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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Co-morbidity Clear all
Recruiting No phase listed Observational Accepts healthy volunteers

The DC Cohort Longitudinal HIV Status Neutral Study

NCT01206920
View directory record Official record
Conditions
HIV, AIDS
Interventions
Not listed
Lead sponsor
George Washington University
Other
Eligibility
Not listed
Enrollment
19,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2041
U.S. locations
14
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Sep 22, 2026, 10:05 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Psychological Treatment of Overweight Binge Eaters

NCT01208272
View directory record Official record
Conditions
Binge Eating Disorder, Cognitive Therapy/Methods, Mental Disorders/Epidemiology, Obesity/Epidemiology, Obesity/Therapy
Interventions
Cognitive Behavioral Therapy (CBT), Interpersonal Therapy (IPT)
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1994 – 1999
U.S. locations
2
States / cities
New Haaven, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 22, 2010 · Synced Sep 22, 2026, 10:05 PM EDT
Completed Phase 2 Interventional Results available

Compassion Meditation vs. Health Education for Veterans

NCT04651296
View directory record Official record
Conditions
Chronic Pain, Stress Disorders, Posttraumatic, Depression
Interventions
compassion meditation, health education
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 22, 2026, 10:05 PM EDT
Terminated No phase listed Observational

Obesity and Memory, mRNA, Body Composition, Comorbidity Scale

NCT00531505
View directory record Official record
Conditions
Obesity, Memory Deficits
Interventions
Not listed
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 15, 2015 · Synced Sep 22, 2026, 10:05 PM EDT
Recruiting Not applicable Interventional

Lean Beef as Part of a Healthy Meal Plan in Adolescents With Polycystic Ovary Syndrome (PCOS)/Polyendocrine Metabolic Ovarian Syndrome (PMOS)

NCT07780188
View directory record Official record
Conditions
PCOS (Polycystic Ovary Syndrome), Obese Adolescents, Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities, Overweight Adolescents, Irregular Menstrual Cycle, Irregular Menstrual Cycles, Hirsutism, Hyperandrogenism
Interventions
Beef+
Other
Lead sponsor
Texas A&M University
Other
Eligibility
11 Years to 17 Years · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 22, 2026, 10:05 PM EDT
Completed Phase 1 Interventional

Ketamine for Depression and Alcohol Dependence

NCT01551329
View directory record Official record
Conditions
Depression, Alcohol Dependence
Interventions
Ketalar (ketamine)
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 8, 2020 · Synced Sep 22, 2026, 10:05 PM EDT
Completed Phase 3 Interventional Results available

A Randomized, Double-blind Controlled Study Comparing LCZ696 to Medical Therapy for Comorbidities in HFpEF Patients

NCT03066804
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction
Interventions
sacubitril/valsartan, Enalapril, Valsartan, Placebo to match sacubitril/valsartan, Placebo to match enalapril, Placebo to match valsartan
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
45 Years and older
Enrollment
2,572 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
32
States / cities
Andalusia, Alabama • Mobile, Alabama • Beverly Hills, California + 29 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2021 · Synced Sep 22, 2026, 10:05 PM EDT
Withdrawn Not applicable Interventional

The Impact of Mindfulness Meditation in Veterans With Epilepsy

NCT03589755
View directory record Official record
Conditions
Epilepsy
Interventions
Mindfulness meditation
Behavioral
Lead sponsor
Miami VA Healthcare System
Federal
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 2, 2020 · Synced Sep 22, 2026, 10:05 PM EDT
Completed Not applicable Interventional Results available

Vitamin D Supplements for HIV-positive Patients on cART

NCT01295034
View directory record Official record
Conditions
HIV-associated Co-morbidities
Interventions
conventional vitamin D treatment, tiered/titrated vitamin D dosing
Dietary Supplement · Drug
Lead sponsor
Andrea Branch
Other
Eligibility
18 Years to 70 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Sep 22, 2026, 10:05 PM EDT
Completed Not applicable Interventional Results available

Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders

NCT01947647
View directory record Official record
Conditions
Major Depressive Disorder, Persistent Depressive Disorder, Posttraumatic Stress Disorder, Panic Disorder, Social Phobia, Specific Phobia, Generalized Anxiety Disorder, Obsessive Compulsive Disorder
Interventions
Transdiagnostic Behavior Therapy, Behavioral Activation Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 22, 2026, 10:05 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

The Cancer Stage Shifting Initiative: Registry and Biorepository to Research and Address Health Disparities in Cancer Care

NCT07461493
View directory record Official record
Conditions
Cancer, Cancer Comorbidities
Interventions
Not listed
Lead sponsor
National Minority Quality Forum
Other
Eligibility
35 Years and older
Enrollment
100,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2039
U.S. locations
2
States / cities
Flint, Michigan • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 22, 2026, 10:05 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants

NCT04505722
View directory record Official record
Conditions
Participants With or Without Stable Co-morbidities Associated With Progression to Severe COVID-19 at Different Stages of the Protocol
Interventions
Ad26.COV2.S, Placebo
Biological · Other
Lead sponsor
Janssen Vaccines & Prevention B.V.
Industry
Eligibility
18 Years and older
Enrollment
44,325 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
117
States / cities
Birmingham, Alabama • Huntsville, Alabama • Glendale, Arizona + 77 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2025 · Synced Sep 22, 2026, 10:05 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-mediated COVID-19 in Adults

