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ClinicalTrials.gov public records Last synced Nov 1, 2026, 4:38 AM EST

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Showing 625–648 of 844 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Mild Cognitive Impairment Clear all
Terminated Phase 2 Interventional Results available

Phase 2 Study of BIIB092 in Participants With Early Alzheimer's Disease

NCT03352557
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
BIIB092, Placebo
Drug
Lead sponsor
Biogen
Industry
Eligibility
50 Years to 80 Years
Enrollment
654 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
52
States / cities
Birmingham, Alabama • Phoenix, Arizona • Sun City, Arizona + 41 more
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Nov 1, 2026, 4:38 AM EST
Completed Phase 4 Interventional Results available

A 28-Week Open Label Extension Study Evaluating Safety and Tolerability of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment

NCT00934375
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Aricept (donepezil hydrochloride), placebo
Drug
Lead sponsor
Eisai Inc.
Industry
Eligibility
45 Years to 90 Years
Enrollment
145 participants
Timeline
2006 – 2007
U.S. locations
49
States / cities
Alabaster, Alabama • Peoria, Arizona • Sun City, Arizona + 43 more
Source: ClinicalTrials.gov public record
Updated Jan 14, 2014 · Synced Nov 1, 2026, 4:38 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Telehealth Advance Care Planning Intervention in Those With Mild Cognitive Impairment or Unrecognized Dementia

NCT04912245
View directory record Official record
Conditions
Advance Care Planning, Telemedicine, Mild Cognitive Impairment, Unrecognized Dementia, Dementia
Interventions
Telehealth visit
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
65 Years and older
Enrollment
152 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
7
States / cities
Bermuda Run, North Carolina • Conover, North Carolina • High Point, North Carolina + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 7, 2023 · Synced Nov 1, 2026, 4:38 AM EST
Recruiting Not applicable Interventional

Early-Stage Partner in Care Living Alone Plus

NCT06962111
View directory record Official record
Conditions
Dementia, Mild Cognitive Impairment (MCI), Alzheimer Disease
Interventions
Psychoeducational skills training intervention
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
60 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Nov 1, 2026, 4:38 AM EST
Withdrawn Phase 2 Interventional

Clinical Trial of AGB101 for Mild Cognitive Impairment

NCT05986721
View directory record Official record
Conditions
Mild Cognitive Impairment, Prodromal Alzheimer's Disease
Interventions
AGB101, Placebo
Drug
Lead sponsor
AgeneBio
Industry
Eligibility
55 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 25, 2025 · Synced Nov 1, 2026, 4:38 AM EST
Completed Not applicable Interventional

Oral Health Intervention Pilot Study for Individuals With Memory Problems

NCT01808235
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Oral Health Intervention
Behavioral
Lead sponsor
Duke University
Other
Eligibility
60 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 30, 2017 · Synced Nov 1, 2026, 4:38 AM EST
Not listed Not applicable Interventional

Robot-assisted Cognitive Training for Lonely Older Adults With Mild Cognitive Impairment (MCI)

NCT04051918
View directory record Official record
Conditions
Cognitive Change, Cognitive Impairment, Mild, Aging
Interventions
Piano Training
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
65 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 2, 2022 · Synced Nov 1, 2026, 4:38 AM EST
Completed Phase 2 Interventional

Tricaprilin In Age-Associated Memory Impairment

NCT00355550
View directory record Official record
Conditions
Age-Associated Memory Impairment
Interventions
Tricaprilin, Placebo
Drug · Other
Lead sponsor
Cerecin
Industry
Eligibility
50 Years to 85 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
6
States / cities
Brooksville, Florida • DeLand, Florida • Naples, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2020 · Synced Nov 1, 2026, 4:38 AM EST
Completed Phase 2 Interventional Results available

Nicotinamide as an Early Alzheimer's Disease Treatment

NCT03061474
View directory record Official record
Conditions
Alzheimer's Disease, Mild Cognitive Impairment
Interventions
Nicotinamide, Placebo Comparator
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
50 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
Irvine, California • Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 17, 2023 · Synced Nov 1, 2026, 4:38 AM EST
Enrolling by invitation No phase listed Observational

Georgia Memory Net Anti-Amyloid Monoclonal Antibody Registry

NCT05999084
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Anti-amyloid Monoclonal Antibodies (mAbs), Standard of Care
Drug · Combination Product
Lead sponsor
Emory University
Other
Eligibility
50 Years to 90 Years
Enrollment
735 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
8
States / cities
Albany, Georgia • Atlanta, Georgia • Augusta, Georgia + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Nov 1, 2026, 4:38 AM EST
Completed Not applicable Interventional Results available

Stimulation to Improve Memory

NCT03875326
View directory record Official record
Conditions
Mild Cognitive Impairment, Dementia of Alzheimer Type
Interventions
1 mA HD-tDCS, 2 mA HD-tDCS, 3 mA HD-tDCS, Sham
Device
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Nov 1, 2026, 4:38 AM EST
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)

