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ClinicalTrials.gov public records Last synced Oct 28, 2026, 1:38 PM EDT

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Showing 1–24 of 55 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Infrequent Bowel Movements Clear all
Completed Phase 4 Interventional Results available

Study to Gather Information on the Acceptability of a New Flavor System With Increasing Levels of 2, 4, 6 g or Higher of Mannitol for PEG 3350 in Subjects Having Infrequent Bowel Movements.

NCT04534465
View directory record Official record
Conditions
Constipation
Interventions
Polyethylene glycol (MiraLAX, BAY81-8430), Mannitol
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 12, 2020 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Phase 1 Interventional

Study to Evaluate the Effects of RM-131 in Patients With Chronic Constipation

NCT02137642
View directory record Official record
Conditions
Chronic Constipation
Interventions
RM-131, Placebo
Drug
Lead sponsor
Motus Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 22, 2016 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Bacillus Subtilis DE111® on Daily Bowel Movements

NCT04083521
View directory record Official record
Conditions
Bowel Movement Regulation, Occasional Constipation, Occasional Diarrhea
Interventions
Bacillus subtilis DE111®
Dietary Supplement
Lead sponsor
Deerland Enzymes
Industry
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Kennesaw, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 10, 2019 · Synced Oct 28, 2026, 1:38 PM EDT
Completed No phase listed Observational

Effect of Propofol on Internal Anal Sphincter Pressure During ARM

NCT01793753
View directory record Official record
Conditions
Chronic Constipation
Interventions
Propofol
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
2 Years to 6 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 14, 2016 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Phase 2 Interventional

Phase 2 Study of MD-1100 Acetate Administered for 14 Days to Patients Meeting Criteria for Chronic Constipation

NCT00306748
View directory record Official record
Conditions
Constipation
Interventions
MD-1100 Acetate
Drug
Lead sponsor
Ironwood Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
14
States / cities
Huntsville, Alabama • North Little Rock, Arkansas • Boynton Beach, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2009 · Synced Oct 28, 2026, 1:38 PM EDT
Not listed Not applicable Interventional

Trancutaneous Abdominal Stimulation on Bowel Function.

NCT04627168
View directory record Official record
Conditions
Spinal Cord Injuries, Constipation
Interventions
Non-invasive, surface electrical stimulation device, DS5 Digitimer
Device
Lead sponsor
Amol Soin, M.D., MBA
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 13, 2022 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Phase 3 Interventional Results available

Phase III, Randomized, Double-Blind, Placebo-Controlled, Trial of Linaclotide Administered to Patients With Chronic Constipation

NCT00765882
View directory record Official record
Conditions
Chronic Constipation
Interventions
Linaclotide 290 micrograms, Linaclotide 145 micrograms, Placebo
Drug
Lead sponsor
Forest Laboratories
Industry
Eligibility
18 Years and older
Enrollment
633 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
100
States / cities
Birmingham, Alabama • Huntsville, Alabama • Chandler, Arizona + 89 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2013 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Lubiprostone and Mucus Secretion in Patients With Chronic Constipation

NCT01447849
View directory record Official record
Conditions
Constipation
Interventions
lubiprostone, placebo
Drug
Lead sponsor
Texas Tech University Health Sciences Center, El Paso
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2017 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of Respiratory Muscle Training and Patient Education on Chronic Constipation Outcomes

NCT05823259
View directory record Official record
Conditions
Constipation, Constipation - Functional, Dyssynergia
Interventions
Hybrid Telehealth Program: Respiratory Muscle Training and Patient Education, Standard Physical Therapy Care
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Dec 13, 2024 · Synced Oct 28, 2026, 1:38 PM EDT
Active, not recruiting Phase 4 Interventional

Efficacy of Linaclotide in Type II Diabetics With Chronic Constipation

NCT03119584
View directory record Official record
Conditions
Chronic Constipation, Diabete Mellitus
Interventions
linaclotide or placebo
Drug
Lead sponsor
Texas Tech University Health Sciences Center, El Paso
Other
Eligibility
18 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2027
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Apr 3, 2026 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Phase 3 Interventional

Study to Evaluate Long-Term Safety, Tolerability, and Satisfaction With Prucalopride in Chronic Constipation

NCT00987844
View directory record Official record
Conditions
Chronic Constipation
Interventions
Prucalopride
Drug
Lead sponsor
Movetis
Industry
Eligibility
18 Years and older
Enrollment
1,775 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1998
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 1, 2009 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Phase 2 Interventional

Phase 2 Study to Evaluate Safety and Efficacy of RM-131 Administered to Patients With Chronic Constipation

NCT01781104
View directory record Official record
Conditions
Constipation
Interventions
RM-131, Placebo
Drug
Lead sponsor
Motus Therapeutics, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
3
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 23, 2016 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Phase 4 Interventional

