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ClinicalTrials.gov public records Last synced Oct 29, 2026, 3:51 AM EDT

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Showing 1513–1536 of 5,333 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depression Clear all
Completed Not applicable Interventional

Making Decisions About Depression Medications

NCT01502891
View directory record Official record
Conditions
Depression
Interventions
Decision Aid
Other
Lead sponsor
Victor Montori
Other
Eligibility
18 Years and older
Enrollment
301 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
4
States / cities
Minneapolis, Minnesota • Rochester, Minnesota • Saint Paul, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 31, 2015 · Synced Oct 29, 2026, 3:51 AM EDT
Active, not recruiting Phase 1 Interventional

Depression Treatment and Screening in Ovarian Cancer Patients

NCT00515372
View directory record Official record
Conditions
Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
Interventions
Telephone Counseling, Usual Care
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
409 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 29, 2026, 3:51 AM EDT
Terminated Phase 3 Interventional

Study to Assess the Safety and Effectiveness of NMRA-335140-501

NCT06029439
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
NMRA-335140
Drug
Lead sponsor
Neumora Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
904 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
126
States / cities
Huntsville, Alabama • Phoenix, Arizona • Bentonville, Arkansas + 94 more
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Phase 2 Interventional Results available

Poststroke Depression in Hemorrhagic Stroke

NCT03826875
View directory record Official record
Conditions
Stroke Hemorrhagic, Depression
Interventions
Fluoxetine, Placebo
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 85 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Using the LENA System in Early Intervention - b

NCT03480841
View directory record Official record
Conditions
Depression
Interventions
Language ENhancement Assessment/intervention system
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 19, 2019 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Not applicable Interventional

Randomized, School-based Effectiveness Trial of the Adolescent Depression Awareness Program

NCT02099305
View directory record Official record
Conditions
Adolescent - Emotional Problem, Depression, Prevention Harmful Effects
Interventions
Adolescent Depression Awareness Program (ADAP)
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
12 Years to 18 Years
Enrollment
17,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 12, 2017 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Psychotherapy on Stress Biochemistry: An RCT of Psychotherapy and Emotional Freedom Techniques (EFT)

NCT00641394
View directory record Official record
Conditions
Stress, Depression, Anxiety
Interventions
Psychotherapy: Emotional Freedom Techniques (EFT), Cognitive Behavioral Therapy (CBT)
Behavioral
Lead sponsor
Soul Medicine Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Santa Rosa, California
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Phase 3 Interventional

Efficacy and Safety of SR58611A in Patients With Major Depressive Disorder

NCT00252356
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
SR58611A
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
468 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 12, 2009 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Not applicable Interventional Results available

Study of Mood Effects of Varenicline (Chantix) in Depressed Outpatient Smokers

NCT00525837
View directory record Official record
Conditions
Depressive Disorder, Smoking
Interventions
fixed dose varenicline, varenicline
Drug
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 28, 2018 · Synced Oct 29, 2026, 3:51 AM EDT
Not yet recruiting Not applicable Interventional

Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation

NCT07842601
View directory record Official record
Conditions
Opioid Use Disorder, Major Depressive Disorder (MDD)
Interventions
Transcranial Magnetic Stimulation (TMS), Sham Transcranial Magnetic Stimulation (TMS)
Device
Lead sponsor
University of Kentucky
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 29, 2026, 3:51 AM EDT
Recruiting Not applicable Interventional

Project neuroARTEMIS

NCT06814275
View directory record Official record
Conditions
Stimulant Use, Human Immunodeficiency Virus (HIV), Depression
Interventions
ARTEMIS, Contingency management for Antiretroviral (ARV) adherence
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 59 Years
Enrollment
189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Phase 1 Interventional

Treatment of Depressed Women Who Have Been Sexually Abused

NCT00042237
View directory record Official record
Conditions
Depression
Interventions
Schema Therapy
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2001
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 22, 2013 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Phase 2 Interventional Results available