NCT04614948
View directory record Official record
Conditions
Participants With or Without Stable Co-morbidities Associated With Progression to Severe COVID-19
Interventions
Ad26.COV2.S, Placebo
Biological · Other
Lead sponsor
Janssen Vaccines & Prevention B.V.
Industry
Eligibility
18 Years and older
Enrollment
31,835 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
63
States / cities
Vestavia Hills, Alabama • Phoenix, Arizona • Tucson, Arizona + 53 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2025 · Synced Sep 22, 2026, 10:05 PM EDT
Completed Phase 4 Interventional Results available

Brain Aging and Treatment Response in Geriatric Depression

NCT01902004
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Depression
Interventions
Escitalopram, Memantine, Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
60 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 14, 2019 · Synced Sep 22, 2026, 10:05 PM EDT
Completed Not applicable Interventional

Improving Delivery of Mental Health Services for Patients With Drug Use and Other Behavioral and Emotional Problems

NCT00787735
View directory record Official record
Conditions
Study Focusing on Integrated Versus Non-integrated Psychiatric Care in, Opioid-dependent and Methadone Treated Patients With Other Psychiatric, Diagnoses
Interventions
Counseling compliance
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Enrollment
380 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 5, 2017 · Synced Sep 22, 2026, 10:05 PM EDT
Recruiting No phase listed Observational

Improving Patient-Centered Care for Underserved Older African American Patients With Cardiovascular Comorbidities

NCT07748858
View directory record Official record
Conditions
Cardiovascular, Comorbidity, Diabetes, Inflammatory Joint Diseases, Chronic Kidney Diease, Chronic Obstructive Pulmonary Disease (COPD), Cardiovascular Disease
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
50 Years to 99 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 22, 2026, 10:05 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The IMPROV Project: Improving Mental Health and Substance Use Treatment Provision (IMPROV) Among People Living With HIV (Human Immunodeficiency Virus) in Atlanta

NCT05415891
View directory record Official record
Conditions
Mental Health Disorder, Substance Use Disorder, Stigmatization, Implementation Science
Interventions
Modified Health Policy Project (HPP) HIV-Stigma and Discrimination Reduction Training Curriculum, You℞ Decision prescribing platform
Behavioral · Device
Lead sponsor
RTI International
Other
Eligibility
18 Years and older
Enrollment
333 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
2
States / cities
Decatur, Georgia • Duluth, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 12, 2022 · Synced Sep 22, 2026, 10:05 PM EDT
Completed Phase 2 Interventional

Inaxaplin in Participants With Proteinuric APOL1 Mediated Kidney Disease With or Without Comorbidities

NCT06794996
View directory record Official record
Conditions
Proteinuric Kidney Disease
Interventions
Inaxaplin
Drug
Lead sponsor
Vertex Pharmaceuticals Incorporated
Industry
Eligibility
18 Years to 67 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
35
States / cities
Huntsville, Alabama • Hollywood, Florida • Lauderdale Lakes, Florida + 28 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 22, 2026, 10:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Acceptance and Commitment Therapy for Aging People Living With HIV in Chronic Pain

NCT03699020
View directory record Official record
Conditions
HIV/AIDS, Chronic Pain
Interventions
Acceptance and Commitment Therapy (ACT), Chronic Pain Education
Behavioral · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
50 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 22, 2026, 10:05 PM EDT
Enrolling by invitation Not applicable Interventional

Personalizing Treatment Delivery

NCT05821634
View directory record Official record
Conditions
Anxiety Disorders and Symptoms, PTSD and Trauma-related Symptoms, Alcohol; Use, Problem; Alcohol Use Disorder
Interventions
Personalized intervention condition: Cognitive behavioral therapy skills, Therapeutic control condition: Cognitive behavioral therapy skills, Tracking control condition: Supportive counseling
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 65 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 22, 2026, 10:05 PM EDT
Not yet recruiting Not applicable Interventional

ENLIGHT Trial: ESG With Fundal Mucosal Ablation

NCT07792226
View directory record Official record
Conditions
Obesity, Obesity (Body Mass Index >30 kg/m2)
Interventions
Endoscopic Sleeve Gastroplasty (ESG), Fundal Mucosal Ablation
Procedure
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 22, 2026, 10:05 PM EDT
Active, not recruiting No phase listed Observational

Pragmatic Assessment of the NuvoAir Clinical Service in the Management of Patients With Chronic Obstructive Pulmonary Disease

NCT05955482
View directory record Official record
Conditions
COPD, Comorbidities and Coexisting Conditions
Interventions
NuvoAir Clinical Service
Other
Lead sponsor
NuvoAir Medical PC
Industry
Eligibility
30 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Marshfield, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 27, 2025 · Synced Sep 22, 2026, 10:05 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Preventing Tipping Points in High Comorbidity Patients: A Lifeline From Health Coaches

NCT04176510
View directory record Official record
Conditions
Comorbidity, Self-Management
Interventions
Health Coach Intervention
Behavioral
Lead sponsor
Clinical Directors Network
Network
Eligibility
18 Years and older
Enrollment
1,920 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
4
States / cities
Chicago, Illinois • Brooklyn, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 22, 2026, 10:05 PM EDT
Active, not recruiting Phase 3 Interventional

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity

NCT06972459
View directory record Official record
Conditions
Obesity, Overweight
Interventions
Orforglipron, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
35
States / cities
Sun City West, Arizona • Tucson, Arizona • San Ramon, California + 31 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 22, 2026, 10:05 PM EDT