

Multi-Center Project: Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure

NCT06457152
View directory record Official record
Conditions
Heart Failure
Interventions
EHR-Emedded Alert
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 90 Years
Enrollment
1,136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Boston, Massachusetts • New York, New York • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jun 10, 2026, 6:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Ventricular Assist Device (VAD) Infection Prevention Survey

NCT03843021
View directory record Official record
Conditions
Heart Failure, Healthcare Associated Infection, Ventricular Assist Device
Interventions
VAD Infection Prevention Survey
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
208 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 13, 2023 · Synced Jun 10, 2026, 6:16 PM EDT
Completed No phase listed Observational

Quality of Life in Patients With Chronic Ischemic Heart Disease

NCT00005671
View directory record Official record
Conditions
Ischemic Heart Disease, Myocardial Ischemia
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
Not listed
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 10, 2026, 6:16 PM EDT
Completed No phase listed Observational

DISCOVERY: A Study Examining the Prevalence of TTR Mutations in Subjects Suspected of Having Cardiac Amyloidosis

NCT02252653
View directory record Official record
Conditions
Familial Amyloidotic Cardiomyopathy (FAC)
Interventions
Not listed
Lead sponsor
Alnylam Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
1,010 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
43
States / cities
Little Rock, Arkansas • Bakersfield, California • La Mesa, California + 32 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2016 · Synced Jun 10, 2026, 6:16 PM EDT
Terminated Not applicable Interventional Results available

Assessment of Pulmonary Congestion During Cardiac Hemodynamic Stress Testing

NCT04019613
View directory record Official record
Conditions
Dyspnea, Heart Failure With Preserved Ejection Fraction
Interventions
Lung ultrasound
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Jun 10, 2026, 6:16 PM EDT
Completed Phase 2 Interventional

RESTOR-MV: Randomized Evaluation of a Surgical Treatment for Off-Pump Repair of the Mitral Valve

NCT00120276
View directory record Official record
Conditions
Mitral Valve Regurgitation, Left Ventricular Dysfunction, Heart Failure
Interventions
Less invasive mitral valve repair
Device
Lead sponsor
Myocor
Industry
Eligibility
18 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
10
States / cities
Atlanta, Georgia • Springfield, Illinois • Ann Arbor, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated May 6, 2009 · Synced Jun 10, 2026, 6:16 PM EDT