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Showing 1–24 of 1,212 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Knee Arthritis Clear all
Terminated No phase listed Observational

Journey II BCS CMS Total Knee System Compared to Other PS Total Knee Systems in PT Setting

NCT02820766
View directory record Official record
Conditions
Osteoarthritis, Degenerative Arthritis, Traumatic Arthritis
Interventions
Not listed
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
3
States / cities
Annapolis, Maryland • Eugene, Oregon • State College, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 9, 2017 · Synced Jul 22, 2026, 5:26 PM EDT
Completed Phase 1 Interventional

Effects of Synvisc on Cartilage in Knee Osteoarthritis (OA)

NCT00949494
View directory record Official record
Conditions
Osteoarthritis
Interventions
Synvisc
Device
Lead sponsor
Endeavor Health
Other
Eligibility
40 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Chicago, Illinois • Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 9, 2019 · Synced Jul 22, 2026, 5:26 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis

NCT06257537
View directory record Official record
Conditions
Osteo Arthritis Knee, Arthritis
Interventions
Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, 2.5% Diclofenac Patches, SAM Patch
Device · Drug · Other
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
50 Years to 85 Years
Enrollment
307 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
3
States / cities
Stamford, Connecticut • Trumbull, Connecticut • Dryden, New York
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 22, 2026, 5:26 PM EDT
Completed Phase 2 Interventional

Celution Prepared Adipose Derived Regenerative Cells in the Treatment of Osteoarthritis of the Knee

NCT02326961
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Celution Device, Placebo
Device · Other
Lead sponsor
Cytori Therapeutics
Industry
Eligibility
40 Years to 69 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
11
States / cities
Mesa, Arizona • Little Rock, Arkansas • La Mesa, California + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2016 · Synced Jul 22, 2026, 5:26 PM EDT
Not listed Not applicable Interventional

Live and Interactive Fitness Training Program (Vivo Knee OA)

NCT06462560
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Vivo Online Exercise Program, Medbridge Home program
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
55 Years to 85 Years
Enrollment
334 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Jun 16, 2024 · Synced Jul 22, 2026, 5:26 PM EDT
Not listed Phase 1 Interventional

Electrical Stimulation After Total Knee Arthroplasty

NCT00224913
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
Neuromuscular electrical stimulation, Voluntary exercise
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
45 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2002
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Oct 11, 2005 · Synced Jul 22, 2026, 5:26 PM EDT
Recruiting Not applicable Interventional

Move and Snooze: Adding Insomnia Treatment to an Exercise Program to Improve Pain Outcomes in Older Adults With Knee Osteoarthritis

NCT06580561
View directory record Official record
Conditions
Knee Osteoarthritis, Insomnia
Interventions
Personalized exercise coaching, Cognitive behavioral therapy for Insomnia
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 22, 2026, 5:26 PM EDT
Active, not recruiting Not applicable Interventional

Geniculate Artery Embolization for Osteoarthritis

NCT04456569
View directory record Official record
Conditions
Osteo Arthritis Knee, Arthritis, Osteoarthritis, Osteoarthritis, Knee
Interventions
Geniculate Artery Embolization
Device
Lead sponsor
University of Minnesota
Other
Eligibility
40 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jul 22, 2026, 5:26 PM EDT
Terminated Not applicable Interventional

Shared Decision Making and How It Impacts the Patient Understanding

NCT04011488
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Shared Decision Making Tool
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
45 Years to 64 Years · Female only
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 7, 2019 · Synced Jul 22, 2026, 5:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Corticospinal Excitability and Rehab in Knee Osteoarthritis

NCT02036866
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Transcutaneous Electrical Nerve Stimulation, Physical Therapy Exercises, No Intervention
Other
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Dec 13, 2015 · Synced Jul 22, 2026, 5:26 PM EDT
Not listed No phase listed Observational

A Prospective Radiostereometric Analysis (RSA) and Clinical Evaluation of the Triathlon Tritanium Total Knee Replacement