Polyethyleneglycol3350 vs Tegaserod in Treatment of Patients With Chronic Constipation

NCT00153140
View directory record Official record
Conditions
Constipation
Interventions
polyethyleneglycol3350
Drug
Lead sponsor
Braintree Laboratories
Industry
Eligibility
18 Years to 64 Years
Enrollment
239 participants
Timeline
Started 2004
U.S. locations
25
States / cities
Mobile, Alabama • Glendale, Arizona • Anaheim, California + 21 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2013 · Synced Oct 28, 2026, 1:38 PM EDT
Completed No phase listed Observational

Development of an Instrument to Measure Quality of Life in Children With Chronic Constipation and Soiling

NCT00677508
View directory record Official record
Conditions
Constipation, Fecal Incontinence
Interventions
Not listed
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
2 Years to 18 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 30, 2020 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Not applicable Interventional

Perineal Self-Acupressure

NCT01867944
View directory record Official record
Conditions
Chronic Constipation, Constipation, Hemorrhoids
Interventions
Perineal Self-Acupressure, Educational Control
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2016 · Synced Oct 28, 2026, 1:38 PM EDT
Terminated Phase 2 Interventional

Phase II, Randomized, Placebo-Controlled Study of ATI-7505 in Patients With Chronic Idiopathic Constipation

NCT00501241
View directory record Official record
Conditions
Chronic Constipation
Interventions
ATI-7505
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years to 75 Years
Enrollment
214 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
20
States / cities
Anaheim, California • San Carlos, California • San Diego, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2009 · Synced Oct 28, 2026, 1:38 PM EDT
Withdrawn No phase listed Observational

A Pilot Study to Explore the Role of Gut Flora in Chronic Constipation

NCT04148248
View directory record Official record
Conditions
Constipation, Constipation Chronic Idiopathic, Constipation - Functional, Constipation (Excl Faecal Impaction)
Interventions
No intervention
Other
Lead sponsor
ProgenaBiome
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
1
States / cities
Ventura, California
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal Bloating

NCT01642914
View directory record Official record
Conditions
Chronic Constipation, Constipation
Interventions
Linaclotide 290 micrograms, Linaclotide 145 micrograms, Matching placebo
Drug
Lead sponsor
Forest Laboratories
Industry
Eligibility
18 Years and older
Enrollment
487 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
146
States / cities
Chandler, Arizona • Glendale, Arizona • Goodyear, Arizona + 125 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2016 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Phase 4 Interventional Results available

Study to Investigate Prucalopride vs. Polyethylene Glycol 3350 on Colon Activity

NCT01707667
View directory record Official record
Conditions
Chronic Constipation
Interventions
prucalopride, PEG 3350
Drug
Lead sponsor
Shire
Industry
Eligibility
18 Years to 75 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 2, 2021 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Not applicable Interventional

Kiwifruit, Prunes, & Fiber for Abdominal and Bowel Symptoms in US Patients With Chronic Constipation

NCT03569527
View directory record Official record
Conditions
Chronic Constipation
Interventions
Kiwifruit, Fiber, Prunes
Dietary Supplement
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 17, 2019 · Synced Oct 28, 2026, 1:38 PM EDT
Not listed No phase listed Observational

Colonic Transit Time Validation Study

NCT00857363
View directory record Official record
Conditions
Constipation
Interventions
Not listed
Lead sponsor
The SmartPill Corporation
Industry
Eligibility
18 Years to 80 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
12
States / cities
Tucson, Arizona • Los Angeles, California • Iowa City, Iowa + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 15, 2010 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Phase 3 Interventional Results available

Trial of Linaclotide in Patients With Chronic Constipation

NCT00730015
View directory record Official record
Conditions
Chronic Constipation
Interventions
Matching Placebo, Linaclotide
Drug
Lead sponsor
Ironwood Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
643 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
105
States / cities
Birmingham, Alabama • Huntsville, Alabama • Chandler, Arizona + 98 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2013 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Phase 3 Interventional Results available

12-Week Study of Plecanatide for CIC (The CIC3 Study)

NCT01982240
View directory record Official record
Conditions
Chronic Idiopathic Constipation
Interventions
Plecanatide, Placebo, Bisacodyl
Drug
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
1,394 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
177
States / cities
Birmingham, Alabama • Dothan, Alabama • Gulf Shores, Alabama + 143 more
Source: ClinicalTrials.gov public record
Updated Dec 26, 2019 · Synced Oct 28, 2026, 1:38 PM EDT
Completed Not applicable Interventional

A Rapid Clinical Care Pathway to Care for Patients Affected by Chronic Constipation

NCT07032376
View directory record Official record
Conditions
Constipation
Interventions
Survey, Rectal Expulsion Device use
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 28, 2026, 1:38 PM EDT