Study to Treat Major Depressive Disorder With a New Medication

NCT03043560
View directory record Official record
Conditions
Depressive Disorder, Anhedonia
Interventions
Ezogabine, Placebos
Drug
Lead sponsor
James Murrough
Other
Eligibility
18 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
New York, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 23, 2020 · Synced Oct 29, 2026, 3:51 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Reducing Daily Stress Among Sexual and Gender Minorities

NCT05131360
View directory record Official record
Conditions
Social Discrimination, Sexual and Gender Minorities, Mindfulness
Interventions
Introduction Only, Purpose Only, Connection Only, Connection and Purpose, Awareness Only, Awareness and Purpose, Awareness, Purpose, and Connection, Awareness and Connection
Behavioral
Lead sponsor
New York University
Other
Eligibility
18 Years to 29 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 23, 2021 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Not applicable Interventional

Effectiveness of Nurse-delivered Care for Adherence/Mood in HIV in South Africa

NCT02696824
View directory record Official record
Conditions
Immunodeficiency Virus, Human, Depressive Symptoms
Interventions
Cognitive Behavioral Therapy for Adherence and Depression
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
Miami, Florida • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 19, 2021 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Dopaminergic Dysfunction in Late-Life Depression

NCT04469959
View directory record Official record
Conditions
Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa, Gait Impairment
Interventions
L-Dopa, Placebo
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 29, 2026, 3:51 AM EDT
Not listed No phase listed Observational

A Music-Based Mobile App for People Living With Alzheimer's Disease and Related Dementias (ADRD)

NCT06140342
View directory record Official record
Conditions
Dementia, Agitation, Depressive Symptoms
Interventions
Feasibility study of music-based mobile app
Behavioral
Lead sponsor
Autotune Me LLC
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Nov 24, 2023 · Synced Oct 29, 2026, 3:51 AM EDT
Recruiting Phase 4 Interventional

Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression

NCT06610305
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Transdermal estradiol, Progesterone, Transdermal placebo patch, placebo capsule
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hippocampal Plasticity of Young Adults With Childhood Adversity

NCT02816502
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Stress Management Skill Building Program A, Stress Management Skill Building Program B
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 35 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Oct 29, 2026, 3:51 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Spirulina Supplementation on Mental Health in Healthy Adults

NCT06936202
View directory record Official record
Conditions
Depression, Mental Acuity
Interventions
Spirulina capsules, Placebo
Other
Lead sponsor
Arizona State University
Other
Eligibility
16 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 19, 2025 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Not applicable Interventional Results available

Look AHEAD: Action for Health in Diabetes

NCT00017953
View directory record Official record
Conditions
Diabetes, Myocardial Infarction, Stroke, Kidney Diseases, Bone Diseases, Dyslipidemia
Interventions
Lifestyle Intervention, Diabetes Support and Education
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
55 Years to 76 Years
Enrollment
5,145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2020
U.S. locations
18
States / cities
Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 14 more
Source: ClinicalTrials.gov public record
Updated Aug 2, 2023 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Not applicable Interventional Results available

Integrative Medicine Group Visits: A Patient-Centered Approach to Reducing Chronic Pain and Depression

NCT02262377
View directory record Official record
Conditions
Chronic Pain, Depression
Interventions
Integrative Medicine Group Visits
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 29, 2026, 3:51 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Buprenorphine Used With Treatment Resistant Depression in Older Adults

NCT02181231
View directory record Official record
Conditions
Major Depressive Disorder, Depression
Interventions
venlafaxine XR, buprenorphine, Placebo
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
50 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 4, 2019 · Synced Oct 29, 2026, 3:51 AM EDT
Completed No phase listed Observational Results available

Treatment-Resistant Depression Registry

NCT00320372
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Not listed
Lead sponsor
Cyberonics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
795 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
55
States / cities
Tucson, Arizona • Beverly Hills, California • Garden Grove, California + 46 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2015 · Synced Oct 29, 2026, 3:51 AM EDT