NCT02373761
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Stryker Triathlon Tritanium primary knee
Device
Lead sponsor
Scott Sporer
Other
Eligibility
18 Years to 80 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2015
U.S. locations
1
States / cities
Winfield, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 26, 2015 · Synced Jul 22, 2026, 5:26 PM EDT
Completed Phase 4 Interventional Results available

Knee Arthroplasty Performed With Conventional and Customized Instrumentation

NCT01124305
View directory record Official record
Conditions
Knee Arthritis
Interventions
Customized Patient Instrumentation, Traditional Instrumentation
Device
Lead sponsor
Anderson Orthopaedic Research Institute
Other
Eligibility
Not listed
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Alexandria, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 17, 2013 · Synced Jul 22, 2026, 5:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Incorporating Patient-Reported Outcomes Into Shared Decision Making With Patients With Osteoarthritis of the Hip or Knee

NCT04805554
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Joint Insights decision aid
Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
45 Years to 89 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 4, 2024 · Synced Jul 22, 2026, 5:26 PM EDT
Withdrawn Phase 4 Interventional

Exparel vs Exparel Plus ACB in TKAs

NCT02365727
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Liposomal bupivacaine, Ropivacaine, Epinephrine, Clonidine, Saline
Drug
Lead sponsor
The Hawkins Foundation
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 13, 2016 · Synced Jul 22, 2026, 5:26 PM EDT
Withdrawn Not applicable Interventional

TKR With and Without the Use of Intra-operative Sensing

NCT04251442
View directory record Official record
Conditions
Osteoarthritis
Interventions
OrthoSensor Verasense Technology
Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
40 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 25, 2022 · Synced Jul 22, 2026, 5:26 PM EDT
Active, not recruiting Not applicable Interventional

Pain & Aging: Combined Interventions for Fitness in the Community Study

NCT04099394
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Behavioral Health, Health Education
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
65 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Jul 22, 2026, 5:26 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty

NCT02570503
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Ropivacaine, Ketorolac, Clonidine, Epinephrine, 0.9% sodium chloride
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Jul 22, 2026, 5:26 PM EDT
Terminated No phase listed Observational

A Prospective Study to Evaluate the ConforMIS iTotal® (PS) Knee Replacement System

NCT03152162
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
iTotal PS KRS
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
4
States / cities
Chapel Hill, North Carolina • Austin, Texas • Morrisville, Vermont + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Jul 22, 2026, 5:26 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis

NCT06105788
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Pain Chronic, Central Pain Syndrome
Interventions
Exercise
Other
Lead sponsor
University of Texas, El Paso
Other
Eligibility
45 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Dec 15, 2024 · Synced Jul 22, 2026, 5:26 PM EDT
Completed No phase listed Observational

Study of Surgical Technique With Use of Single-radius Prosthesis in Total Knee Replacement

NCT01505452
View directory record Official record
Conditions
Arthritis of Knee
Interventions
Not listed
Lead sponsor
Athens Orthopedic Clinic, P.A.
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 8, 2019 · Synced Jul 22, 2026, 5:26 PM EDT
Not yet recruiting Phase 2Phase 3 Interventional

Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.

NCT07151417
View directory record Official record
Conditions
Knee Osteoarthritis, Musculoskeletal Disease, Surgery
Interventions
PAI, PAI + steroid, PAI + zilretta
Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Jul 22, 2026, 5:26 PM EDT
Completed No phase listed Observational

Conjoint Analysis of Treatment Preferences for Osteoarthritis

NCT01003925
View directory record Official record
Conditions
Osteoarthritis
Interventions
Standard of care for osteoarthritis treatment, Conjoint Analysis for Osteoarthritis
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
65 Years to 95 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 23, 2015 · Synced Jul 22, 2026, 5:26 PM EDT
Not listed Not applicable Interventional

Post-op Ketamine Study

NCT03865550
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Isotonic saline, Ketamine Injectable Solution
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
Not listed
Enrollment
75 participants
Timeline
2016 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 6, 2019 · Synced Jul 22, 2026, 5:26 PM EDT
Active, not recruiting Not applicable Interventional

Moving Well for Total Knee Arthroplasty (TKA)

NCT05217420
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Moving Well, Staying Well
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Jul 22, 2026, 5:26 PM EDT