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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Mitral Valve Incompetence Clear all
Terminated Not applicable Interventional Results available

Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE)

NCT03016975
View directory record Official record
Conditions
Functional Mitral Regurgitation, Mitral Regurgitation, Mitral Insufficiency
Interventions
Edwards Cardioband System, Guideline Directed Medical Therapy
Device · Drug
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
24
States / cities
Los Angeles, California • Palo Alto, California • Aurora, Colorado + 18 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Sep 27, 2026, 1:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of 31P MRS to Assess Brain NAD+ in Healthy Current and Former Collegiate Athletes

NCT02721537
View directory record Official record
Conditions
Concussion, Mild
Interventions
Nicotinamide Riboside, Matching placebo
Dietary Supplement · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
2
States / cities
Minneapolis, Minnesota • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 2, 2022 · Synced Sep 27, 2026, 1:59 AM EDT
Recruiting Not applicable Interventional

An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

NCT04029337
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Transcatheter Mitral Valve Replacement
Device
Lead sponsor
HighLife SAS
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
10
States / cities
Tucson, Arizona • Los Angeles, California • Atlanta, Georgia + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2025 · Synced Sep 27, 2026, 1:59 AM EDT
Completed No phase listed Observational

Cortical Excitability and Inhibition in MDD

NCT01718730
View directory record Official record
Conditions
Major Depressive Disorder, Recurrent, Mild, Depressive Disorder, Major
Interventions
Transcranial Magnetic Stimulation (TMS), Magnetic Resonance Spectroscopy and Imaging
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
13 Years to 21 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 21, 2019 · Synced Sep 27, 2026, 1:59 AM EDT
Terminated No phase listed Observational

Restoring Glutathione Synthesis With Tecfidera: An in Vivo H-MRS Single-Arm Study at 7T in Patients With RR MS

NCT02218879
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Tecfidera
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 4, 2016 · Synced Sep 27, 2026, 1:59 AM EDT
Active, not recruiting Not applicable Interventional

MitraClip REPAIR MR Study

NCT04198870
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
MitraClip™ device implantation, Mitral Valve Repair Surgery
Device · Procedure
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2035
U.S. locations
63
States / cities
Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 47 more
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 27, 2026, 1:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Hippocampal Neurogenesis in Human Subjects

NCT02028273
View directory record Official record
Conditions
Hippocampal Neurogenesis in Cocaine Addiction
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 55 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 8, 2019 · Synced Sep 27, 2026, 1:59 AM EDT
Completed Not applicable Interventional Results available

Safety Study of Repeated Doses of Glucagon on Animal Starch in the Liver

NCT01986231
View directory record Official record
Conditions
Type 1 Diabetes Mellitus
Interventions
Glucagon
Drug
Lead sponsor
Legacy Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 3, 2015 · Synced Sep 27, 2026, 1:59 AM EDT
Active, not recruiting Not applicable Interventional Results available

PARTNER 3 Trial - Mitral Valve in Valve

NCT03193801
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Disease, Mitral Valve Regurgitation, Heart Failure
Interventions
Edwards SAPIEN 3 transcatheter valve, Model 9600TFX
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
Not listed
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2031
U.S. locations
9
States / cities
Atlanta, Georgia • Chicago, Illinois • Evanston, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Sep 27, 2026, 1:59 AM EDT
Recruiting Phase 4 Interventional

International Care Bundle Evaluation in Cerebral Hemorrhage Research

NCT06429332
View directory record Official record
Conditions
Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage, Stroke, Cerebrovascular Disease
Interventions
Reversal of Oral anticoagulation within 30 minutes, Early intensive blood pressure lowering, Treatment of pyrexia, Hyperglycemia treatment, Do-not-resuscitate (DNR) or withdrawal of care, Referral to Intensive Care, Referral to Neurosurgery, Repeat brain imaging, Standard care
Other · Diagnostic Test
Lead sponsor
Region Skane
Other
Eligibility
18 Years and older
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 27, 2026, 1:59 AM EDT
Recruiting No phase listed Observational

Examination of Nociscan Impact on Low Back Pain Surgical Outcomes

NCT06661850
View directory record Official record
Conditions
Low Back Pain
Interventions
Fusion or TDR determined by investigator.
Procedure
Lead sponsor
Aclarion
Industry
Eligibility
18 Years to 70 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
10
States / cities
Phoenix, Arizona • Beverly Hills, California • La Jolla, California + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Sep 27, 2026, 1:59 AM EDT
Completed Phase 2 Interventional

Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery

NCT00082121
View directory record Official record
Conditions
Myocardial Ischemia, Coronary Arteriosclerosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency
Interventions
TP10
Drug
Lead sponsor
Avant Immunotherapeutics
Industry
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
18
States / cities
San Francisco, California • Washington D.C., District of Columbia • Gainesville, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2007 · Synced Sep 27, 2026, 1:59 AM EDT
Recruiting No phase listed Observational

CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

NCT04688190
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Disease, Mitral Annular Calcification
Interventions
Not listed
Lead sponsor
Universitätsklinikum Hamburg-Eppendorf
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
9
States / cities
Tucson, Arizona • Los Angeles, California • Tampa, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 27, 2026, 1:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder

NCT04798274
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
Continuous Theta Burst Stimulation
Device
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
11 Years to 25 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 27, 2026, 1:59 AM EDT
Not listed No phase listed Observational

Outcomes of Patients tReated wIth Mitral Transcatheter Edge-to-edge Repair for Primary Mitral Regurgitation Registry

NCT05332782
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Not listed
Lead sponsor
Universitätsklinikum Hamburg-Eppendorf
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 17, 2022 · Synced Sep 27, 2026, 1:59 AM EDT
Completed Not applicable Interventional

Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study

NCT02375282
View directory record Official record
Conditions
Coronary Artery Disease, Mitral Valve Insufficiency, Aortic Valve Stenosis, Aortic Valve Regurgitation, Mitral Valve Stenosis, Coronary Artery Bypass Graft Triple Vessel
Interventions
Ambulation orderly
Procedure
Lead sponsor
Baystate Medical Center
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 5, 2017 · Synced Sep 27, 2026, 1:59 AM EDT
Not listed No phase listed Observational

MRI as a Predictor of Outcomes in Patients Undergoing Mitral Valve Surgery

NCT03012178
View directory record Official record
Conditions
Mitral Valve Insufficiency
Interventions
Mitral valve surgery
Procedure
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 10, 2018 · Synced Sep 27, 2026, 1:59 AM EDT
Active, not recruiting Not applicable Interventional Results available

Transcatheter Mitral Valve Replacement System (TMVR) Pilot Study and The Early Feasibility Study of the TMVR Transseptal System

NCT02322840
View directory record Official record
Conditions
Mitral Valve Insufficiency
Interventions
Twelve TMVR Implant, Medtronic Intrepid™ Transcatheter Transfemoral Mitral Valve Replacement System
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2028
U.S. locations
21
States / cities
Phoenix, Arizona • Los Angeles, California • Atlanta, Georgia + 12 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Sep 27, 2026, 1:59 AM EDT
Active, not recruiting Not applicable Interventional

Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial

NCT03706833
View directory record Official record
Conditions
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
Interventions
Edwards PASCAL System, Abbott Mitraclip System
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
1,247 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2031
U.S. locations
63
States / cities
Phoenix, Arizona • Tucson, Arizona • La Jolla, California + 50 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 27, 2026, 1:59 AM EDT
Terminated Phase 3 Interventional Results available

Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure

NCT00608140
View directory record Official record
Conditions
Mitral Valve Insufficiency, Heart Failure
Interventions
Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT)
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
8
States / cities
Atlanta, Georgia • Boston, Massachusetts • Minneapolis, Minnesota + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2018 · Synced Sep 27, 2026, 1:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

7T MRS in Parkinson's Disease

NCT01237210
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
45 Years to 75 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 31, 2019 · Synced Sep 27, 2026, 1:59 AM EDT
Completed Phase 2 Interventional Results available

31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Parkinson's Disease

NCT03815916
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Gold Nanocrystals
Drug
Lead sponsor
Clene Nanomedicine
Industry
Eligibility
30 Years to 80 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 27, 2026, 1:59 AM EDT
Not listed Not applicable Interventional

Evaluating Infrasonic Hemodynography

NCT04636892
View directory record Official record
Conditions
Aortic Stenosis, Mitral Regurgitation, Pulmonary Hypertension, Heart Failure, Systolic, Cardiovascular Diseases, Coronary Artery Disease
Interventions
MindMics earbud
Other
Lead sponsor
Scripps Health
Other
Eligibility
Not listed
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Sep 27, 2026, 1:59 AM EDT
Enrolling by invitation No phase listed Observational

GABA and GSH in FRDA

NCT07635030
View directory record Official record
Conditions
Friedreich's Ataxia, FRDA
Interventions
MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy)
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
8 Years to 16 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 27, 2026, 1:59 AM EDT