NCT01044758
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI)
Interventions
Levetiracetam 62.5mg, Levetiracetam 125mg, Levetiracetam 250mg, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years to 85 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Nov 1, 2026, 4:38 AM EST
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Light and Sleep Fragmentation

NCT06009289
View directory record Official record
Conditions
Sleep, Mild Cognitive Impairment, Mood Disorders
Interventions
Light therapy
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
65 Years to 99 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Aug 25, 2023 · Synced Nov 1, 2026, 4:38 AM EST
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Longitudinal Early-onset Alzheimer's Disease Study Protocol

NCT03507257
View directory record Official record
Conditions
Early Onset Alzheimer Disease, Alzheimer Disease, Mild Cognitive Impairment
Interventions
Flortaucipir, Florbetaben, Fluorodeoxyglucose
Drug
Lead sponsor
Indiana University
Other
Eligibility
40 Years to 64 Years
Enrollment
850 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
18
States / cities
Sun City, Arizona • Los Angeles, California • Palo Alto, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Nov 1, 2026, 4:38 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Neurofeedback to Aid Vets' Memory

NCT04446481
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Neurofeedback
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Nov 1, 2026, 4:38 AM EST
Completed Not applicable Interventional Results available

Study of a Behavioral Intervention for Older Advanced Cancer Patients and Their Caregivers

NCT05200572
View directory record Official record
Conditions
Cancer, Advanced, Cognitive Impairment, Mild
Interventions
Dyadic Life Review (DLR)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Nov 1, 2026, 4:38 AM EST
Completed Phase 2 Interventional

Randomized, Controlled Study Evaluating CERE-110 in Subjects With Mild to Moderate Alzheimer's Disease

NCT00876863
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
CERE-110: Adeno-Associated Virus injection Surgery, Placebo Surgery
Drug · Procedure
Lead sponsor
Sangamo Therapeutics
Industry
Eligibility
55 Years to 80 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
10
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2020 · Synced Nov 1, 2026, 4:38 AM EST
Completed Not applicable Interventional Results available

Smartphone App to Improve Physical Activity in Older Adults With MCI/Mild Dementia

NCT04950998
View directory record Official record
Conditions
Sedentary Lifestyle, Dementia, Mild, Mild Cognitive Impairment, Memory and Thinking Problems
Interventions
Moving Up - A
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
65 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 27, 2023 · Synced Nov 1, 2026, 4:38 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

5-Cog Battery for Detecting Cognitive Impairment and Dementia

NCT03816644
View directory record Official record
Conditions
Dementia, Cognitive Impairment, Mild Cognitive Impairment, Neurocognitive Disorders
Interventions
5-Cog, Health Literacy & Grip Assessment
Other
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
65 Years and older
Enrollment
1,201 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Nov 1, 2026, 4:38 AM EST
Terminated Phase 3 Interventional Results available

A 24-Month Study to Evaluate the Efficacy and Safety of Elenbecestat (E2609) in Participants With Early Alzheimer's Disease

NCT02956486
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
Elenbecestat, Placebo
Drug
Lead sponsor
Eisai Co., Ltd.
Industry
Eligibility
50 Years to 85 Years
Enrollment
2,212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
88
States / cities
Chandler, Arizona • Colton, California • Costa Mesa, California + 68 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Nov 1, 2026, 4:38 AM EST
Completed Phase 2 Interventional

Evaluation of Safety & Tolerability of Multiple Dose Regimens of CHF 5074 and Exploration of Effects on Potential Markers of Clinical Efficacy in Patients With Mild Cognitive Impairment - Open Label Extension (CT04 OLEP)

NCT01421056
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
CHF 5074 1x, CHF 5074 2x, CHF 5074 3x
Drug
Lead sponsor
Chiesi Farmaceutici S.p.A.
Industry
Eligibility
18 Years to 79 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
4
States / cities
Eatontown, New Jersey • Monroe Twp, New Jersey • Toms River, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2014 · Synced Nov 1, 2026, 4:38 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Online Interplay Between Deciding and Acting With Mild Cognitive Impairment

NCT06493422
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Reaching Movements
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
45 Years to 90 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Nov 1, 2026, 4:38 AM EST
Completed Not applicable Interventional Results available

Noninvasive Brain Stimulation for Mild Cognitive Impairment

NCT03331796
View directory record Official record
Conditions
Mild Cognitive Impairment, Mild Neurocognitive Disorder, Cognitive Decline, Mental Deterioration, Cognitive Dysfunction, Memory Decline, Memory Loss, Memory Impairment
Interventions
Active rTMS (Bilateral DLPFC), Active rTMS (Bilateral LPC), Placebo rTMS (Inactive)
Device
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
55 Years to 90 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Nov 1, 2026, 4:38 AM EST
Completed No phase listed Observational

Development of an EEG Diagnostic for Alzheimer's Disease

NCT04954183
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer Disease, Dementia With Lewy Bodies, Normal Control APOE e4 Carriers and Noncarriers
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
50 Years to 85 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Nov 1, 2026, 4:38 AM EST