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ClinicalTrials.gov public records Last synced Sep 30, 2026, 6:27 PM EDT

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Showing 25–48 of 2,429 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depression Disorders and Symptoms Clear all
Completed Phase 1 Interventional

A Clinic-based Prevention Program for Families of Depressed Mothers

NCT00149812
View directory record Official record
Conditions
Depression, Attention Deficit Disorder With Hyperactivity, Conduct Disorder
Interventions
Family Functioning Intervention
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
8 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 5, 2016 · Synced Sep 30, 2026, 6:27 PM EDT
Active, not recruiting No phase listed Observational

Depression and Adherence in Head and Neck Cancer

NCT00498875
View directory record Official record
Conditions
Oropharyngeal Cancer, Head and Neck Cancer
Interventions
Questionnaire, Depression Intervention
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Phase 3 Interventional Results available

A Study Of DVS SR In Treatment Of Children And Adolescent Outpatients With MDD

NCT01372150
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
desvenlafaxine succinate sustained release, fluoxetine, placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
7 Years to 17 Years
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
41
States / cities
Dothan, Alabama • Goodyear, Arizona • Tucson, Arizona + 31 more
Source: ClinicalTrials.gov public record
Updated Jan 15, 2019 · Synced Sep 30, 2026, 6:27 PM EDT
Recruiting Not applicable Interventional

Family Spirit Strengths

NCT05836090
View directory record Official record
Conditions
Depressive Symptoms, Anxiety Disorders and Symptoms, Substance Use, Mental Health Issue
Interventions
Family Spirit Strengths (FSS), Family Spirit Nurture
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
14 Years and older · Female only
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
3
States / cities
Chinle, Arizona • Pokagon, Michigan • Shiprock, New Mexico
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 30, 2026, 6:27 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Occupational Therapy for Mental Health and Engagement in Neurorehabilitation

NCT07375485
View directory record Official record
Conditions
Acquired Brain Injury, Mental Health, Depressive Symptoms, Anxiety Symptoms, Loneliness
Interventions
Multifaceted implementation program
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
2
States / cities
Denver, Colorado • Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Phase 2 Interventional

Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disorder

NCT05536414
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Centanafadine, Escitalopram, Placebo
Drug
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
337 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
62
States / cities
Yuma, Arizona • Bryant, Arkansas • Glendale, California + 53 more
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Not applicable Interventional

One-Day Intervention for Depression and Impairment in Migraine Patients

NCT02108678
View directory record Official record
Conditions
Migraine, Depression
Interventions
ACT-ME, Migraine Education Only
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 22, 2017 · Synced Sep 30, 2026, 6:27 PM EDT
Completed No phase listed Observational

Psychosocial Correlates and Coping Strategies Associated With Long-Term Survival of HIV-Infected Children

NCT00001435
View directory record Official record
Conditions
Acquired Immunodeficiency Syndrome, Depressive Disorder, HIV Infections
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
Not listed
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Not applicable Interventional

Mental Health First Aid for College Students

NCT02021344
View directory record Official record
Conditions
Depression, Anxiety, Suicidal Ideation, Eating Disorders
Interventions
Mental Health First Aid
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
2,543 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 27, 2013 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Phase 1 Interventional

Phase I: At-Home Support for Rural Women Using Group Video Calling

NCT01672684
View directory record Official record
Conditions
Depression, Post-traumatic Stress Disorder, Recurrent Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer
Interventions
support group therapy, educational intervention
Procedure · Other
Lead sponsor
Stanford University
Other
Eligibility
21 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Nevada City, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 17, 2014 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Not applicable Interventional Results available

Groups for Regaining Our Wellbeing

NCT03058952
View directory record Official record
Conditions
Gulf War, Fatigue, Pain, Depression
Interventions
Mindfulness-Based Stress Reduction, Chronic Disease Self-Management Program
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 21, 2024 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Not applicable Interventional

Using an Online Patient Monitoring System to Improve Care for Children With Chronic Conditions

NCT02097355
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder, Asthma, Autism Spectrum Disorder, Depression, Epilepsy
Interventions
TriVox for clinical care
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Not listed
Enrollment
946 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Sep 30, 2026, 6:27 PM EDT
Terminated Phase 3 Interventional Results available

Escitalopram in Treating Depression in Patients With Advanced Lung or Gastrointestinal Cancer

NCT00387348
View directory record Official record
Conditions
Colorectal Cancer, Depression, Esophageal Cancer, Extrahepatic Bile Duct Cancer, Fatigue, Gallbladder Cancer, Gastric Cancer, Liver Cancer, Lung Cancer, Pancreatic Cancer
Interventions
escitalopram oxalate, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
35 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 3, 2012 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Not applicable Interventional

Depression In Juvenile Diabetics

NCT00005116
View directory record Official record
Conditions
Depression, Diabetes Mellitus, Insulin-Dependent
Interventions
psychotherapy
Behavioral
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
8 Years to 16 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 2, 2010 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Phase 2 Interventional

A Study of Naltrexone SR/ Bupropion SR in Overweight or Obese Subjects With Major Depression

NCT00624858
View directory record Official record
Conditions
Depression
Interventions
naltrexone SR 32 mg/ bupropion SR 360 mg daily
Drug
Lead sponsor
Orexigen Therapeutics, Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Mason, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 30, 2012 · Synced Sep 30, 2026, 6:27 PM EDT
Recruiting Phase 3 Interventional

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

NCT06911112
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
NBI-1065845, Placebo
Drug
Lead sponsor
Neurocrine Biosciences
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
17
States / cities
Huntsville, Alabama • Bryant, Arkansas • Glendale, California + 14 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 30, 2026, 6:27 PM EDT
Enrolling by invitation Not applicable Interventional

Financial Incentives for Veteran Therapy Completion

NCT06234371
View directory record Official record
Conditions
Motivation, Stress Disorder, Post Traumatic Stress Disorder, Depression, Depressive Disorder
Interventions
Financial Incentive
Behavioral
Lead sponsor
Christopher Cronin
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
3
States / cities
Dallas, Texas • Denton, Texas • Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2025 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Desipramine for Improving Cellular Signaling and Decreasing Symptoms of Major Depression

NCT00320632
View directory record Official record
Conditions
Depression
Interventions
Desipramine
Drug
Lead sponsor
Harvard Medical School (HMS and HSDM)
Other
Eligibility
19 Years to 64 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1990 – 1993
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 19, 2015 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Social Work Intervention Focused on Transitions

NCT02232126
View directory record Official record
Conditions
Study Focus: 30-day Rehospitalizations Among At-risk Older Adults Randomized to a Social Work-driven Care Transitions Intervention, Heart Disease, Diabetes, Hypertension, Cancer, Depression, Asthma, Chronic Heart Failure, Chronic Obstructive Pulmonary Disease, Stroke
Interventions
SWIFT home intervention
Other
Lead sponsor
University of Southern California
Other
Eligibility
65 Years to 110 Years
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
2
States / cities
Los Angeles, California • Pasadena, California
Source: ClinicalTrials.gov public record
Updated Nov 9, 2023 · Synced Sep 30, 2026, 6:27 PM EDT
Active, not recruiting Phase 3 Interventional

"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

NCT06564818
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
CYB003, Psychological Support, Placebo
Drug · Behavioral
Lead sponsor
Cybin IRL Limited
Industry
Eligibility
18 Years to 85 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
45
States / cities
Phoenix, Arizona • Tucson, Arizona • Bellflower, California + 35 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Sep 30, 2026, 6:27 PM EDT
Not listed No phase listed Observational

Multimodal Perioperative Pain Management: ComfortSafe Program

NCT04046068
View directory record Official record
Conditions
Post-operative Pain, Post-operative Nausea and Vomiting, Respiratory Depression, Confusion Postoperative
Interventions
ComfortSafe Care
Procedure
Lead sponsor
Georgetown University
Other
Eligibility
21 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Not applicable Interventional

Life Improvement Following Traumatic Brain Injury

NCT00878150
View directory record Official record
Conditions
Traumatic Brain Injury, Depression
Interventions
In-person Cognitive Behavioral Therapy, Telephone Cognitive Behavioral Therapy
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 18, 2013 · Synced Sep 30, 2026, 6:27 PM EDT
Completed Phase 2 Interventional

New Drugs in the Treatment of Mood Disorders

NCT00001482
View directory record Official record
Conditions
Anxiety Disorder, Mood Disorder, Psychotic Disorder
Interventions
Lamotrigine (Lamictal® (Registered Trademark), Gabapentin (Neurontin® (Registered Trademark))
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2001
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Sep 30, 2026, 6:27 PM EDT
Not listed Not applicable Interventional

Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults

NCT05976659
View directory record Official record
Conditions
Major Depressive Disorder, Alzheimer Disease, Dementia, Nervous System Diseases, Memory Disorders, Depressive Disorder
Interventions
Transcranial direct current stimulation (tDCS); Transcranial alternating current stimulation (tACS)
Device
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
55 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 4, 2023 · Synced Sep 30, 2026, 6:27 PM EDT